[1]毛 俊,王 柯.老年肺癌患者肺切除术后血液 CRP,D- 二聚体,IL-17 水平与并发急性呼吸衰竭的相关性研究[J].现代检验医学杂志,2021,36(03):83-87.[doi:10.3969/j.issn.1671-7414.2021.03.019]
 MAO Jun,WANG Ke.Correlation of Blood CRP, D-dimer and IL-17 Levels with Acute RespiratoryFailure in Elderly Patients with Lung Cancer after Pneumonectomy[J].Journal of Modern Laboratory Medicine,2021,36(03):83-87.[doi:10.3969/j.issn.1671-7414.2021.03.019]
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老年肺癌患者肺切除术后血液 CRP,D- 二聚体,IL-17 水平与并发急性呼吸衰竭的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
83-87
栏目:
论 著
出版日期:
2021-05-31

文章信息/Info

Title:
Correlation of Blood CRP, D-dimer and IL-17 Levels with Acute RespiratoryFailure in Elderly Patients with Lung Cancer after Pneumonectomy
文章编号:
1671-7414(2021)03-083-05
作者:
毛 俊王 柯
(1. 武汉市优抚医院检验科 , 武汉 430021;2. 武汉市金银潭医院北 5 病区 , 武汉 430023)
Author(s):
MAO Jun1WANG Ke2
(1. Department of Clinical Laboratory, Wuhan Special Care Hospital, Wuhan 430021, China;2. North 5 Ward, JinyintanHospital in Wuhan City, Wuhan 430023, China)
关键词:
C 反应蛋白D- 二聚体白介素 -17肺癌呼吸衰竭
分类号:
R734.2;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.03.019
文献标志码:
A
摘要:
目的 探讨血液 C 反应蛋白(CRP),D- 二聚体和白介素 -17(IL-17)与老年肺癌患者肺切除术后并发急性呼吸衰竭(ARF)的相关性。方法 选择 2017 年 6 月 ~2020 年 7 月武汉市优抚医院收治的 311 例老年肺癌患者,258例术后未并发 ARF 者(NARF 组),53 例术后并发 ARF(ARF 组),其中 19 例Ⅰ型 ARF(Ⅰ型 ARF 组),34 例Ⅱ型ARF(Ⅱ型 ARF 组),18 例轻度 ARF(轻度组 PaO240~59mmHg),20 例中度 ARF(中度组 PaO235~39mmHg)和 15例重度 ARF(重度组 PaO2 < 35mmHg)。比较不同分组血液 CRP,D- 二聚体和 IL-17 水平差异,二元 Logistic 回归分析 CRP,D- 二聚体,IL-17 与老年肺癌患者术后并发 ARF 的相关性。结果 ARF 组 COPD 病史、解剖性肺切除术比例、动脉二氧化碳分压(PaCO2)、血液 CRP,D- 二聚体和 IL-17 水平均高于 NARF 组,差异均有统计学意义(χ2=9.238,4.856,27.772,t=39.114,P < 0.05),动脉氧分压(PaO2)、氧合指数(PaO2/FiO2)低于 NARF 组(χ2=-39.887,14.242,均 P < 0.05)。Ⅱ型 ARF 组血液 CRP,D- 二聚体,IL-17 水平均高于Ⅰ型 ARF 组(t=-10.065,-16.292,-17.335,均 P < 0.05),重度组血液 CRP,D- 二聚体,IL-17 水平高于中度和轻度组(t=3.121,9.327,2.870 和 25.337,10.385,12.331,均 P < 0.05),中度组高于轻度组(t=4.717,3.228,3.752,均 P < 0.05)。二元 Logistic 回归分析结果显示高水平 CRP ,D- 二聚体,IL-17 以及 COPD 病史是肺癌术后并发 ARF 的危险因素(P < 0.01)。结论 老年肺癌术后并发 ARF 患者血液 CRP ,D二聚体,IL-17 水平显著升高,CRP ,D- 二聚体,IL-17 水平升高与 ARF 发生和病情严重程度均密切相关。

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备注/Memo

备注/Memo:
基金项目:湖北省卫健委联合基金(WJ2019H461)。
作者简介:毛俊 (1982-) , 男 , 本科 , 主管检验师 , 研究方向:免疫和分子生物 ,E-mail:240690712@qq.com。
通讯作者:王珂 (1976-) , 男 , 本科 , 主治医师 , 研究方向:呼吸内科 ,E-mail:370970179@qq.com。
更新日期/Last Update: 1900-01-01