[1]吴剑锋.男性基础性激素水平与精子质量参数的相关性探讨[J].现代检验医学杂志,2020,35(03):69-71.[doi:10.3969/j.issn.1671-7414.2020.03.017]
 WU Jian-feng.Correlation between Male Basic Sex Hormones and Sperm Quality Parameters[J].Journal of Modern Laboratory Medicine,2020,35(03):69-71.[doi:10.3969/j.issn.1671-7414.2020.03.017]
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男性基础性激素水平与精子质量参数的相关性探讨()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年03期
页码:
69-71
栏目:
论著
出版日期:
2020-07-20

文章信息/Info

Title:
Correlation between Male Basic Sex Hormones and Sperm Quality Parameters
文章编号:
1671-7414(2020)03-069-04
作者:
吴剑锋
( 佛山市南海区妇幼保健院检验科,广东佛山 528200)
Author(s):
WU Jian-feng
(Department of Clinical Laborator y,Nanhai Maternity and Child Healthcar e Hospital of Foshan, Guangdong Foshan 528200,China)
关键词:
男性卵泡刺激素黄体生成素催乳素雌二醇睾酮精子质量
分类号:
R446.19
DOI:
10.3969/j.issn.1671-7414.2020.03.017
摘要:
目的 分析男性基础性激素包括卵泡刺激素(FSH)、黄体生成素(LH)、催乳素(PRL)、雌二醇(E2)、 睾酮(T)与精子质量参数的关系,探讨性激素检测在男性不育症的诊断价值。方法 选取2018 年6 月~2019 年6 月 在生殖健康科就诊患者350 例,根据精液检查结果分为少精子组(n=103)、无精子组(n=26)和弱精子组(n=121) 作为实验组,精子正常组(n=100)作为对照组,比较各组的性激素水平是否存在差异,并与精子质量参数进行相 关性分析。结果 与对照组比较,少精子组的FSH,LH 和PRL 水平升高,E2 和T 水平降低,差异均有统计学意义 (t=2.42~2.53,均P<0.05);弱精子组的LH 和PRL 水平升高,E2 水平降低,差异均有统计学意义(t =2.06 ~ 2.34, 均P<0.05);无精子组的FSH,LH 和PRL 水平明显升高,E2 和T 水平明显降低,差异均有统计学意义(t=3.78 ~ 14.39, 均P<0.01)。FSH 与精子密度、精子活率、精子总活力呈负相关(r =- 0.24, - 0.19, - 0.34, 均P<0.05);LH 与精子密度、 精子活率、精子总活力呈负相关(r = - 0.20, - 0.21, - 0.28, 均P<0.05);E2 与精子密度和精子总活力呈正相关(r= 0.19, 0.14,均P<0.05);T 与精子密度和正常形态精子率呈正相关(r = 0.15, 0.14, 均P<0.05)。结论 男性基础性激素与精 子质量参数存在一定的相关性,对男性生育评估、不育症的诊断和治疗有重要意义。
Abstract:
Objective To analyze the relationship between basic sex hormones including follicle stimulating hormone(FSH), luteinizing hormone (LH),prolactin (PRL),estradiol (E2),testosterone (T) and sperm quality parameters, and explore the diagnostic value of sex hormone detection in male infertility. Methods From June 2018 to June 2019, 350 patients in reproductive health department were divided into oligospermia group (n=103),azoospermia group (n=26) and asthenospermia group (n=121) as the experimental group, and normal sperm group (n=100) as the control group. The differences of sex hormone levels in each group were compared and the correlation between them and sperm quality parameters was analyzed. Results Compared with the control group, the FSH, LH and PRL levels of oligospermia group increased, the E2 and T levels decreased, and the difference was statistically significant (t= 2.42~2.53, all P < 0.05). The LH and PRL levels of oligospermia group increased, the E2 level decreased, and the difference was statistically significant (t = 2.06~2.34, all P < 0.05). The FSH, LH and PRL levels of azoospermia group increased, the E2 and T levels decreased, and the difference was statistically significant (t = 3.78~14.39, P < 0.01). FSH was negatively correlated with sperm density, sperm viability and total sperm motility (r = - 0.24, - 0.19, - 0.34, all P < 0.05). LH was negatively correlated with sperm density, sperm viability and total sperm motility (r = - 0.20, - 0.21, - 0.28, all P<0.05). E2 was positively correlated with sperm density and total sperm motility (r = 0.19, 0.14, all P < 0.05), and T was positively correlated with sperm density and normal sperm motility (r = 0.15, 0.14, all P<0.05), and . Conclusion There was a certain correlation between basic sex hormones and sperm quality parameters,which is of great significance for male fertility assessment,diagnosis and treatment of infertility.

