[1]吕艳关,王丽,赵玉杰.子痫前期患者血清PCT,HSP9及hs-CRP检测的临床意义[J].现代检验医学杂志,2018,33(04):83-86.[doi:10.3969/j.issn.1671-7414.2018.04.022]
　LV Yan-guan,WANG Li,ZHAO Yu-jie.Clinical Significance of Detecting Serum PTC,HSP90 and hs-CRP in Patients with Pre-Eclamptic L[J].Journal of Modern Laboratory Medicine,2018,33(04):83-86.[doi:10.3969/j.issn.1671-7414.2018.04.022]
点击复制

子痫前期患者血清PCT,HSP9及hs-CRP检测的临床意义()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年04期
页码:
83-86
栏目:
论著
出版日期:
2018-08-30

文章信息/Info

Title:
Clinical Significance of Detecting Serum PTC,HSP90 and hs-CRP in Patients with Pre-Eclamptic L
文章编号:
1671-7414(2018)04-083-04
作者:
吕艳关; 王丽; 赵玉杰
扬州大学附属淮安市妇幼保健院医学检验科,江苏淮安 223002
Author(s):
LV Yan-guan; WANG Li; ZHAO Yu-jie
Department of Laboratory Medicine,Huai'an Women & Children Hospital, Affiliated to Yangzhou University,Jiangsu Huai'an 223002,China
关键词:
子痫前期;  降钙素原;  热休克蛋白90;  超敏C反应蛋白
分类号:
R714.244; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.04.022
文献标志码:
A
摘要:
目的 通过检测子痫前期(preeclampsia,PE)患者血清中降钙素原(procalcitonin,PCT)、热休克蛋白90(heat shock protein,HSP90)和超敏C反应蛋白(highsensitivity C-reactive protein,hs-CRP),评价它们在子痫前期诊断中的临床价值。方法 将65例子痫前期孕妇分为轻度子痫前期组(轻度组)和重度子痫前期组(重度组),另选择同期34例健康孕妇作为对照组。各组受试者均检测血清PCT,HSP90及hs-CRP水平,分析其与子痫前期及其严重程度的相关性。结果 ①轻度组、重度组、对照组血清PCT表达水平分别为0.22±0.05,0.88±0.13和0.04±0.02 ng/ml,各组之间差异具有统计学意义(F=9.73,P<0.01),与对照组相比,重度组(q=7.36,P<0.01)、轻度组(q=5.27,P<0.01),差异均具有统计学意义。②轻度组、重度组、对照组血清HSP90表达水平分别为1.10±0.16,2.7±0.26和0.38±0.15 ng/ml,各组之间差异具有统计学意义(F=8.52,P<0.01),与对照组相比,重度组(q=6.34,P<0.01)、轻度组(q=4.48,P<0.01),差异均具有统计学意义。③轻度组、重度组、对照组血清hs-CRP表达水平分别为17.50±2.90,63.00±12.20和3.90±0.90 mg/L,各组之间差异具有统计学意义(F=11.59,P<0.01),与对照组相比,重度组(q=9.37,P<0.01)、轻度组(q=5.46,P<0.01),差异均具有统计学意义。④子痫前期组血清中PCT,HSP90及hs-CRP表达水平与其疾病严重程度正相关(r值分别为0.871,0.874,0.931,均P<0.01)。结论 血清PCT,HSP90及hs-CRP与子痫前期的发生及疾病严重程度高度相关,可用于子痫前期的预测、诊断及疾病严重程度的评估。
Abstract:
Abstract:Objective To detect PCT, HSP90 and hs-CRP inserum of patients with preeclampsia(PE)to evaluate their clinical value in the diagnosis of pre-eclampsia.Methods 65 pre-eclampsiapregnant women were divided into mild pre-eclampsia group(mild group)and severe pre-eclampsia group(severe group).Another 34 healthy pregnant women were selected as the control group.Serum PCT,HSP90 and hs-CRP levels were measuredin each group,and their correlation with preeclampsia and severity was analyzed.Results ①The PCT expression levels of the mild,severe,and control groups were 0.22±0.05,0.88±0.13 and 0.04±0.02 ng/ml,respectively.The difference between the groups was statistically significant(F=9.73,P<0.01),compared with the control group,the severe group(q=7.36,P<0.01)and the mild group(q=5.27,P<0.01),and the difference was statistically significant.②The levels of serum HSP90 in the mild,severe and control groups were 1.10±0.16,2.7±0.26 and 0.38±0.15 ng/ml,respectively.The difference between the groups was statistically significant(F=8.52,P<0.01)compared with the control group,the severe group(q=6.34,P<0.01)and the mild group(q=4.48,P<0.01),and the difference was statistically significant.③The serum hs-CRP expression levels in the mild group,the severe group and the control group were 17.50±2.90,63.00±12.20 and 3.90±0.90 mg/L,respectively.The difference between the groups was statistically significant(F=11.59,P<0.01)compared with the control group,the severe group(q=9.37,P<0.01)and the mild group(q=5.46,P<0.01),and the difference was statistically significant.④The expression of PCT,HSP90 and hs-CRP in the serum of preeclampsia group was positively correlated with the severityof the disease(r=0.871,0.874,0.931,P<0.01)respectively.Conclusion Serum PCT,HSP90 and hs-CRP are highly correlatedwith the incidence of preeclampsia and disease severity,and they can be used for the prediction,diagnosis and severity assessment of preeclampsia.

