[1]张 华a,李小侠a,刘 婧a,等.胸腔积液中CEA,FDP和DD检测对良恶性胸腔积液鉴别的意义[J].现代检验医学杂志,2017,32(06):122-124.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　ZHANG Huaa,LI Xiao-xiaa,LIU Jinga,et al.Diagnosis Value of CEA,FDP and DD in the Pleural Effusion Specimens for Benign and Malignant Pleural Effusion[J].Journal of Modern Laboratory Medicine,2017,32(06):122-124.[doi:10.3969/j.issn.1671-7414.2017.06.001]
点击复制

胸腔积液中CEA,FDP和DD检测对良恶性胸腔积液鉴别的意义()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
122-124
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Diagnosis Value of CEA,FDP and DD in the Pleural Effusion Specimens for Benign and Malignant Pleural Effusion
文章编号:
1671-7414(2017)06-122-03
作者:
张 华a; 李小侠a; 刘 婧a; 胡淑玲a; 孙 杨b; 王 翠a; 张利侠a
陕西省人民医院a.检验科; b.统计室,西安 710068
Author(s):
ZHANG Huaa; LI Xiao-xiaa; LIU Jinga; HU Shu-linga; SUN Yangb; WANG Cuia; ZHANG Li-xiaa
a.Department of Clinical Laboratory; b.Department of Statistics,Shaanxi Provincial People's Hospital,Xi'an 710068,China
关键词:
癌胚抗原;  纤维蛋白原降解产物;  D-二聚体;  胸腔积液;  鉴别诊断
分类号:
R446.19
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 探讨胸腔积液中癌胚抗原(CEA)、纤维蛋白原降解产物(FDP)和D-二聚体(DD)的表达对良恶性胸腔积液鉴别诊断的意义。方法 选取陕西省人民医院收治的良性胸腔积液患者40例为良性组,恶性胸腔积液患者30例为恶性组。采用电化学发光免疫法检测两组胸腔积液中CEA的表达水平,胶乳免疫比浊法检测两组胸腔积液中FDP和DD的表达水平。通过ROC分析比较上述三项指标单独和联合检测对良恶性胸腔积液鉴别诊断的价值。结果 恶性胸腔积液中CEA,FDP和DD水平均高于良性组,差异具有统计学意义(t=2.523～3.889,均P<0.01)。CEA,FDP和DD联合检测恶性胸腔积液的敏感度为76.7%,准确率为82.9%,均高于其中一项或两项联合检测(χ2=1.036～3.324,均P<0.05)。结论 胸腔积液中CEA,FDP和DD联合检测对良恶性胸腔积液的鉴别诊断具有重要意义。
Abstract:
Abstract:Objective To investigate the significance of expressions of carcinoembryonic antigen(CEA), fibrinogen degradation products(FDP)and D-dimer(DD)in the pleural effusion specimens for differential diagnosis between the benign and malignant pleural effusion.Methods 40 patients with benign pleural effusion patients and 30 patients with malignant pleural effusion were divided into benign or malignant group.The levelsof CEA in pleural effusion was detected by electrochemiluminescence,and FDP and DD were measured by turbidimetry.The value of diagnosis of three separate indicators and combine detection was compared by ROC analysis.ResultsThe levels of CEA,FDP and DD in the pleural effusion specimens ofmalignanat group were significantly higher than the benign group(t=2.523～3.889,all P<0.01).The sensitivity of combined detection of CEA,FDP andDD was 76.7%,and the rate of correct diagnosis was 82.9%.The sensitivity anddiagnostic dffeiciency of combined detection were higher than separate indicators(χ2=1.036～3.324,all P<0.05).Conclusion Combined detection of CEA,FDP and DD is helpful to differential diagnosis ofbenign and malignant pleural effusion.

参考文献/References:

