[1]韦 莉,缪淑贤,王 敏,等.胰腺癌患者血清尿酸、肌酐水平检测及尿酸/肌酐比值的临床意义[J].现代检验医学杂志,2019,34(04):99-102.[doi:10.3969/j.issn.1671-7414.2019.04.024]
 WEI Li,MIAO Shu-xian,WANG Min,et al.Clinical Significance of Serum Uric Acid,Creatinine and Uric Acid/Creatinine Ratio in Pancreatic Ductal Adenocarcinoma[J].Journal of Modern Laboratory Medicine,2019,34(04):99-102.[doi:10.3969/j.issn.1671-7414.2019.04.024]
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胰腺癌患者血清尿酸、肌酐水平检测及尿酸/肌酐比值的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
99-102
栏目:
论著
出版日期:
2019-08-20

文章信息/Info

Title:
Clinical Significance of Serum Uric Acid,Creatinine and Uric Acid/Creatinine Ratio in Pancreatic Ductal Adenocarcinoma
文章编号:
1671-7414(2019)04-099-04
作者:
韦 莉缪淑贤王 敏张 伟
(南京医科大学第一附属医院检验学部,南京 210029)
Author(s):
WEI LiMIAO Shu-xianWANG MinZHANG Wei
(Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
关键词:
胰腺癌 尿酸 肌酐 尿酸/肌酐比值
分类号:
R735.9; R730.43
DOI:
10.3969/j.issn.1671-7414.2019.04.024
文献标志码:
A
摘要:
目的 研究血生化指标尿酸(UA)、肌酐(Cr)水平及尿酸/肌酐比值(UA/Cr比值)在胰腺癌(pancreatic ductal adenocarcinoma,PDAC)中的水平,了解其与临床病理特征的关系,并探讨其可能的机制。方法 收集2017年5月~2018年8月南京医科大学第一附属医院胰胆中心收治并经组织病理确诊的282例胰腺癌患者和58例胰腺良性肿瘤患者。并收集同期间200例健康体检者。采用Beckman Coulter AU5800生化分析仪检测血清UA和Cr水平,同时分析UA,Cr水平和UA/Cr比值与胰腺癌临床病理特征之间的关系。结果 血清UA,Cr水平及UA/Cr比值在胰腺癌组与胰腺良性肿瘤组、正常对照组比较,差异均有统计学意义(FZ=-6.78111.175,P<0.05),而UA和UA/Cr比值在良性肿瘤组和正常对照组之间比较,差异均无统计学意义(FZ=-1.88811.559,P>0.05),Cr水平在良性肿瘤组和正常对照组之间比较,差异有统计学意义(F=2.121,P<0.05)。血清UA,Cr水平和UA/Cr比值与胰腺癌患者性别、肿瘤部位有关(TZ=-9.17817.986,P<0.05),UA/Cr比值还与胰腺癌患者年龄有关(Z=-2.294,P<0.05)。三者均与肿瘤最大径、临床分期、病理分级、淋巴结转移及远处转移无关(TZ=-1.4522.214,P>0.05)。结论 UA水平在胰腺癌患者中显著降低,机体抗氧化能力在肿瘤发生中作用很大,UA/Cr比值能更好地反映老年胰腺癌患者体内的抗氧化能力。但两者均不能作为独立的指标对胰腺癌进行早期检测和诊断。
Abstract:
Objective To evaluate the level of serum uricacid(UA),creatinine(Cr)and uric acid/ creatinine ratio(UA/Cr ratio)in pancreatic ductal adenocarcinoma(PDAC)and explore its possible mechanism.Methods 282 cases of PDAC and 58 cases of benign pancreatic tumor diagnosed in histopathology from May 2017 to April 2018 in the First Affiliated Hospital of Nanjing Medical University of pancreatic biliary center were studied.Meanwhile,200 cases of healthy people at the same period were also studied.Serum UA and creatinine(Cr)were detected with Beckman Coulter AU5800 biochemical analyzer,and then the relationship among UA,Cr,UA/Cr ratio and the clinicopathological features was analyzed.Results The level of serumUA,Cr and UA/Cr ratio in PDAC group were significantly lower than the benign tumor group and the control group(F or Z=-6.781~11.175,all P<0.05).Meanwhile,the level of UA and UA/Cr ratio had no significiances betweenbenign tumor group and control group(F or Z=-1.888~11.559,all P>0.05),but the level of Cr was opposite(F=2.121,P<0.05).UA,Cr andUA/Cr ratio were associated with sex,tumor position(F or Z=-9.178~ 17.986,all P<0.05),but had nothing to do with age,tumor size,clinicalstage,pathology grade,lymphatic metastasis and distant metastasis(F or Z=-1.136~2.214,all P>0.05).Meanwhile,UA/Cr ratio was also related to the age(Z=-2.294,P<0.05).Conclusion The levelof UA was significient reduced in PDAC which showed great importance of its antioxidant capacity in tumorigenesis.UA/Cr ratio can reflect the antioxidant capacity of elderly patients better.However,neither of them can be used as independent indicators for early detection and diagnosis of PDAC.

