[1]王阳斌,夏　茂,夏永泉.血浆 vWF，D-二聚体水平与外周血中性粒细胞 /淋巴细胞比值联合检测在血栓性疾病中的临床诊断价值[J].现代检验医学杂志,2019,34(06):86-89.[doi:10.3969 ／ j.issn.1671-7414.2019.06.021]
　WANG Yang-bin,XIA Mao,XIA Yong-quan.Diagnostic Value of vWF Combined with D-Dimer and Peripheral Blood NLR in the Diagnosis of Thrombotic Disease[J].Journal of Modern Laboratory Medicine,2019,34(06):86-89.[doi:10.3969 ／ j.issn.1671-7414.2019.06.021]
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血浆 vWF，D-二聚体水平与外周血中性粒细胞 /淋巴细胞比值联合检测在血栓性疾病中的临床诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
86-89
栏目:
论著
出版日期:
2019-12-30

文章信息/Info

Title:
Diagnostic Value of vWF Combined with D-Dimer and Peripheral Blood NLR in the Diagnosis of Thrombotic Disease
文章编号:
1671-7414（2019）06-086-04
作者:
王阳斌; 夏　茂; 夏永泉
（南京大学医学院附属鼓楼医院检验科，南京　210008）
Author(s):
WANG Yang-bin; XIA Mao;  XIA Yong-quan
（Department of Laboratory Medicine, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China）
关键词:
血浆血管性血友病因子; D- 二聚体; 中性粒细胞与淋巴细胞比值; 血栓性疾病
分类号:
R54；R446.11
DOI:
10.3969 ／ j.issn.1671-7414.2019.06.021
文献标志码:
A
摘要:
目的　探讨血浆血管性血友病因子（von willeBrand factor，vWF），D- 二聚体（D-Dimer，D-D）和外周血 中性粒细胞/ 淋巴细胞比值（NLR）联合检测在血栓性疾病中的临床应用价值。方法　检测52 例血栓性疾病患者和 42 例非血栓性疾病患者的vWF ，D-D 与NLR 水平，采用受试者工作特征（ROC）曲线计算vWF ，D-D 与NLR 单独 及联合检测时，在诊断血栓性疾病中的诊断临界值、曲线下面积（AUC）、敏感度和特异度。结果　血栓性疾病组患 者的血浆vWF，D-D 与NLR 均高于非血栓组，差异均有统计学意义（t =2.988~5.398，均P <0.05）。ROC 曲线分析表 明，vWF ，D-D 与NLR 的诊断临界值分别设定为136.85%，1.14mg/L 和2.857 时，其在诊断血栓性疾病中的ROC 曲 线下面积（AUC）分别为0.783，0.720 和0.766，灵敏度分别为78.85%，63.46% 和73.08%，特异度分别为76.19%， 76.20% 和71.43%。vWF, D-D 与NLR 联合诊断血栓性疾病的AUC 为0.82，灵敏度为82.69%，特异度为71.43%。结论　 vWF，D-D 与NLR 升高与血栓性疾病的发生存在明显相关性，联合检测优于各单独指标的应用。
Abstract:
Objective　To investigate the diagnostic value of vWF combined with D-Dimer and NLR in serum of patients with thrombotic disease. Methods　The results of vWF, D-D and NLR were detected in 52 patients with thrombotic disease (thrombotic disease group) and 42 patients with non-thrombotic disease (non-thrombotic disease group) were detected. The receiver operating characteristic (ROC) curve was used to calculate the diagnostic threshold, area undeer the curve （AUC） diagnostic sensitivity and specificity of vWF, D-D and NLR in the diagnosis of thrombotic diseases when used alone or in combination. Results　The sera levels of vWF, D-Dimer and NLR in thrombotic disease group were all higher than those in control group, the difference were statistically significant (t =2.988~5.398，all P <0.05). ROC curve analysis showed that with the critical value of vWF, D-Dimer and NLR in serum were 136.85%, 1.14mg/L and 2.857 respectively. In the diagnosis of thrombotic disease, the area under the ROC curve (AUC) were 0.783，0.720 and 0.766 respectively. The AUC of vWF combined with D-Dimer and NLR in the diagnosis of thrombotic disease was 0.82, the sensitivity and specificity were 82.69% and 71.43% respectively. Conclusion　The elevation of vWF, D-D and NLR was significantly correlated with the occurrence of thrombotic diseases, and the combined detection was superior to the application of individual indicators.

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备注/Memo

备注/Memo:
作者简介：王阳斌(1976-)，男，学士，技师，主要从事检验技术研究，E-mail: 438090040@qq.com。 通讯作者：夏永泉，男，副主任技师，主要从事检验技术研究，E-mail:xyq2002xyq@aliyun.com 收稿日期：2019-08-11
更新日期/Last Update: 2019-12-25