参考文献/References:

[1] Sircar M,Thadhani R,Karumanchi SA.Pathogenesis of preeclampsia[J].Curr Opin Nephrol Hypertens,2015,24(2):131-138.
[2] 周忠义,施 蕾,谢晓红.子痫前期孕妇血清胆碱酯酶、炎症因子的变化及意义[J].中国妇幼保健,2015,30(23):3946-3949. Zhou ZY,Shi L,Xie XH.Changes and significance of serum cholinesterase and inflammatory cytokines in pregnant women with preeclampsia[J].Maternal & Child Health Care of China,2015,30(23):3946-3949.
[3] 乐 杰.妇产科学[M].7版.北京:人民卫生出版社,2009:92-105. Le J.Obstetrics and gynecology[M].7th Ed.Beijing:People's Health Press,2009:92-105.
[4] Phipps E,Prasanna D,Brima W,et al.Preeclampsia:Updates in Pathogenesis,Definitions and Guidelines[J].Clin J Am Soc Nephrol,2016,11(6):1102-1113.
[5] Sánchez-Aranguren LC,Prada CE,Ria(¨overn)o-Medina CE,et al.Endothelial dysfunction and preeclampsia:role of oxidative stress[J].Front Physiol,2014,5:372.
[6] Harmon AC,Cornelius DC,Amaral LM,et al.The role of inflammation in the pathology of preeclampsia[J].Clin Sci(Lond),2016,130(6):409-419.
[7] Bunchorntavakul C,Chamroonkul N,Chavalitdhamrong D.Bacterial infections in cirrhosis: A critical review and practical guidance[J].World J Hepatol,2016,8(6):307-321.
[8] Artunc-Ulkumen B,Guvenc Y,Goker A,et al.Relationship of neutrophil gelatinase-associated lipocalin(NGAL)and procalcitonin levels with the presence and severity of the preeclampsia[J].J Matern Fetal Neonatal Med,2015,28(16):1895-1900.
[9] Yin Y,Feng Y,Zhao H,et al.SIRT1 inhibits releases of HMGB1 and HSP70from human umbilical vein-endothelial cells caused by IL-6 and the serum froma preeclampsia patient and protects the cells from death[J].Biomed Pharmacother,2017,88:449-458.
[10] Thilaganathan B,Wormald B,Zanardini C,et al.Early-pregnancymultiple serum markers and second-trimester uterine artery doppler in predicting preeclampsia[J].Obstet Gyneol,2010,115(6):1233-1238.
[11] Gammill HS,Powers RW,Clifton RG,et al.Dose C-reactive protein predict recurrent preeclampsia[J].Hypertens Pregnancy,2010,29(4):399-409.
[12] 高洪娟,王永红.子痫前期发病机制的研究进展[J].国际妇产科学杂志,2015,42(6):685-688. Gao HJ,Wang YH.Progress on the pathogenesis of pre-eclampsia[J].J Int Obstet Gynecol,2015,42(6):685-688.

相似文献/References:

