[1]吉翔,华芸,张学军.哮喘患儿血清白介素与免疫球蛋白检测的临床意义[J].现代检验医学杂志,2015,30(06):127-129.[doi:10.3969/j.issn.1671-7414.2015.06.039]
　JI Xiang,HUA Yun,ZHANG Xue-jun.Clinical Significance of Combined Detection of Serum Interleukin and Immune Globulin in Children with Asthma[J].Journal of Modern Laboratory Medicine,2015,30(06):127-129.[doi:10.3969/j.issn.1671-7414.2015.06.039]
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哮喘患儿血清白介素与免疫球蛋白检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年06期
页码:
127-129
栏目:
检验与临床
出版日期:
2015-12-30

文章信息/Info

Title:
Clinical Significance of Combined Detection of Serum Interleukin and Immune Globulin in Children with Asthma
作者:
吉翔1; 华芸2; 张学军3
1．扬州市第二人民医院(惠民医院)检验科，江苏扬州225007； 2．苏北人民医院儿科，江苏苏北225001；3．扬州市第一人民医院检验科，江苏扬州225001
Author(s):
JI Xiang1; HUA Yun2; ZHANG Xue-jun3
1.Department of Clinical Laboratory，the Second People’s Hospital of Yangzhou City(Huimin Hospital)，Jiangsu Yangzhou 225007，China；2.Department of Pediatrics，Subei People’s Hospital，Jiangsu Subei 225001，China；3.Department of Clinical Laboratory，the First People’s Hospital of Yangzhou，Jiangsu Yangzhou 225001，China
关键词:
支气管哮喘; 儿童; 白细胞介素; 体液免疫
分类号:
R562.25；R392.11
DOI:
10.3969/j.issn.1671-7414.2015.06.039
文献标志码:
A
摘要:
目的探讨哮喘患儿血清白介素与免疫球蛋白检测的临床意义。方法选取苏北人民医院2013年8月～2014年8月期间支气管哮喘住院患儿40例为研究对象，同时选取20例健康儿童为对照组。采用酶联免疫吸附试验对血清白介素(IL)进行测定；采用全自动散射比浊法对体液免疫进行检测。结果支气管哮喘患儿的IL-4，IL-5和IL-6含量(39.26±8.34 pg/ml，98.73±17.96 ng/L和204.32±50.84 pg/ml)与正常对照组(9.87±1.85 pg/ml，21.23±5.05 ng/L和101.22±37.63 pg/ml)相比均明显增高(t分别为2.79，2.83和3.09；P值均＜0.01)；而IL-10(11.33±4.01 pg/ml)与正常对照组(21.79±7.68 pg/ml)相比明显降低。体液免疫中，IgE(237.40±32.91 g/L)与正常对照组(71.66±18.57 g/L)相比明显增高(t=3.14，P＜0.01)；IgG(7.01±1.97 g/L)与正常对照组(10.32±2.01 g/L)相比明显降低；IgA(0.86±0.24 g/L），IgM（2.83±0.41 g/L)与正常对照组(0.72±0.23 g/L和3.29±0.58 g/L)相比变化不明显(P＞0.05)。结论哮喘患儿血清白介素与免疫球蛋白变化特点与病情相关，动态监测有助于支气管哮喘患儿临床诊断与治疗。
Abstract:
ObjectiveTo investigate the clinical significance of combined detection of serum interleukin and immune globulin in children with asthma．MethodsFrom August 2014 to August 2013，40 patients with bronchial asthma were selected as the research object，and 20 healthy children were selected as the control group．Serum interleukin (IL) were measured by enzyme linked immunosorbent assay，and immune globulin were measured by automatic scattering ratio turbidity method．ResultsThe bronchial asthma group’s interleukin，IL-4，IL-5 and IL-6 content (39.26±8.34 pg/ml，98.73±17.96 ng/L，204.32±50.84 pg/ml) were significantly higher than the control group (9.87±1.85 pg/ml，21.23±5.05 ng/L，101.22±37.63 pg/ml，t=2.79，2.83，3.09；P<0.01．IL-10 (11.33±4.01 pg/ml) was significantly lower than the control group (21.79±7.68 pg/ml)． IgE (237.40±32.91 g/L was significantly higher than the normal control group (71.66±18.57 g/L)(t=3.14，P＜0.01)；IgG (7.01±1.97 g/L) was significantly lower than the normal control group(10.32±2.01 g/L)．The changes in IgA，IgM(0.86±0.24 g/L，2.83±0.41 g/L)，and normal control group (0.72±0.23 g/L，3.29±0.58 g/L)　were not significant (P>0.05)．ConclusionSerum interleukin and immunoglobulin changes in children with asthma were related with the disease conditions．Dynamic monitoring can assist the clinical diagnosis and treatment of children with bronchial asthma．

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备注/Memo

备注/Memo:
作者简介：吉翔(1979-)，男，本科，主管检验技师，主要从事临床免疫研究，Tel：13912140556。
更新日期/Last Update: 1900-01-01