[1]罗改莹a,王 瑞b,周 辉b,等.类风湿性关节炎患者血清RF-IgM,RF-IgG检测的临床诊断价值[J].现代检验医学杂志,2018,33(06):43-45+49.[doi:10.3969/j.issn.1671-7414.2018.06.011]
　LUO Gai-yinga,WANG Ruib,ZHOU Huib,et al.Clinical Diagnostic Value of Serum RF-IgM and RF-IgG in Patients with Rheumatoid Arthritis[J].Journal of Modern Laboratory Medicine,2018,33(06):43-45+49.[doi:10.3969/j.issn.1671-7414.2018.06.011]
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类风湿性关节炎患者血清RF-IgM,RF-IgG检测的临床诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年06期
页码:
43-45+49
栏目:
论著
出版日期:
2018-12-24

文章信息/Info

Title:
Clinical Diagnostic Value of Serum RF-IgM and RF-IgG in Patients with Rheumatoid Arthritis
文章编号:
1671-7414(2018)06-043-04
作者:
罗改莹1a; 王 瑞1b; 周 辉1b; 来艳君2
1.西安市第五医院a.检验科; b.内科五病区,西安 710082; 2.西安市第九医院检验科,西安 710054
Author(s):
LUO Gai-ying1a; WANG Rui1b; ZHOU Hui1b; LAI Yan-jun2
1a.Department of Clinical Laboratory; 1b.the Fifth Ward of Department of Internal Medicine,Xi'an Fifth Hospital,Xi'an 710082, China; 2.Department of Clinical Laboratory,Xi'an Ninth Hospital,Xi'an710054,China
关键词:
类风湿性关节炎;  类风湿因子(IgM);  类风湿因子(IgG);  类风湿因子;  D-二聚体;  红细胞沉降率
分类号:
R593.22; R392.11
DOI:
10.3969/j.issn.1671-7414.2018.06.011
文献标志码:
A
摘要:
目的 观察类风湿因子IgM(RF-IgM)、类风湿因子IgG(RF-IgG)在类风湿性关节炎(RA)患者诊疗中的临床应用及预后判断价值。方法 选取西安市第五医院就诊的RA患者,将其中RF-IgM和RF-IgG阳性患者列为观察组(n=52),RF-IgM和RF-IgG阴性患者列为对照组(n=46),健康体检者列为健康组(n=50),分别在治疗前、治疗6个月后检测各组血浆D-二聚体(D-Dimer,DD)、纤维蛋白降解产物(fibrin degradation products,FDP)、红细胞沉降率(ESR)及类风湿因子(rheumatoid factor,RF),以及在治疗6个月后对观察组与对照组进行视觉模拟疼痛(VAS)评分、晨僵时间(min)及关节压痛数的疗效评价。结果 治疗前观察组和对照组患者的DD及FDP水平均显著高于健康组,两两比较差异均有统计学意义(t=29.348～132.341,均P<0.05; t=46.307～113.222,均P<0.05)。观察组、对照组分别与健康组两两比较,ESR和RF指标差异均无统计学意义(t=0.025～0.161,P>0.05; χ2=0.572～2.842,P>0.05)。治疗6个月后观察组患者FDP,DD指标明显高于对照组,且差异均具有统计学意义(t=20.3,66.381,P<0.05)。观察组患者ESR和RF指标与对照组比较,差异也具有统计学意义(χ2=6.152,4.104,P<0.05)。将两组患者间的VAS评分、晨僵时间(min)、关节压痛数(个)进行比较,差异均有统计学意义(t=23.966,23.530,25.516,均P<0.05)。结论 RF-IgM,RF-IgG阴性的RA患者在接受标准抗风湿治疗后各检测指标及功能改善方面均优于RF-IgM,RF-IgG阳性的RA患者,RF-IgM,RF-IgG检测能够为RA疾病的预后判断提供一定的临床诊断价值。
Abstract:
Objective To observe the clinical application and prognostic value of rheumatoid factor IgM(RF-IgM)and rheumatoid factor IgG(RF-IgG)in the diagnosis and treatment.Methods Patients with RA were diagnosed in the Fifth Hospital of Xi'an were selected.The patients with positive RF-IgM and RF-IgG were divided into observation group(n=52),and RF-IgM,RF-IgG negative patients were divided into control group(n=46).Healthy volunteers were as healthy group(n=50).The plasma D-dimer(DD),fibrin degradation products(FDP),erythrocyte sedimentation rate(ESR)and rheumatoid factor(RF)were measured before and after six months treatment.Visual analogue pain(VAS),morning stiffness time(min)and joint tenderness were evaluated in the observation group and the control group after six monthsof treatment.Results Before treatment,the plasma DD and FDP levels of the observation group and the control group were significantly higher than those of the healthy group,and there was significant difference between the two groups(t=29.348～132.341,all P<0.05; t=46.307～113.222,all P<0.05).In the observation group,the control group and the healthy group,there was no significant difference in ESR and RF indexes(t=0.025～0.161,P>0.05; χ2=0.572～2.842,all P>0.05).After 6 months of treatment,the FDP and DD indexes in the observation group were significantly higher than those in the control group(t=20.3,66.381,P<0.05),and the ESR and RF indexes in the observation group were significantly higher than thosein the control group(χ2=6.152,4.104,P<0.05).The VAS score,morningstiffness time(min)and joint tenderness(number)between the two groups werecompared,and the difference was statistically significant(t=23.966,23.530,25.516,P<0.05).Conclusion RF-IgM and RF-IgG negative RA patients were better than RF-IgM in terms of detection index and function improvement after standard antirheumatic treatment.RF-IgG positive RA patients,RF-IgM,RF-IgG detection can provide certain clinical diagnostic value for the prognosis of RA disease.

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备注/Memo

备注/Memo:
作者简介:罗改莹(1978-),女,本科,副主任技师,主要从事临床免疫学检验,Tel:13689268185,E-mail:1109107091@qq.com。
通讯作者:来艳君,女,本科,副主任技师,E-mail:402212439@qq.com。
更新日期/Last Update: 2018-11-30