[1]李小龙,白巧艳,陆婉玲.老年非小细胞肺癌患者低分割放疗对凝血功能的影响[J].现代检验医学杂志,2018,33(05):142-144+148.[doi:10.3969/j.issn.1671-7414.2018.05.039]
　LI Xiao-long,BAI Qiao-yan,LU Wan-ling.Influence of Hypofractionated High-Dose Radiotherapy on Coagulation Function in Elderly Patients with Non-Small Cell Lung Cancer[J].Journal of Modern Laboratory Medicine,2018,33(05):142-144+148.[doi:10.3969/j.issn.1671-7414.2018.05.039]
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老年非小细胞肺癌患者低分割放疗对凝血功能的影响()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年05期
页码:
142-144+148
栏目:
检验与临床
出版日期:
2018-11-18

文章信息/Info

Title:
Influence of Hypofractionated High-Dose Radiotherapy on Coagulation Function in Elderly Patients with Non-Small Cell Lung Cancer
文章编号:
1671-7414(2018)05-142-04
作者:
李小龙1; 白巧艳2; 陆婉玲1
1.解放军第323医院肿瘤中心,西安 710054; 2.兵器工业五二一医院心内科,西安 710065
Author(s):
LI Xiao-long1; BAI Qiao-yan2; LU Wan-ling1
1.Oncology Center,No.323 Hospital of People's Liberation Army,Xi'an 710054,China; 2.Department of Vasculocardiology, No.521 Hospital of Ordnance Industry Institute,Xi'an 710065,China
关键词:
非小细胞肺癌;  低分割;  老年人;  凝血功能
分类号:
R734.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2018.05.039
文献标志码:
A
摘要:
目的 探讨老年非小细胞肺癌患者凝血功能的变化及低分割放疗对凝血功能的影响。方法 收集2013年1月～2016年3月在解放军第323医院首诊并仅接受胸部低分割放疗的老年非小细胞肺癌患者的临床资料,包含患者治疗前、后凝血功能指标:血浆凝血酶原时间(prothrombin time,PT)、纤维蛋白原(fibrinogen,Fib)、D-二聚体(D-dimer,D-D)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、血小板计数(platelet count,PLT),以及一般临床资料:性别、年龄、TNM分期和病理类型。三维适形低分割放疗方案,单次剂量2.5Gy,5次/周,总剂量35～50 Gy。结果 健康体检对照组共纳入39例,仅接受胸部放疗的老年非小细胞肺癌患者共纳入51例,老年肺癌组Fib,PLT和D-D水平明显高于对照组。老年非小细胞肺癌组患者的性别、年龄、病理分型对凝血功能影响差异无统计学意义(P>0.05); TNM分期中,Ⅲ～Ⅳ期较Ⅰ～Ⅱ期Fib和D-D明显升高,差异有统计学意义(t=-3.088,-2.218,均P<0.05)。放疗后1周Fib和D-D均显著高于放疗前,差异有统计学意义(t=-2.60,-2.57,均P<0.05)。结论 低分割三维适形放疗短期内加剧了老年非小细胞肺癌患者凝血功能亢进。
Abstract:
Objective To investigate influence of hypofractionated high-dose radiotherapy on coagulation function in elderly patients withnon-small cell lung cancer.Methods The clinical data of elderly patients with non-small cell lung cancer who were first diagnosed inNo.323 Hospital of People's Liberation Army from January 2013 to March 2016 and received only hypofractionated high-dose radiotherapy were collected,including the functional indexes of coagulation before and after treatment:prothrombin time(PT),fibrinogen(Fib),D-dimer,activated partial thromboplastin time(APTT),platelet count(PLT),and clinical data of all patients:sex,age,TNMstage and pathological type.Dose fractionation 2.5Gy/d,5f/w,total dose 35Gy～55Gy.Results Levels of Fib,PLT and D-D in lung cancer group were significantly higher than the control group(P<0.05).Sex,age and pathological on coagulation function in elderly patients with non-smallcell lung cancer were no significantly higher(P>0.05).Levels of Fib andD-D in Ⅲ～Ⅳ stage were significantly higher than Ⅰ～Ⅱ stage(t=-3.088,-2.218,all P<0.05).The level of Fib and D-D at the time points of 1weeks after hypofractionated high-dose radiotherapy were significantly higher than those at the time point of 0 week after hypofractionated high-dose radiotherapy(t=-2.60,-2.51,all P<0.05).Conclusion Three-dimensional conformal hypofractionated high-dose radiotherapy may aggravate the augmentation of coagulation function in elderly patients with non-small cell lung cancer in the short term.

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备注/Memo

备注/Memo:
基金项目:陕西省社会发展科技攻关项目(编号:2015SF060)。
作者简介:李小龙(1982-),男,硕士,主治医师,主要从事头颈部及胸部肿瘤的放射治疗工作,E-mail:lixiaolong1216@163.com。
通讯作者:陆婉玲(1973-),女,主任医师,主要从事头颈部及胸部肿瘤的综合治疗工作,E-mail:lwldst@sina.com。
更新日期/Last Update: 2018-09-30