[1]刘 涛,杨 燕,刘 博,等.联合检测胸腹腔积液sCD44V6,CEA,CYFRA21-1,CA199,NSE,CA125 对良恶性疾病鉴别诊断价值研究[J].现代检验医学杂志,2020,35(02):53-55.[doi:10.3969/j.issn.1671-7414.2020.02.016]
 LIU Tao,YANG Yan,LIU Bo,et al.Value of Combined Detection of sCD44V6, CEA,CYFRA21-1,CA199,NSEand CA125 in the Differential Diagnosis of Benign and MalignantPleural and Peritoneal Effusion[J].Journal of Modern Laboratory Medicine,2020,35(02):53-55.[doi:10.3969/j.issn.1671-7414.2020.02.016]
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联合检测胸腹腔积液sCD44V6,CEA,CYFRA21-1,CA199,NSE,CA125 对良恶性疾病鉴别诊断价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
53-55
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Value of Combined Detection of sCD44V6, CEA,CYFRA21-1,CA199,NSEand CA125 in the Differential Diagnosis of Benign and MalignantPleural and Peritoneal Effusion
文章编号:
1671-7414(2020)02-053-04
作者:
刘 涛1 杨 燕2 刘 博1 王剑锋1
(1.铜川市人民医院,陕西铜川 727031;2.北京中医药大学孙思邈医院,陕西铜川 727031)
Author(s):
LIU Tao1YANG Yan2LIU Bo1WANG Jian-feng1
(1.Tongchuan People’s Hospital,Shaanxi Tongchuan 727031,China;2.Sun Simiao Hospital of Beijing University ofTraditional Chinese Medicine,Shaanxi Tongchuan 727031,China)
关键词:
胸腹腔积液可溶性CD44V6癌胚抗原非小细胞肺癌相关抗原细胞角蛋白19糖链抗原199神经原特异烯醇化酶糖链抗原 良恶性疾病
分类号:
R446.19
DOI:
10.3969/j.issn.1671-7414.2020.02.016
文献标志码:
A
摘要:
目的 探讨可溶性CD44V6(sCD44V6)、血清肿瘤标志物癌胚抗原(CEA)、非小细胞肺癌相关抗原细胞角蛋白19(CYFRA21-1)、糖链抗原199(CA199)、神经原特异烯醇化酶(NSE)和糖链抗原(CA125)联合检测在诊断恶性胸腹腔积液中的应用价值。方法 选择2015 ~ 2018 年结核性胸腹腔积液93 例,炎性胸腹腔积液44 例, 肝硬化腹腔积液39 例,共176 例(良性胸腹腔积液组),恶性肿瘤患者157 例(恶性胸腹腔积液组),应用酶联免疫吸附试验(ELISA)通过标准品绘制标准曲线检测sCD44V6 的浓度,采用化学发光法检测胸腹腔积液中CEA,CA199,CA125,CYFRA21-1 和NSE 水平,绘制ROC 曲线并计算曲线下面积(area under curve,AUC)来评价各指标的诊断价值。结果 恶性胸腹腔积液中sCD44V6,CEA,CA199,CYFRA21-1 和NSE 水平明显高于良性胸腹腔积液, 两者之间在统计学上有显著性差异(t=12.06 ~ 29.33, 均P<0.05)。恶性胸腹腔积液异常检出率高于良性胸腹腔积液组, 分别为81.53% vs 12.50%,67.28% vs 14.77%,55.41% vs 13.07%,94.90% vs 54.55%,79.62% vs 47.73%,64.33% vs 25.00%,差异均有统计学意义(χ2=36.11~159.73, 均P<0.05);ROC 曲线分析sCD44V6,CEA,CA199,CA125,CYFRA21-1,NSE 曲线下面积分别为0.816,0.755,0.719,0.784,0.735 和0.789,联合检测为0.958;各种检测项目单独检测评价以sCD44V6 最好,敏感度为79.61%,特异度为82.92%,联合检测指标敏感度为85.09%,特异度为93.58%。结论 sCD44V6,CEA,CA199,CA125,CYFRA21-1 和NSE 联合检测对胸腹腔积液良恶性鉴别诊断有重要价值。

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:刘涛(1986-),男,在职研究生,主管检验师,研究方向:分子与肿瘤,E-mail:15691688588@163.com。通讯作者:王剑锋,男, 副主任技师,E-mail:909616537@qq.com。收稿日期:2019-07-09修回日期:2020-01-16
更新日期/Last Update: 2020-04-30