参考文献/References:

[1] SOERJOMATARAM I, LORTER-TIEULENT J,P-ARKIN D M,et al.Global burden of cancer in 2008:a systematic analysis of disability-adjusted life-years in 12 word regions[J].Lancet,2012,380(9856):1840-1850. [2] FERLAY J,SOERJOMATARAM I,DIKSHIT R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):E359-E386. [3] LIN Quanjun,YANG Feng,JIN Chen,et al.Current status and progress of pancreatic cancer in China[J].World J Gastroenterol,2015,21(26):7988-8003. [4] SAKAMOTO T,SAITO H,UCHINAKA E I,et al.The combination of neutrophil-to-lymphocyte ratio and serum carbohydrate antigen 19-9 level as a prognosticindicator in patients with recurrent pancreatic cancer[J].Anticancer Research,2018,38(9):5497-5503. [5] YU Jinming,DING Zhaoyan,YANG Yuanming,et al.Increased platelet-to-lymphoctes ratio is associated with poor long-term prognosis in patients with pancreatic cancer after surgey[J].Medicine(Baltimore),2018,97(25):e11002. [6] LANASPA M A,SANCHEZ-LOZADA L G,CHOI Y J,et al.Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress:potential role infructose-dependent and independent fatty liver[J].The Journal of BiologicalChemistry,2012,287(48):40732-40744. [7] FABBRINI E,SWRAFINI M,COLIC BARIC I,et al.Effect of plasma uric acidon antioxidant capacity,oxidative stress,and insulin sensitivity in obese subjects[J].Diabetes,2014,63(3):976-981. [8] LIOU G Y,STORZ P.Reacitve oxygen species in ca-ncer[J].Free Radic Rec,2010,44(5):479-496. [9] AMES B N,CATHCART R,SCHWIERS E,et al.Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer:a hypothesis[J].Proc Natl Acad Sci USA,1981,78(11):6858-6862. [10] YUE Caifeng,FENG Pinning,YAO Zhenrong,et al.High serum uricacid concentration predicts poor survival in patients with breast cancer[J].Clin Chim Acta,2017,473:160-165. [11] STOTZ M,SZKANDERA J,SEIDEL J,et al.Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients[J].PLoS One,2014,9(8):e104730. [12] TANRIVERDI O,COKMERT S,OKTAY E,et al.Prognostic significance of thebaseline serum uric acid level in non-small cell lung cancer patients treated with first-line chemotherapy:a study of the Turkish Descriptive Oncological Researches Group[J].Med Oncol,2014,31(10):217. [13] FINI M A,ELIAS A,JOHNSON R J,et al.Contribution of uric acid to cancer risk,recurrence,and mortality[J].Clin Transl Mel,2012,1(1):16. [14] 段敏,赵海建,王薇,等.临床检验参考区间的决定限的质量要求[J].现代检验医学杂志,2017,32(5):148-151. DUAN Min, ZHAO Haijian, WANG Wei, et al.Quality requirements for reference intervals and decision limits in clinical laboratory[J].J Mod Lab Med,2017,32(5):148-151. [15] ZHONG Chongke, ZHONG Xiaoyan, XU Tian,et al.Sex-specific relationshipbetween serum uric acid and risk of stroke:A dose-response meta-amalysis ofprospective studies[J].J Am Heart Assoc,2017,6(4):e005042. [16] GAO Xiang,O'REILLY E J,SCHWARZSCHILD M A,et al.Prospective study ofplasma urate and risk of parkinson disease in men and women[J].Neurology,2016,86(6):520-526. [17] MOCCIA M,PELLECCHIA MT,SPINA E,et al.Bilirubin and uric acid:two different anti- oxidants in Parkinson's disease[J].Cell Biochem Biophys,2016,74(2):91-92. [18] LAPENNA D,CIOFANI G,PIERDOMENICO S D,et al.Association of serum bilirubin with oxidant damage of human atherosclerotic plaques and the severity of atherosclerosis[J].Clin Exp Med,2018,18(1):119-124. [19] TANG Linghui,HUANG Cheng,FENG Yingqing.Serum total bilirubin concentration is associated with carotid atherosclerosis in patients with prehypertension[J].Clin Exp Hypertens,2018,oct.30:1-5.doi.10.1080110641963.2018.1539094.[Epub ahead of print]

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备注/Memo

备注/Memo:
基金项目:江苏省实验诊断学重点实验室(ZDXKB2016005)。 作者简介:韦 莉(1984-),女,本科,主管技师,主要从事胰腺癌早期诊断及胰腺相关疾病方面的研究,E-mail:weili864@163.com。 通讯作者:张 伟,E-mail:zhang_wei@njmu.edu.cn。 收稿日期:2019-04-28 修回日期:2019-05-16
更新日期/Last Update: 2019-07-30