[1] 雍文穆,仲 健,田应选,等.多肿瘤标志物检测对良恶性胸腔积液的鉴别诊断[J].白求恩军医学院学报,2010,8(4),267-269. Yong WM,Zhong J,Tian YX,et al.Differential diagnosis of benign and malignant pleural effusion with multiple tumor markers[J].Journal of Bethune Military Medical College,2010,8(4),267-269.
[2] Froudarakis ME.Pleural effusionin lung cancer:more questions than answers[J].Respiration,2012,83(5):367-376.
[3] Thomas JM,Musani AI.Malignant pleural effusions:a review[J].Clin Chest Med,2013,34(3):459-471.
[4] 张毅敏,夏文进,毛彩萍,等.血清标志物CYFRA21-1,NSE,CEA,CA19-9,CA125,SCC联合检测在肺癌诊断中的应用价值[J].中国癌症杂志,2008,18(4):306-309. Zhang YM,Xia WJ,Mao CP,et al.Combined measurement of serum CYFRA21-1,NSE,CEA,CA19-9,CA125 and SCC diagnosis value to lung cancer[J].China Oncology,2008,18(4):306-309.
[5] 李秀娥,王 禺,王双云.D-二聚体与纤维蛋白(原)降解产物在冠心病诊断中的应用价值[J].西部医学,2012,24(9):1794-1796. Li XE,Wang Y,Wang SY.The application value of D-dimer and fiberprotein degradation products in diagnosis of coronary heart disease[J].Medical Journal of West China,2012,24(9):1794-1796.
[6] 应海平.胸水ADA和CEA检测在胸腔积液中的鉴别诊断价值[J].现代实用医学,2006,18(6):390-391. Ying HP.Differential diagnosis of pleural effusion wi-th ADA and CEAin pleural effusion[J].Modern Practical Medicine,2006,18(6):390-391.
[7] 李芳芳,路 尧,张国俊.胸水CA125,CA199,CEA,NSE,CYFRA21-1,CA72-4对原发性肺癌的诊断价值[J].肿瘤基础与临床,2014,27(1):49-52. Li FF,Lu Y,Zhang GJ.Clinical value of detection of CA125,CA199,CEA,NSE,CYFRA21-1 and CA72-4 in pleural effusion in primary lung cancer[J].Journal of Basic and Clinical Oncology,2014,27(1):49-52.
[8] 姜路明.联合检测胸水ADA,CEA,CA125,CA153在结核性与恶性胸水中的鉴别诊断价值[J].中国现代医学杂志,2012,14(6):53-55. Jiang LM.The differential diagnosis value of combined detection ofhydrothorax ADA,CEA,CA125,CA153 in tuberculous and malignant pleural effusion[J].Modern Medicine of Journal Chinese,2012,14(6):53-55.
[9] Ramshanker V,Krishnamurthy A.Lung cancer detection by screening-presenting circulating miRNAs as a promising next generation biomarker breakthrough[J].Asian Pac J Cancer Prev,2013,14(4):2167-2172.
[10] 王 君,梁晓燕,智彩艳,等.联合检测CEA,CA 125,CA199及ADA在胸腔积液病因诊断中的应用价值[J].现代检验医学杂志,2014,29(3):102-105. Wang J,Liang XY,Zhi CY,et al.Value of combined detection of CEA,CA125,CA199 and ADA in the diagnosis of pleural effusion[J].Journal of Modern Laboratory Medicine,2014,29(3):102-105.
[11] 田同德,储真真,陈信义.恶性肿瘤患者血凝异常的研究进展[J].北京中医药大学学报(中医临床版),2009,16(1):38-41. Tian TD,Chu ZZ,Chen XY.Research progress of blood coagulation abnormality in patients with malignant tumor[J].Journal of Beijing University of Chinese Medicine(Chinese Medicine Clinical Edition),2009,16(1):38-41.
[12] 张建辉,李艳艳.联合血浆、胸水D-二聚体及纤维蛋白原检测在肺癌诊治中的临床价值[J].国际检验医学杂志,2013,34(14):1900-1901. Zhang JH,Li YY.Clinical value of combined detection of D-dimer and fibrinogen in plasma and pleural effusion in the diagnosis and treatment of lung cancer[J].International Journal of Laboratory Medicine,2013,34(14):1900-1901.
[13] 张亚男,赵宗兴,张亚坤,等.血清肿瘤标记物在肺癌诊断中的意义[J].中国实验诊断学,2014,18(2):219-222. Zhang YN,Zhao ZX,Zhang YK,et al.Clinical significance of tumor marker in the diagnosis of lung cancer[J].Chinese Journal of Laboratory Diagnosis,2014,18(2):219-222.
[14] 冯纾琪,黄钰君,廖春淼,等.用ROC曲线分析胸腔积液和血清肿瘤标志物联合检测对肺癌的诊断价值[J],现代检验医学杂志,2013,28(1):127-129,132. Feng SQ,Huang YJ,Liao CM,et al.Diagnosis value of the lung cancer through analysis the tumor markers of pleural effusion and serum detection with ROCcurve[J],Journal of Modern Laboratory Medicine,2013,28(1):127-129,132. 收稿日期:2017-07-04 修回日期:2017-10-18

相似文献/References:

