[1]李 艳,李新宇.妊娠糖尿病患者外周血miRNA-21 检测的临床应用价值[J].现代检验医学杂志,2020,35(02):35-38.[doi:10.3969/j.issn.1671-7414.2020.02.011]
 LI Yan,LI Xin-yu.Clinical Application Value of Detection of miRNA-21 in Peripheral Blood ofPatients with Gestational Diabetes[J].Journal of Modern Laboratory Medicine,2020,35(02):35-38.[doi:10.3969/j.issn.1671-7414.2020.02.011]
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妊娠糖尿病患者外周血miRNA-21 检测的临床应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
35-38
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Clinical Application Value of Detection of miRNA-21 in Peripheral Blood ofPatients with Gestational Diabetes
文章编号:
1671-7414(2020)02-035-04
作者:
李 艳1李新宇2
(1. 榆林市第三医院妇产科,陕西榆林 719000;2. 宝鸡市妇幼保健院检验科, 陕西宝鸡 721000)
Author(s):
LI Yan1 LI Xin-yu2
(1. Department of Obstetrics and Gynecology, the Third Hospital of Yulin City, Shaanxi Yulin 719000, China;2. Department of Clinical Laboratory, Baoji Maternal and Child Health Hospital, Shaanxi Baoji 721000, China )
关键词:
外周血miRNA-21妊娠糖尿病血糖
分类号:
R714.256;R392.11
DOI:
10.3969/j.issn.1671-7414.2020.02.011
文献标志码:
A
摘要:
目的 探讨妊娠糖尿病患者外周血miRNA-21 检测的临床应用价值。方法 选择2016 年9 月~ 2019 年3 月榆林市第三医院妇产科收治的妊娠糖尿病(gestational diabetes mellitus, GDM)孕妇作为GDM 组,选择同期在榆林市第三医院进行健康体检的非妊娠糖尿病孕妇为对照组,两组各79 例。采集两组受试孕妇外周血,检测空腹血糖、餐后2h 血糖值以及miRNA-21 表达水平并进行相关性分析。结果 GDM 组孕妇的空腹血糖水平、餐后2h 血糖水平以及外周血miRNA-21 相对表达水平均高于对照组,差异具有统计学意义(t=45.652,16.663,148.541,均P<0.05);Spearman 相关分析显示外周血中miRNA-21 相对表达水平与空腹血糖、餐后2h 血糖均呈显著正相关性(r=0.655,0.732, 均P<0.05);二分类Logistic 回归分析显示空腹血糖、餐后2h 血糖、外周血miRNA-21 均为导致妊娠糖尿病发病的显著影响因素(P<0.05)。结论 孕妇外周血miRNA-21 水平一定程度上可作为其是否患妊娠糖尿病的判断依据。

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备注/Memo

备注/Memo:
作者简介: 李艳(1983-),女,本科,主治医师,研究方向:妇产科,E-mail:lilyyan6688@sina.com。通讯作者: 李新宇(1973-),男,本科,副主任检验师,研究方向:临床检验,E-mail:734641969@qq.com。收稿日期:2019-08-23修回日期:2019-10-15
更新日期/Last Update: 2020-04-30