[1]于彩霞,巩云霏,闫 苏,等.血清视黄醇结合蛋白4 及骨桥蛋白与绝经后骨质疏松症的相关性研究[J].现代检验医学杂志,2020,35(02):112-115.[doi:10.3969 / j.issn.1671-7414.2020.02.031]
 YU Cai-xia,GONG Yun-fei,YAN Su,et al.Relationship between Serum Retinol Binding Protein 4 and Osteopontin andPostmenopausal Osteoporosis[J].Journal of Modern Laboratory Medicine,2020,35(02):112-115.[doi:10.3969 / j.issn.1671-7414.2020.02.031]
点击复制

血清视黄醇结合蛋白4 及骨桥蛋白与绝经后骨质疏松症的相关性研究()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
112-115
栏目:
检验与临床
出版日期:
2020-05-24

文章信息/Info

Title:
Relationship between Serum Retinol Binding Protein 4 and Osteopontin andPostmenopausal Osteoporosis
文章编号:
1671-7414(2020)02-112-05
作者:
于彩霞巩云霏闫 苏孙国宗赵江彦王会芳
(涿州市医院检验科,河北涿州 072750)
Author(s):
YU Cai-xia GONG Yun-fei YAN Su SUN Guo-zong ZHAO Jiang-yan WANG Hui-fang
(Department of Clinical Laboratory, Zhuozhou Hospital, Hebei Zhuozhou 072750, China)
关键词:
绝经后骨质疏松症视黄醇结合蛋白4骨桥蛋白骨密度
分类号:
R591.1;R446.11
DOI:
10.3969 / j.issn.1671-7414.2020.02.031
文献标志码:
A
摘要:
目的 探讨绝经后妇女血清视黄醇结合蛋白4(retinol binding protein 4,RBP4)及骨桥蛋白(osteopontin,OPN) 水平与骨密度(bone mineral density,BMD) 的关系, 分析其在绝经后骨质疏松症(postmenopousalosteoporosis,PMOP)中的应用价值。方法 对262 例绝经后妇女进行研究双能X 线骨密度仪测量腰椎1-4(L1-4)和左侧股骨颈(FN),测定血中RBP4,OPN,I 型原胶原N- 端前肽(PINP),β- 胶原降解产物(β-CTX),甲状旁腺素(PTH),骨钙素(OC),血钙(Ca)及血磷(P)水平。ROC 曲线分析RBP4 及OPN 诊断PMOP 的价值。结果 骨质疏松组血清 RBP4(μg/ml)(25.13±4.74 , 18.46±4.25 和15.30±3.87)及OPN(ng/ml)(13.58±4.42 , 10.47±3.46 和8.24±3.13)水平均明显高于骨量减少组和正常组,差异有统计学意义(均P < 0.05)。相关分析显示,骨质疏松症组血清RBP4及OPN 水平与β-CTX 呈正相关(r=0.291,0.284,均P < 0.05),与Ca,L1-4 及左FN 骨密度呈负相关(r = - 0.247,-0.513,-0.486,-0.265,-0.556,-0.574,均P < 0.05)。ROC 曲线显示,血清RBP4 及OPN 水平为21.53μg/ml 和12.27 ng/ml 是诊断PMOP 的最佳截值。结论 血清RBP4 及OPN 水平升高与低BMD 相关,是影响PMOP 发生的关键因子。

参考文献/References:

