[1]朱文芳,沈建军,付 涛,等.血清GPDA联合肿瘤标志物对胃癌早期诊断的临床价值[J].现代检验医学杂志,2017,32(04):110-112.[doi:10.3969/j.issn.1671-7414.2017.04.031]
　ZHU Wen-fang,SHEN Jian-jun,FU Tao,et al.Clinical Value of Serum GPDA Associated Tumor Markers for Early Diagnosis of Gastric Cancer[J].Journal of Modern Laboratory Medicine,2017,32(04):110-112.[doi:10.3969/j.issn.1671-7414.2017.04.031]
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血清GPDA联合肿瘤标志物对胃癌早期诊断的临床价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年04期
页码:
110-112
栏目:
论著
出版日期:
2017-07-25

文章信息/Info

Title:
Clinical Value of Serum GPDA Associated Tumor Markers for Early Diagnosis of Gastric Cancer
文章编号:
1671-7414(2017)04-110-03
作者:
朱文芳1; 沈建军2; 付 涛1; 邹爱民1; 张 静1
1.长安医院检验科,西安 710016; 2.第四军医大学唐都医院检验科,西安 710038
Author(s):
ZHU Wen-fang1; SHEN Jian-jun2; FU Tao1; ZOU Ai-min1; ZHANG Jing1
1.Department of Clinical Laboratory,Chang'an Hospital,Xi'an 710016,China; 2.Department of Clinical Laboratory, Tangdu Hospital of the Fourth Military Medical University,Xi'an 710038,China
关键词:
胃癌;  肿瘤标志物;  早期诊断;  联合检测;  血清甘氨酰脯氨酸二肽氨基肽酶
分类号:
R735.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2017.04.031
文献标志码:
A
摘要:
目的 探讨血清甘氨酰脯氨酸二肽氨基肽酶(GPDA)联合癌胚抗原(CEA)、糖类抗原724(CA72-4)、糖类抗原242(CA242)检测在胃癌早期诊断中的临床价值。方法 收集长安医院就诊的胃癌患者、萎缩性胃炎患者及健康体检者各60例,用TBA-120FR生化分析仪检测血清GPDA,化学发光分析仪检测血清中CEA,CA724和CA242的水平,分析单项检测和联合检测的阳性率及敏感度。结果 胃癌组GPDA检测结果显著低于萎缩性胃炎及健康对照组,差异具有统计学意义(F=69.532,P=0.000); 胃癌组CEA,CA724和CA242检测结果高于萎缩性胃炎及健康对照组,差异具有统计学意义(CEA:F=59.926,P=0.001; CA724:F=51.056,P=0.001; CA242:F=72.613,P=0.000)。胃癌组血清GPDA,CEA,CA724和CA242单项检测的阳性率为70%,45%,61.7%和50%,肿瘤标志物CEA,CA724,CA242三项联合检测的阳性率为75%,血清GPDA及肿瘤标志物CEA,CA724和CA242四项联合检测的阳性率为86.7%,高于三项及单项检测的阳性率,差异具有统计学意义(F=49.635,P=0.003)。胃癌组血清GPDA,CEA,CA724和CA242单项检测的敏感度是70.2%,50.2%,67.3%和53.2%,肿瘤标志物CEA,CA724,CA242三项联合检测的敏感度为85.6%,血清GPDA及肿瘤标志物CEA,CA724和CA242四项联合检测的敏感度为90.3%,高于三项及单项检测的敏感度,差异具有统计学意义(F= 52.016,P=0.001)。结论 GPDA联合CEA,CA724,CA242肿瘤标志物检测可提高胃癌早期诊断的阳性率及敏感度,对早期胃癌的临床诊断具有重要的意义和价值。
Abstract:
Objective To investigate the clinical value ofserum glycyl-proline dipeptidyl aminopeptidase(GPDA)combined with carcino- embryonic antigen(CEA),carbohydrate antigen724(CA724),carbohydrate antigen242(CA242)in the early diagnosis of gastric cancer.Methods Collected in Changan hospital in patients with gastric cancer and atrophic gastritis patients and healthy subjects 60 cases,by TBA-120FR biochemical analyzer glycyl-proline dipeptidyl aminopeptidase(GPDA),chemiluminescence analyzer to detect the levels of serum CEA,CA724 and CA242,analysis of single detection andjoint detection and the differences between the positive rate and sensitivity.Results The detection of GPDA in gastric cancer group wassignificantly lower than that in atrophic gastritis group and healthy control group,the difference was statistically significant(F=69.532,P=0.000).The results of CEA,CA724 and CA242 in gastric cancer group were higher than thosein atrophic gastritis group and healthy control group,the difference was statistically significant(CEA:F=59.926,P=0.001; CA724:F=51.056,P=0.001; CA242:F=72.613,P=0.000).Serum GPDA,CEA,CA724 and CA242 single detection positive rate were 70%,45%,61.7% and 50%.Tumor markers CEA,CA724,CA242 positive rate of three joint detection was 75%.Serum GPDA and tumor markersof CEA,the positive rate of CA724 and CA242 combined detection of four was 86.7%.The positive rate of three and higher than that of single detection,the difference was statistically significant(F=49.635,P=0.003).Serum GPDA,CEA,CA724 and CA242 single detection sensitivity was 70.2%,50.2%,67.3% and53.2%.Tumor markers CEA,CA724,CA242 three joint detection sensitivity was 85.6%.Serum GPDA and tumor markers CEA,CA724 and CA242 four joint detection sensitivity was 90.3%.The sensitivity was higher than the three items and the individual tests,and the difference was statistically significant(F=52.016,P=0.001).Conclusion GPDA joint CEA,CA724 and CA242 tumor markers detection can improve the positive rate and sensitivity in early diagnosis of gastric cancer,but it will not reduce the diagnostic specificity,theclinical diagnosis of early gastric cancer has important significance and value.

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备注/Memo

备注/Memo:
作者简介:朱文芳(1976-),女,本科,主管检验师,研究方向:临床生物化学检验,E-mail:qq15728784@sina.com。
更新日期/Last Update: 1900-01-01