[1]刘玉嫦,李小玲,黄艳琼.儿童手足口病外周血红细胞分布宽度与疾病严重程度的相关性研究[J].现代检验医学杂志,2019,34(01):85-88.[doi:10.3969/j.issn.1671-7414.2019.01.022]
　LIU Yu-chang,LI Xiao-ling,HUANG Yan-qiong.Correlation between the Distribution Width of Peripheral Blood Red Blood Cells and the Severity of Disease in Children with HFMD[J].Journal of Modern Laboratory Medicine,2019,34(01):85-88.[doi:10.3969/j.issn.1671-7414.2019.01.022]
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儿童手足口病外周血红细胞分布宽度与疾病严重程度的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年01期
页码:
85-88
栏目:
论著
出版日期:
2019-02-28

文章信息/Info

Title:
Correlation between the Distribution Width of Peripheral Blood Red Blood Cells and the Severity of Disease in Children with HFMD
文章编号:
1671-7414(2019)01-085-04
作者:
刘玉嫦; 李小玲; 黄艳琼
(台山市人民医院儿科，广东 江门529200)
Author(s):
LIU Yu-chang; LI Xiao-ling; HUANG Yan-qiong
(Department of Pediatric，Taishan People’s Hospital，Guangdong J iangmen 529200，China)
关键词:
儿童; 手足口病; 红细胞分布宽度
分类号:
R725.1；R446.11
DOI:
10.3969/j.issn.1671-7414.2019.01.022
文献标志码:
A
摘要:
目的探讨外周血红细胞分布宽度(red blood cell distri bution width，RDW)在儿童手足口病(hand-foot-mouth disease，HFMD)中与疾病严重程 度的相关性。方法选择台山市人民医院2015年1月1日～2018年3月3 1日住院的手足口病儿童374例，其中手足口病普通病例336例，手足口病重症病例38例，检 测手足口病普通病例与重症病例RDW并分析其与病情严重程度的相关性。结果 ①手足口病重症组的小儿危重病例评分(PCIS)小于普通组(75.9±6.4 vs 83. 9±5.6， P <0.001)，重症病例组的RDW高于普通组［(15.7±1.5 )% vs (14.3±1 .3)%， P <0.001］，重症病例组的CRP高于普通组［(26.6±9.4)mg/L vs (16.4±3 .8)mg/L， P <0.001］，重症组的血糖高于普通组［(9.6±2.9 )mmol/L vs (7.8 ±2.0)mmol/L， P <0.001］，差异均有统计学意义。②相关性分析显示，RDW与PCIS评 分呈负相关( r=-0.33，P <0.001)，RDW与超敏C反应蛋白呈正相关关系( r=0.139，P =0.007)。③RDW识别重症病例的ROC曲线下面积为0.763，其95%的置信区间为［0.689 ，0.838］，最佳截断值是14.1%，此时灵敏度为0.947，特异度为0.482；血糖的ROC曲 线下面积为0.700，其95%的置信区间为［0.601，0.798］，最佳截断值是9.25　mmol/L ，此时灵敏度为0.605，特异度为0.789。结论RDW与儿童手足口 病的严重程度密切相关，随病情严重程度的加重而升高，有助于儿童手足口病的严重程度评 估，为临床上识别手足口病重症病例提供了一个新的廉价且便捷的指标。
Abstract:
Objective To explore the correlation between th e distribution width of peripheral blood red blood cells and the severity of dis ease in children with Hand-foot-mouth disease (HFMD)．Methods From the first of January 2015 to the thirtyfirst of March 2018，374 case s of children with HFMD who were hospitalized in Taishan People’s Hospital were collected and assigned as 2 groups．The patients were divided into ordinary gro up(n=336) and severe group ( n =38)．Recording various observing data and doin g statistical analysis．Results ①Compared with ordinary group，PCIS，RDW，CRP and blood glucose levels in serve group with statistical significance ［the periods of illness (d)：PCIS：75.9±6.4 vs 83.9±5.6；RD W(%)：(15.7±1.5) vs (14.3±1.3)；CRP：(26.6±9.4)mg/L vs (16.4±3.8)mg/ L；blood glucose levels：(9.6±2.9)mmol/L vs (7.8±2.0)mmol/L，all P <0. 001］．②The correlation analysis between RDW and PCIS showed that RDW was signi ficantly negatively correlated with PCIS ( r=-0.33，P =0.000)，and postively related with CRP ( r=0.139，P =0.007)．③ROC curve analysis showed that RDW could be used to prediction for severe case of HDMF，the area under the ROC cur ve (AUC) was 0.763．When threshold value of RDW was 14.1%，the sensitivity was 94.7%，and the specificity was 48.2%．Conclusion RDW i s a useful marker for evaluate the condition of HFMD．That suggests that RDW can be used as a cheap and convenient index for identifying severe cases of HFMD．

参考文献/References:


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备注/Memo

备注/Memo:

作者简介：刘玉嫦(1984-)，女，儿科学硕士学位，主治医师，研 究方向，儿科感染性疾病，E-mail：3478679122@qq.com。
更新日期/Last Update: 2019-02-28