[1]何晓璇a,王 刚a,郭 炫a,等.FIB,DD和FDP在高血压肾损伤中的变化及临床意义[J].现代检验医学杂志,2016,31(02):73.[doi:10.3969/j.issn.1671-7414.2016.02.022]
　HE Xiao-xuana,WANG Ganga,GUO Xuana,et al.Changes and Clinical Significance Observation on FIB, DD and FDP in Renal Impairment of Hypertension[J].Journal of Modern Laboratory Medicine,2016,31(06):73.[doi:10.3969/j.issn.1671-7414.2016.02.022]
[2]朱 晶,翟海军.血清CEA,Ferritin和血浆D-D对肺癌化疗的效果评估[J].现代检验医学杂志,2015,30(04):144.[doi:10.3969/j.issn.1671-7414.2015.04.044]
　ZHU Jing,ZHAI Hai-jun.Evaluation on the Effect of Serum CEA,Ferritin and Plasma D-D on Lung Cancer Chemotherapy[J].Journal of Modern Laboratory Medicine,2015,30(06):144.[doi:10.3969/j.issn.1671-7414.2015.04.044]
[3]詹颉,常宁宁,李小侠,等.CEA，AFP，CA125，CA199和CA72-4联合检测在鉴别卵巢良恶性疾病中的应用价值[J].现代检验医学杂志,2015,30(05):50.[doi:10.3969/j.issn.1671-7414.2015.05.015]
　ZHAN Jie,CHANG Ning-ning,LI Xiao-xia,et al.Clinical Value of Combined Detection of CEA，AFP，CA125，CA199 and CA72-4 in the Identification of Ovarian Benign and Malignant Disease[J].Journal of Modern Laboratory Medicine,2015,30(06):50.[doi:10.3969/j.issn.1671-7414.2015.05.015]
[4]王芳胜,熊敦勇,寇辉,等.血清AFP，CEA，CA-199与TAP在肝癌诊断中的应用价值[J].现代检验医学杂志,2015,30(05):148.[doi:10.3969/j.issn.1671-7414.2015.05.047]
　WANG Fang-sheng,XIONG Dun-yong,KOU Hui,et al.Application Value of Serum AFP，CEA，CA-199 and TAP in the Diagnosis of Hepatocellular Carcinoma[J].Journal of Modern Laboratory Medicine,2015,30(06):148.[doi:10.3969/j.issn.1671-7414.2015.05.047]
[5]季红兵,唐芹芳,陈思聪,等.血清肿瘤标志物HE4对肺癌的诊断价值[J].现代检验医学杂志,2017,32(02):110.[doi:10.3969/j.issn.1671-7414.2017.02.030]
　JI Hong-bin,TANG Qin-fang,CHEN Si-cong,et al.Application of Serum HE4 in the Diagnosis of Lung Cancer[J].Journal of Modern Laboratory Medicine,2017,32(06):110.[doi:10.3969/j.issn.1671-7414.2017.02.030]
[6]陈绪阳a,吉茂礼b,刘雪花b,等.外周血MPV,PDW与血清CEA联合检测对胃癌和胃溃疡的鉴别诊断作用[J].现代检验医学杂志,2019,34(01):107.[doi:10.3969/j.issn.1671-7414.2019.01.028]
　CHEN Xu-yanga,JI Mao-lib,LIU Xue-huab,et al.Differential Diagnosis of Gastric Cancer and Gastric Ulcer by Joint Detection of Peripheral Blood MPV，PDW and Serum[J].Journal of Modern Laboratory Medicine,2019,34(06):107.[doi:10.3969/j.issn.1671-7414.2019.01.028]
[7]刘　涛,杨　燕,刘　博,等.联合检测胸腹腔积液sCD44V6,CEA,CYFRA21-1,CA199，NSE,CA125 对良恶性疾病鉴别诊断价值研究[J].现代检验医学杂志,2020,35(02):53.[doi:10.3969/j.issn.1671-7414.2020.02.016]
　LIU Tao,YANG Yan,LIU Bo,et al.Value of Combined Detection of sCD44V6, CEA,CYFRA21-1,CA199,NSEand CA125 in the Differential Diagnosis of Benign and MalignantPleural and Peritoneal Effusion[J].Journal of Modern Laboratory Medicine,2020,35(06):53.[doi:10.3969/j.issn.1671-7414.2020.02.016]

备注/Memo

备注/Memo:
作者简介:张 华(1966-),女,主管检验师,主要研究方向临床检验。 通讯作者:李小侠(1976-),女,主管检验师,主要研究方向临床检验。
更新日期/Last Update: 2017-12-26