[1]刘海颖,孟爱国,曾小芳,等.脑梗死和短暂性脑缺血患者外周血RDW与NLR变化及相关性研究[J].现代检验医学杂志,2019,34(02):83-87.[doi:10.3969/j.issn.1671-7414.2019.02.022]
　LIU Hai-ying,MENG Ai-guo,ZENG Xiao-fang,et al.Analysis of Relationship between RDW and Inflammation Indexin Patients with Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2019,34(02):83-87.[doi:10.3969/j.issn.1671-7414.2019.02.022]
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脑梗死和短暂性脑缺血患者外周血RDW与NLR变化及相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
83-87
栏目:
论著
出版日期:
2019-05-11

文章信息/Info

Title:
Analysis of Relationship between RDW and Inflammation Indexin Patients with Cerebral Infarction
文章编号:
1671-7414(2019)02-083-05
作者:
刘海颖1; 孟爱国1; 曾小芳2; 李 宁1; 石 峻1; 赵俊暕1
(1.华北理工大学附属医院检验科,唐山市医学分子检验与诊断重点实验室,河北唐山 063000; 2.唐山市丰润区第二人民医院,河北唐山 063000)
Author(s):
LIU Hai-ying1; MENG Ai-guo1; ZENG Xiao-fang2; LI Ning1; SHI Jun1; ZHAO Jun-jian1
(1.North China University of Science and Technology Affiliated Hospital,Key Laboratory of Medical Molecular Testing and Diagnosis in Tangshan,Hebei Tangshan 063000,China; 2.Department of Clinical Laboratory,the Second Hospital of Fengrun District in Tangs
关键词:
红细胞分布宽度;  中性粒细胞与淋巴细胞比值;  急性脑梗死;  短暂性脑缺血发作
分类号:
R743; R446.11
DOI:
10.3969/j.issn.1671-7414.2019.02.022
文献标志码:
A
摘要:
目的 探讨脑梗死和短暂性脑缺血发作患者外周血红细胞分布宽度(RDW)、中性粒细胞与淋巴细胞比值(NLR)的变化及之间的相关性。方法选取华北理工大学附属医院神经内科2010年5月～2016年7月收治的630例首发的急性脑梗死患者作为脑梗死组,162例首发的短暂性脑缺血发作患者作为短暂性脑缺血发作组,即TIA组,另选取150例健康体检者为对照组,比较各组患者外周血RDW,NLR,白细胞计数,血液流变学相关指标的水平,分析各组患者RDW 与NLR之间的相关性。结果 ①急性脑梗死组水平高于TIA组及对照组[刚性指数4.18±0.49 vs 3.89±0.51和3.74±0.40,红细胞聚集指数4.91±0.59 vs 4.69±0.61和4.12±0.54,NLR 2.38±1.19 vs 2.01±1.00和1.36±0.85,白细胞计数(7.23±1.06 vs 6.42±0.79和5.12±0.82)×109/L,RDW 13.44%±0.59% vs 12.73%±0.58%和11.64%±0.51%],变形指数低于TIA组及对照组[0.66±0.05 vs 0.73±0.05和0.77±0.06],差异均有统计学意义(F=8.952～129.849,49.258,均P<0.001); ②TIA组RDW,红细胞聚集指数,白细胞计数及NLR水平均高于对照组,差异均有统计学意义(P<0.001); ③脑梗死组和TIA组中RDW与NLR呈正相关(r=0.73,P<0.01; r=0.63,P<0.01),但对照组RDW与NLR不相关(r=0.21,P=0.149)。结论 脑梗死和短暂性脑缺血发作患者外周血RDW与NLR呈正相关,RDW可以为脑梗死和短暂性脑缺血发作患者的炎症状态起到提示作用。
Abstract:
Objective To investigate the relationship amongred blood cell distribution width(RDW),peripheral leukocyte count and neutrophil/lymphocyte ratio(NLR)in patients with cerebral infarction and transient ischemic attack,especially the correlation between RDW and NLR,and analyze whether RDW can play a role in indicating the inflammation of cerebral infarction.Methods 630 patients with first-episode acute cerebral infarction were selected as the cerebral infarction group,162 patients with first-episode transient ischemic attack as the transient ischemic attack group(TIAgroup)and 150 healthy persons as the control group.Peripheral blood RDW,NLR,white blood cell count and water of Hemorheology related indicators in each group were compared.Meanwhile,the correlation between RDW and NLR in each group was analyzed.Results ①The level of RBC rigidity index(4.18±0.49 vs 3.89±0.51,3.74±0.40),RBC aggregation index(4.91±0.59vs 4.69±0.61,4.12±0.54),NLR(2.38±1.19 vs 2.01±1.00,1.36±0.85),WBC(7.23±1.06 vs 6.42±0.79,5.12±0.82)×109/L and RDW(13.44%±0.59% vs 12.73%±0.58%,11.64%±0.51%)in acute cerebral infarction group were higher than that of TIA group,and control group and the deformation deformability index(0.66±0.05 vs 0.73±0.05,0.77±0.06)were lower than TIA group and control group(F=8.952～129.849,49.258,P<0.001).②The level of RDW RBC aggregation index,WBC and NLR in the TIA group were higher than control group.There was a significant difference in the control group(P<0.001).③RDW was positively correlated with NLR in cerebral infarction group and TIA group(r=0.73,P<0.01; r=0.63,P<0.01),but RDW was not correlated with NLR in control group(r=0.21,P=0.149).Conclusion The correlation between the RDW and NLR was positive in patients with the cerebral infarction or the TIA,which meant RDW can be a warning for the inflammation of cerebral infarction and the TIA.

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备注/Memo

备注/Memo:
基金项目:河北省医学适用技术跟踪项目(G2018066); 河北省医学科学研究重点课题(20180771)。 作者简介:刘海颖(1992-),女,硕士研究生,检验师,主要研究方向:临床血液学与生物化学检验,E-mail:1452454587@qq.com。 通讯作者:赵俊暕,男,医学硕士,副主任技师,主要研究方向:临床血液学检验,E-mail:meiyitangshan@163.com。 收稿日期:2018-12-23 修回日期:2019-01-03
更新日期/Last Update: 2019-04-30