[1]王结珍,梁培松,王伟佳,等.血清PCT,IL-6和CRP水平检测对白血病患者化疗并发败血症的诊断价值[J].现代检验医学杂志,2019,34(02):88-90.[doi:10.3969/j.issn.1671-7414.2019.02.023]
 WANG Jie-zhen,LIANG Pei-song,WANG Wei-jia,et al.Diagnostic Value of Serum PCT,IL-6 and CRPin Septicemia Patients with Leukemia in Chemotherapy[J].Journal of Modern Laboratory Medicine,2019,34(02):88-90.[doi:10.3969/j.issn.1671-7414.2019.02.023]
点击复制

血清PCT,IL-6和CRP水平检测对白血病患者化疗并发败血症的诊断价值()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
88-90
栏目:
论著
出版日期:
2019-05-11

文章信息/Info

Title:
Diagnostic Value of Serum PCT,IL-6 and CRPin Septicemia Patients with Leukemia in Chemotherapy
文章编号:
1671-7414(2019)02-088-03
作者:
王结珍梁培松王伟佳梁艮英
(中山大学附属中山市人民医院检验医学中心,广东中山 528403)
Author(s):
WANG Jie-zhenLIANG Pei-songWANG Wei-jiaLIANG Gen-ying
(Department of Clinical Laboratory,the People's Hospital of Zhongshan City,Affiliated to Sun Yat-sen University,Guangdong Zhongshan 528403,China)
关键词:
白血病 败血症 降钙素原 白介素6 C反应蛋白
分类号:
R557; R446.112
DOI:
10.3969/j.issn.1671-7414.2019.02.023
文献标志码:
A
摘要:
目的 探讨血清PCT,IL-6与CRP水平检测对白血病患者化疗并发败血症的诊断价值。方法 选取2013年1月~2018年7月进行白血病化疗患者252例,包括感染期组和恢复期组(152例),未感染组(100例); 检测各组患者血清PCT,IL-6与CRP水平,并比较组间的差异; 分析三项指标间及其与白血病患者化疗并发败血症的相关性; 分析三项指标及其联合检测在诊断白血病患者化疗并发败血症的价值。结果 感染期组PCT,IL-6与CRP水平均高于恢复期组及未感染组,差异有统计学意义(t=6.11915.078,P=0.000); 三项指标互为相关(r=0.2980.503,P=0.00),并均与白血病化疗并发败血症有显著相关性(wald=4.010~21.989,P=0.000~0.045); PCT+CRP联合检测与PCT+IL-6+CRP联合检测的最高AUC分别为0.970和0.972,两曲线经Z检验差异无统计学意义(z=0.157,P=0.875)。结论 PCT,CRP和IL-6三项指标在白血病患者化疗并发败血症的诊断中有良好的应用价值。
Abstract:
Objective To explore the diagnostic value of serum PCT,IL-6 and CRP in septicemia patients with leukemia in chemotherapy.Methods 252 cases of patients with leukemia in chemotherapy were selected from January 2013 to July 2018,which were divided into infection group,recovery group and uninfected group.The serum PCT,IL-6 and CRP levels of each group were detected,and the differences of each groups were compared.The correlation among the three indicators and the correlation between each indicatorsand septicemia with Leukemia in chemotherapy were analyzed.The diagnosis valueof each indicators and their combination in septicemia patients with leukemia in chemotherapy were analyzed by regression analysis and the ROC curve.Results The levels of PCT,IL-6 and CRP in infection group were higher than in recovery group and uninfected group,and the difference was statistically significant(t=6.119~15.07,all P=0.000).Three indicators were related with each other(r=0.298~0.503,all P=0.000),which all were significantly correlated with septicemia with Leukemia in chemotherapy(wald=4.010~21.989,P=0.000~0.045).The combination of PCT+CRP andPCT+IL-6+CRP had highest AUC:0.970 and 0.972,but the two curves were no statistically significant difference by Z test(z=0.157,P=0.875).Conclusion PCT,CRP and IL-6 indicators have a good diagnostic value in Septicemia patients with leukemia in chemotherapy.

参考文献/References:

[1] 陈红英,杨洪,刘文君.265例儿童急性白血病临床特征分析[J].中国小儿血液与肿瘤杂志,2017,22(6):313-316. CHEN Hongying,YANG Hong,LIU Wenjun.Analysis on clinical features of 265 children with acute leukemia[J].J China Pediatr Blood Cancer,2017,22(6):313-316.
[2] 赵彩芳,魏斌,骆超,等.PCT,Activin-A等生物学指标在急性白血病患者化疗粒细胞缺乏期感染中的诊断价值[J].中华医院感染学杂志,2017,27(3):539-542. ZHAO Caifang,WEI Bin,LUO Chao,et al.Diagnostic value of PCT,activin-A and other biological indicators in the patients with acute leukemiaduring granulocyte deficiency phase after chemotherapy[J].Chin J Nosocomiol,2017,27(3):539-542.
[3] 宋春鸽,马若巾,杨晓煜,等.血清超敏C-反应蛋白与降钙素原及内毒素对白血病患者化疗后感染的诊断价值研究[J].中华医院感染学杂志,2017,27(21):4898-4901. SONG Chunge,MA Ruojin,YANG Xiaoyu,et al.Value of serm high-sensitivity C-reactive protein,procalcitonin and endotoxin in diagnosis of infections in leukemia patients after chemotherapy[J].Chin J Nosocomiol, 2017,27(21):4898-4901.
[4] 张之南,沈梯.血液病的诊断及疗效标准[M].3版.北京:科学出版社,2007:19-65. ZHANG Zhinan,SHEN Ti.Blood disease diagnosis and curative effect of standard[M].3th Ed.Beijing:science press,2007:19-65.
[5] YANG Aiping,LIU Jun,YUE Leihe,et al.Neutro-phil CD64 combined with PCT,CRP and WBC improves the sensitivity for the early diagnosis of neonatal sepsis[J],Clin Chem Lab Med,2016,54(2):345-351.
[6] KIP M M,KUSTERS R,IJZERMAN M J,et al.A P-CT algorithm for discontinuation of antibiotic therapy is a cost-effective way to reduce antibiotic exposure in adult intensive care patients with sepsis[J].J Med Econ,2015,18(11):944-953.
[7] 陶慧娴.降钙素原、超敏C反应蛋白联合白介素6动态检测在新生儿感染早期诊断中的价值[J].中外医疗,2018,37(1):34-36,42. TAO Huixian.The value of procalcitonin,high sensitivity C-reactive protein combined with interleukin-6 in the early diagnosis of neonatal infection[J].China Foreign Medical Treatment,2018,37(1):34-36,42.
[8] 刘同波,王茂全,关伟,等.降钙素原、C反应蛋白和白细胞介素-6在血液病患者血流细菌感染中的诊断意义[J].中国实验血液学杂志,2018,26(5):1548-1552. LIU Tongbo,WANG Maoquan,GUAN wei,et al.Diagnostic values of procalcitonin,C-reactive protein and interleukin-6 in hematological diseases with bacterial infection[J].Journal of Experimental Hematology,2018,26(5):1548-1552.
[9] 施灵敏,徐智胜.CD64、血清降钙素原及C-反应蛋白在儿童急性淋巴细胞白血病化疗后合并细菌感染早期诊断中的意义[J].中国卫生检验杂志,2018,28(4):467-469. SHI Lingmin,XUN Zhisheng.Detection significance of CD64,serum procalcitonin and C-reactive protein in the early diagnosis of bacterial infection after childhood acute lymphocytic leukemia chemotherapy[J].Chin J Health Lab Tec,2018,28(4):467-469.
[10] MATHA S M,RAHIMAN S N,GELBART B G,et al.The utility of procalcitonin in the prediction of serious bacterial infection in a tertiary paediatic intensive care unit[J].Anaesth Intensive Care,2016,44(5):607-614.

相似文献/References:

[1]苗玉迪a,魏绪仓b.达沙替尼联合氟达拉滨对慢粒K562细胞的抑制作用研究[J].现代检验医学杂志,2015,30(05):70.[doi:10.3969/j.issn.1671-7414.2015.05.021]
 MIAO Yu-dia,WEI Xu-cangb.Study on Inhibition of Dasatinib and Fludarabine to CML K562 Cells[J].Journal of Modern Laboratory Medicine,2015,30(02):70.[doi:10.3969/j.issn.1671-7414.2015.05.021]
[2]姚亚洲,郑引索.72例老年急性白血病免疫表型分析[J].现代检验医学杂志,2015,30(05):91.[doi:10.3969/j.issn.1671-7414.2015.05.027]
 YAO Ya-zhou,ZHENG Yin-suo.Immunophenotype Analysis of 72 Cases of Elderly Acute Leukemia[J].Journal of Modern Laboratory Medicine,2015,30(02):91.[doi:10.3969/j.issn.1671-7414.2015.05.027]
[3]付朝泓,李艳,童永清,等.BCR-ABL融合基因核酸检测试剂的研发及临床应用[J].现代检验医学杂志,2015,30(06):52.[doi:10.3969/j.issn.1671-7414.2015.06.015]
 FU Chao-hong,LI Yan,TONG Yong-qing,et al.Development and Clinical Application of A Novel Nucleic Acid Detection Reagent for BCR-ABL Fusion Gene[J].Journal of Modern Laboratory Medicine,2015,30(02):52.[doi:10.3969/j.issn.1671-7414.2015.06.015]
[4]孟凡萍,郝 坡.渝东北地区441 例白血病患者融合基因表达特点分析[J].现代检验医学杂志,2020,35(02):15.[doi:10.3969/j.issn.1671-7414.2020.02.005]
 MENG Fan-ping,HAO Po.Analysis of Expression Characteristics of Fusion Gene in 441 Patientswith Leukemia in Northeastern Chongqing[J].Journal of Modern Laboratory Medicine,2020,35(02):15.[doi:10.3969/j.issn.1671-7414.2020.02.005]

备注/Memo

备注/Memo:
基金项目:2018年中山市卫生局科研立项(2018A020193)。 作者简介:王结珍(1985-),女,本科,主管技师,从事临床检验,E-mail:wanglei8511@163.com。 通讯作者:王伟佳,男,主任技师,博士后,硕士研究生导师,E-mail:xuelangchichao@163.com。 收稿日期:2018-11-17 修回日期:2018-12-24
更新日期/Last Update: 2019-04-30