[1] RAN S Y, YU Q, CHEN Y, et al. Prevention ofpostmenopausal osteoporosis in Chinese women: a5-year, double-blind, randomized, parallel placebocontrolledstudy[J]. Climacteric, 2017, 20(4): 391-396.
[2] FRANIC D, VERDENIK I. Risk factors for osteoporosisin postmenopausal women -from the point of view ofprimary care gynecologist[J]. Zdr Varst, 2018, 57(1):33-38.
[3] HATFIELD J T, ANDERSON P J, POWELL B C.Retinol-binding protein 4 is expressed in chondrocytesof developing mouse long bones: implications for alocal role in formation of the secondary ossificationcenter[J]. Histochem Cell Biol, 2013, 139(5): 727-734.
[4] TARQUINI C, MATTERA R, MASTRANGELI F,et al. Comparison of tissue transglutaminase 2 andbone biological markers osteocalcin, osteopontinand sclerostin expression in human osteoporosis andosteoarthritis[J]. Amino Acids, 2017, 49(3): 683-693.
[5] FASSHAUER M, BL-HER M. Adipokines in health anddisease[J]. Trends in Pharmacological Sciences, 2015,36(7): 461-470.
[6] NAGAO M, FEINSTEIN T N, EZURA Y, et al.Sympathetic control of bone mass regulated byosteopontin[J]. Proc Natl Acad Sci U S A, 2011,108(43): 17767-17772.   
[7] CHO E H, CHO K H, LEE H A, et al. High serumosteopontin levels are associated with low bone mineraldensity in postmenopausal women[J]. J Korean MedSci, 2013,28(10):1496-1499.
[8] 谭昱, 肖育志, 马春涛, 等. 绝经后妇女血清骨桥蛋白浓度与腰椎骨量丢失程度的相关性[J]. 广东医学,2015, 36(15): 2401-2403.   TAN Yu, XIAO Yuzhi, MA Chuntao, et al. Thecorrelation between serum osteopontin concentrationand the degree of lumbar vertebral bone loss inpostmenopausal women [J].Guangdong MedicalJournal, 2015, 36(15): 2401-2403.
[9] HUANG Nana, ZHOU Jin, WANG Wei, et al. Retinolbindingprotein 4 is positively associated with bonemineral density in patients with type 2 diabetes andosteopenia or osteoporosis[J]. Clin Endocrinol (Oxf),2018, 88(5): 659-664.
[10] 陈思敏, 邓伟民, 魏秋实, 等. 绝经后妇女血清 OPN水平与骨密度及骨转换水平的 相关性研究[J]. 中国骨质疏松杂志, 2014,20 (12): 1393-1397.   CHEN Simin, DENG Weimin, WEI Qiushi, etal. Relation between serum osteopontin level andbone mineral density and bone turnover markersin postmenopausal women [J]. Chinese Journal ofOsteoporosis, 2014, 20(12): 1393-1397.
[11] CHANG I C, CHIANG T I, YEH K T, et al. Increasedserum osteopontin is a risk factor for osteoporosis inmenopausal women [J]. Osteoporos Int, 2010, 21(8):1401-1409.
[12] FODOR D, BONDOR C, ALBU A, et al. The value ofosteopontin in the assessment of bone mineral densitystatus in postmenopausal women [J]. J Investig Med,2013, 61(1): 15-21.
[13] WEI Qiushi, HUANG Li, TAN Xin, et al. Serumosteopontin levels in relation to bone mineral densityand bone turnover markers in postmenopausalwomen[J]. Scandinavian Journal of Clinical andLaboratory Investigation, 2016, 76(1): 33-39.

相似文献/References:

[1]孟 俊a,顾志冬a,陈呢喃b,等.视黄醇结合蛋白4检测在营养性疾病 及肝肾损害检测中的临床应用[J].现代检验医学杂志,2015,30(01):1.[doi:10.3969/j.issn.1671-7414.2015.01.001]
 MENG Juna,GU Zhi-donga,CHEN Ninanb,et al.Assessment of Retinol Binding Protein 4 in Nutritional Diseases and Liver or Kidney Diseases[J].Journal of Modern Laboratory Medicine,2015,30(02):1.[doi:10.3969/j.issn.1671-7414.2015.01.001]
[2]黄燕红a,黄丽玲b,雷美红a,等.绝经后骨质疏松症患者血清几丁质酶壳三糖苷酶、血管活性肠肽水平与骨密度及骨代谢标志物的相关性研究[J].现代检验医学杂志,2022,37(02):179.[doi:10.3969/j.issn.1671-7414.2022.02.036]
 HUANG Yan-honga,HUANG Li-lingb,LEI Mei-honga,et al.Correlation between Serum Levels of Chitotriosidase1, Vasoactive Intestinal Peptide and Bone Mineral Density and Bone Turnover Indicators in Postmenopausal Osteoporosis Patients[J].Journal of Modern Laboratory Medicine,2022,37(02):179.[doi:10.3969/j.issn.1671-7414.2022.02.036]
[3]张恒林,吴克第,王声威,等.绝经后骨质疏松症患者血清CCL2,CX3CL1 和CXCL10 的水平表达及对骨折发生的预测价值[J].现代检验医学杂志,2024,39(04):165.[doi:10.3969/j.issn.1671-7414.2024.04.030]
 ZHANG Henglin,WU Kedi,WANG Shengwei,et al.Expression Levels of Serum CCL2, CX3CL1 and CXCL10 in Postmenopausal Osteoporosis Patients and Their Predictive Value for Fracture Occurrence[J].Journal of Modern Laboratory Medicine,2024,39(02):165.[doi:10.3969/j.issn.1671-7414.2024.04.030]

备注/Memo

备注/Memo:
基金项目:保定市科学计划与发展指导计划项目(16ZF025)。作者简介:于彩霞(1981-),女,本科,副主任技师, 研究方向:主要从事临床骨代谢疾病检验诊断研究。E-mail:caixiaer0366@163.com。通讯作者:王会芳,E-mail:592324720@qq.com。收稿日期:2019-05-07 修回日期:2019-12-02
更新日期/Last Update: 2020-04-30