[1]王苏梦,唐海霞,印中鹏,等.血浆抗凝血酶Ⅲ和血清降钙素原检测在腹腔感染诊断和预后中的临床价值[J].现代检验医学杂志,2016,31(02):22.[doi:10.3969/j.issn.1671-7414.2016.02.007]
　WANG Su-meng,TANG Hai-xia,YIN Zhong-peng,et al.Value of Detecting ATⅢ and Serum PCT Levels in Diagnosis and Prognosis of Abdominal Infection[J].Journal of Modern Laboratory Medicine,2016,31(04):22.[doi:10.3969/j.issn.1671-7414.2016.02.007]
[2]罗 强,刘振杰,徐 宁,等.联合检测SAA,hs-CRP,PCT和WBC在广东地区不同年龄人群感染患者诊断价值的多中心分析[J].现代检验医学杂志,2015,30(04):39.[doi:10.3969/j.issn.1671-7414.2015.04.010]
　LUO Qiang,LIU Zhen-jie,XU Ning,et al.Multicenter Study on Serum Amyloid A Protein, High-Sensitivity C-Reactive Protein and Procalcitonin in Combining Diagnosis of Infection in Different Population from Guangdong[J].Journal of Modern Laboratory Medicine,2015,30(04):39.[doi:10.3969/j.issn.1671-7414.2015.04.010]
[3]仇秋明,赵英伦.子痫前期患者血清中TFAR19活性研究[J].现代检验医学杂志,2015,30(02):68.[doi:10.3969/j.issn.1671-7414.2015.02.021]
　QIU Qiu-ming,ZHAO Ying-lun.Serum TFAR19 Activity in Preeclampsia Patients[J].Journal of Modern Laboratory Medicine,2015,30(04):68.[doi:10.3969/j.issn.1671-7414.2015.02.021]
[4]郭进京.孕中期母血PAPPA与PIGF在预测子痫前期发生的作用[J].现代检验医学杂志,2016,31(05):115.[doi:10.3969/j.issn.1671-7414.2016.05.032]
　GUO Jin-jing.Role of Maternal PAPPA and PIGF Levels at Second Trimester in the Prediction of Preeclampsia[J].Journal of Modern Laboratory Medicine,2016,31(04):115.[doi:10.3969/j.issn.1671-7414.2016.05.032]
[5]王秀珍,李连友,王秀梅.子痫前期患者血清中PDGF-BB和U-Ⅱ检测的临床价值[J].现代检验医学杂志,2016,31(06):82.[doi:10.3969/j.issn.1671-7414.2016.06.023]
　WANG Xiu-zhen,LI Lian-you,WANG Xiu-mei.Clinical Value of Serum PDGF-BB and U-Ⅱ in Patients with Preeclampsia[J].Journal of Modern Laboratory Medicine,2016,31(04):82.[doi:10.3969/j.issn.1671-7414.2016.06.023]
[6]甘 露a,刘西玲b,王 婷c,等.子痫前期患者血清及尿液中miR-125a/b-5p的表达及相关临床研究[J].现代检验医学杂志,2017,32(06):32.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　GAN Lua,LIU Xi-lingb,WANG Tingc,et al.Expression of miR-125a/b-5p in Serum and Urine of Preeclampsia and Related Clinical Studies[J].Journal of Modern Laboratory Medicine,2017,32(04):32.[doi:10.3969/j.issn.1671-7414.2017.06.001]
[7]颜宇飞a,陈 燕,李灵筠a,等.外周血NEUT-X参数、超敏CRP及降钙素原检测在儿童上呼吸道细菌感染诊断中的价值探讨[J].现代检验医学杂志,2018,33(03):123.[doi:10.3969/j.issn.1671-7414.2018.03.031]
　YAN Yu-feia,CHEN Yan,LI Ling-juna,et al.Clinical Value of Peripheral Blood NEUT-X Parameters, Hypersensitive CRP and PCT in the Diagnosis of Bacterial Upper Respiratory Tract Infection in Children[J].Journal of Modern Laboratory Medicine,2018,33(04):123.[doi:10.3969/j.issn.1671-7414.2018.03.031]
[8]王结珍,梁培松,王伟佳,等.血清PCT,IL-6和CRP水平检测对白血病患者化疗并发败血症的诊断价值[J].现代检验医学杂志,2019,34(02):88.[doi:10.3969/j.issn.1671-7414.2019.02.023]
　WANG Jie-zhen,LIANG Pei-song,WANG Wei-jia,et al.Diagnostic Value of Serum PCT,IL-6 and CRPin Septicemia Patients with Leukemia in Chemotherapy[J].Journal of Modern Laboratory Medicine,2019,34(04):88.[doi:10.3969/j.issn.1671-7414.2019.02.023]
[9]李志强,吴正霞,张和平,等.老年社区获得性肺炎不同人群血清PCT水平表达的差异性研究[J].现代检验医学杂志,2019,34(03):74.[doi:10.3969/j.issn.1671-7414.2019.03.018]
　LI Zhi-qiang,WU Zheng-xia,ZHANG He-ping,et al.Analysis on the Difference of Serum PCT Expressionin Elderly Patients with Community-Acquired Pneumonia[J].Journal of Modern Laboratory Medicine,2019,34(04):74.[doi:10.3969/j.issn.1671-7414.2019.03.018]
[10]朱 超,安小红.血清PCT和Presepsin水平检测在脊柱疾病术后早期感染中的应用价值[J].现代检验医学杂志,2019,34(03):91.[doi:10.3969/j.issn.1671-7414.2019.03.022]
　ZHU Chao,AN Xiao-hong.Application Value of Serum PCT and Resepsinin Early Infection after Spinal Surgery[J].Journal of Modern Laboratory Medicine,2019,34(04):91.[doi:10.3969/j.issn.1671-7414.2019.03.022]

备注/Memo

备注/Memo:
作者简介:吕艳关(1981-),硕士,副主任技师,主要研究方向:临床免疫学诊断,E-mail:lvyanguan@163.com。 通讯作者:赵玉杰(1988-),女,检验师,硕士,E-mail:5919377@qq.com。
更新日期/Last Update: 2018-08-16