参考文献/References:

[1]  苏京荣,李琳.1 226 例男性不育患者的细胞遗传学 分析[J].中华医学遗传学杂志,2016,33(2): 266-268.    SU Jingrong, LI Lin. Cytogenetic analysis of 1 226 cases of male infertility[J]. Chinese Journal of Medical Genetics, 2016,33(2):266-268.
[2] 孙宝刚,管福来,曹井贺,等.特发性少、弱精子 症患者精液质量指标及辅助生殖妊娠结局相关性研 究[J].中国男科学杂志,2018,32(2):36-40.   SUN Baogang ,GUAN Fulai,CAO Jinghe, et al. Correlative analysis of semen quality of idiopathic oligospermia and asthenospermia patients and the outcome of ART treatment [J]. Chinese Journal of Andrology, 2018,32(2):36-40.
[3] 世界卫生组织.人类精液检查与处理实验室手册 [M].5 版. 北京:人民卫生出版社,2011.    World Health Organization. Manual of human semen examination and processing laboratory[M]. 5th Ed. Beijing: People's Medical Publishing House,2011.
[4] 赵骥腾,岳长久,陈佳.无精子症患者睾丸穿刺活 检与血清 LH,FSH 水平的相关性[J].中华内分泌外 科杂志,2016,10(1):67-70.    ZHAO Jiteng,YUE Changjiu,CHEN Jia. Relationship between testicular biopsy and serum levels of LH and FSH in patients with azoospermia[J].Chinese Journal of Endocrine Surgery, 2016,10(1):67-70.
[5] COMAR V A, PETERSEN C G, MAURI A L, et al. Influence of the abstinence period on human sperm quality: analysis of 2 458 semen sanples[J]. JBRA Assist Reprod, 2017, 21(4): 306-312.
[6] DOSTALOVA P, ZATECKA E, DVORAKOVAHORTOVA K. Of oestrogens and sperm: A review of the roles of oestrogens and oestrogen receptors in male reproduction[J]. International Journal of Molecular Sciences, 2017, 18(5): 1-23.
[7]  程国隆,宋荣.男性无精子症患者血清生殖激素水 平与睾丸生精功能的相关性分析[J].中国当代医药, 2017,24(10):36-38.   CHENG Guolong,SONG Rong. Correlation analysis of serum reproductive hormone levels and testicular spermatogenic fhnction of male patients with azoospermia [J].China Modern Medicine,2017, 24(10):36-38.
[8]  朱红芬,齐涵沁,朱航.无精子症患者外周血染色 体核型和生殖激素水平分析[J].中国优生与遗传杂 志,2017,25(2):62-63,33.   ZHU Hongfen,QI Hanqin,ZHU Hang. No sperm in patients with peripheral blood chromosome karyotype and reproductive hormone level analysis[J].Chinese Journal of Birth Health & Heredity, 2017,25 (2):62-63,33.
[9]  宋明哲,叶丽君,尹彪,等.精浆和血清生殖激素 与精液质量的关系[J].生殖医学杂志,2016,25(4): 341-346.   SONG Mingzhe,YE Lijun,YIN Biao,et al. Relationship between reproductive hormone in semen or seminal plasma and serum quality[J]. Journal of Reproductive Medicine,2016,25(4) :341-346.
[10] 白双勇,王莉,章晓梅,等.雌二醇与男性精液质量 关系研究[J].云南医药,2018,39(3):196-199.   BAI Shuangyong,WANG Li,ZHANG Xiaomei,et al. Correlation between anti-mullerian hormonein serum and sex hormone sperm parameters [J]. Medicine and Pharmacy of Yunnan, 2018,39(3):196-199.
[11] CORREIA S, CARDOSO H J, CAVACO J E,et al. Oestrogens as apoptosis regulators in mammaliantestis: angels or devils [J]. Expert Rev Mol Med, 2015 ,17:e2.
[12] 文春蓉,杨鹏.男性不育患者精液常规参数与生殖 激素的关系[J].现代医药卫生,2016,32(13): 1989-1990,1993.   WEN Chunrong,YANG Peng. Relationship between semen routine parameters with reproductive hormones in male infertility patients[J].Journal of Modern Medicine & Health,2016,32(13),1989-1990,1993.
[13] SAAD F, DOROS G, HAIDER K S, et al. Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms[J]. Investigative and Clinical Urology, 2018, 59(6): 399-409.

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备注/Memo

备注/Memo:
收稿日期:2020-01-02 修回日期:2020-01-16作者简介:吴剑锋(1984-),男,大学本科,主管技师,主要从事临检、免疫方面工作,E-mail:9093361@qq.com。
更新日期/Last Update: 2020-07-20