[1]任继欣,郭彦言.外周血HBP,IL-6,CD64 指数,PCT,CRP 和SAA 水平检测在血流感染诊断中的应用价值研究[J].现代检验医学杂志,2020,35(02):56-59.[doi:10.3969/j.issn.1671-7414.2020.02.017]
 REN Ji-xin,GUO Yan-yan.Application Value of Peripheral Blood HBP, Interleukin-6, CD64 Index, PCT,CRP ,SAA Level Detection in Blood Stream Infection Diagnosis[J].Journal of Modern Laboratory Medicine,2020,35(02):56-59.[doi:10.3969/j.issn.1671-7414.2020.02.017]
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外周血HBP,IL-6,CD64 指数,PCT,CRP 和SAA 水平检测在血流感染诊断中的应用价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
56-59
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Application Value of Peripheral Blood HBP, Interleukin-6, CD64 Index, PCT,CRP ,SAA Level Detection in Blood Stream Infection Diagnosis
文章编号:
1671-7414(2020)02-056-04
作者:
任继欣1郭彦言2
(1. 唐山市丰润区中医医院检验科,河北唐山 064000;2. 唐山市工人医院检验科,河北唐山 063000)
Author(s):
REN Ji-xin1 GUO Yan-yan2
(1.Department of Clinical Laboratory,Tradilional Chinese Medicine Hospital of Fengrun District in Tangshan City, HebeiTangshan 064000,China , 2.Department of Clinical Laboratory, Tangshan Works Hospital ,Hebei Tangshan 063000,China)
关键词:
肝素结合蛋白白介素-6降钙素原C 反应蛋白血流感染
分类号:
R631;R446.11
DOI:
10.3969/j.issn.1671-7414.2020.02.017
文献标志码:
A
摘要:
目的 分析比较外周血中肝素结合蛋白(HBP)、白介素-6(IL-6)、中性粒细胞CD64 指数、降钙素原(PCT)、C 反应蛋白(CRP) 和血清淀粉样蛋白A(SAA)在血流感染(bloodstream infection, BSI) 诊断中尤其在感染早期的诊断价值。方法 收集2018 年度血培养阳性并确诊为血流感染的患者95 例,将其分为两组:细菌感染组75 例,真菌感染组20 例,并选取健康体检者100 例作为对照组,分别测定三组的HBP,IL-6,CD64 指数,PCT,CRP 和SAA水平。 结果 与健康对照组比较,血流感染组HBP,IL-6,CD64 指数,PCT,CRP 和SAA 浓度水平显著性升高,差异均有统计学意义(t=6.14~14.61, 均P < 0.01)。与真菌感染组比较,细菌感染组各指标浓度水平升高,差异均有统计学意义(t=8.39~15.72, 均P < 0.01);HBP,IL-6,CD64 指数,PCT,CRP,SAA 诊断血流感染的AUC 分别为0.903,0.813,0.798,0.856,0.751 和0.822,相比较诊断价值最佳的依次是:HBP,PCT,SAA ,IL-6,CD64指数和CRP 。结论 外周血多种因子在血流感染中均具有一定的诊断价值,在血流感染的早期以HBP, PCT,SAA的敏感度和特异度较好,诊断价值较高。

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备注/Memo

备注/Memo:
作者简介:任继欣(1977-),女,大学本科,副主任技师,研究方向:临床基础检验,E-mail:rjx779240@163.com。收稿日期:2019-09-30修回日期:2019-11-29
更新日期/Last Update: 2020-04-30