[1]刘小莉,张 静,张红梅.类风湿关节炎患者血浆FDP 和DD 水平与疾病活动性的相关性研究[J].现代检验医学杂志,2020,35(02):60-64.[doi:10.3969/j.issn.1671-7414.2020.02.018]
 LIU Xiao-li,ZHANG Jing,ZHANG Hong-mei.Correlation between Plasma FDP, DD Levels and Disease Activity in Patientswith Rheumatoid Arthritis[J].Journal of Modern Laboratory Medicine,2020,35(02):60-64.[doi:10.3969/j.issn.1671-7414.2020.02.018]
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类风湿关节炎患者血浆FDP 和DD 水平与疾病活动性的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
60-64
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Correlation between Plasma FDP, DD Levels and Disease Activity in Patientswith Rheumatoid Arthritis
文章编号:
1671-7414(2020)02-060-05
作者:
刘小莉张 静张红梅
(四川省骨科医院检验科,成都 610041)
Author(s):
LIU Xiao-liZHANG JingZHANG Hong-mei
(Department of Chinical Laboratory,Sichuan Provincial Orthopedic Hospital, Chengdu 610041,China)
关键词:
纤维蛋白(原)降解产物D- 二聚体类风湿关节炎
分类号:
R593.22;R392.11
DOI:
10.3969/j.issn.1671-7414.2020.02.018
文献标志码:
A
摘要:
目的 探讨类风湿关节炎(RA)患者血浆中纤维蛋白(原)降解产物(FDP)和D- 二聚体(DD)水平与疾病活动性的相关性。方法 选择2018 年1~12 月在四川省骨科医院住院并诊断为RA 的患者71 例,并收集患者的临床资料。根据DAS28 评分将RA 患者分为病情稳定组(DAS28 ≤ 2.6 分)和病情活动组(DAS28>2.6 分)。收集同期体检者65例作为对照组,检测FDP,DD,类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体、补体3(C3)、补体4(C4)、红细胞沉降率(ESR)和C- 反应蛋白(CRP)水平。比较两组FDP 和DD 水平,分析FDP,DD 与其他指标的相关性,并对FDP,DD 单独和联合诊断RA 的受试者工作(ROC)曲线分析,探讨FDP,DD 与RA 患者病情活动性的相关性。结果 RA 患者组FDP,DD 水平高于对照组(U=520,741, 均P < 0.05),且病情活动组FDP,DD,ESR,CRP,C3 和DAS28评分均高于稳定组,差异有统计学意义(U=26,P<0.001;U=58,P<0.001;t=6.273,P < 0.001;U=146.5,P < 0.001;t=2.047,P=0.0452;t=9.90,P < 0.001)。RA 患者血浆中FDP 水平与DAS28 评分、CRP ,ESR 均呈正相关性(r=0.861 1,0.642 1,0.704 9,均P < 0.05);DD 与DAS28 评分、RF,CRP,ESR,C3 均呈正相关性(r=0.844,0.383 2,0.693 1,0.640 2,0.257 5,均P < 0.05)。根据ROC 曲线,FDP 和DD 单独检测诊断RA 的曲线下面积(AUC)分别为0.839 4 和0.862,敏感度和特异度分别为95.38%,69.01% 和92.65%,75.04%,两者联合检测诊断RA 的AUC 为0.887 3,敏感度和特异度分别为96.92%,76.06%。结论 RA 患者FDP,DD 水平显著升高并与疾病活动度相关,且两项指标联合检测可作为监测RA 疾病活动度的参考指标。

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备注/Memo

备注/Memo:
作者简介:刘小莉(1988-),女,硕士研究生,检验师,主要从事自身免疫性疾病实验室诊断,E-mail:236550934@qq.com。收稿日期:2019-09-16修回日期:2019-11-05
更新日期/Last Update: 2020-04-30