[1]孔丽蕊,黄　英,张　艳,等.血糖、糖化血红蛋白的参考变化值和参考变化因子的应用研究[J].现代检验医学杂志,2020,35(03):110-111.[doi:10.3969/j.issn.1671-7414.2020.03.029]
　KONG Li-rui,HUANG Ying,ZHANG Yan,et al.Application Study of Reference Change Value and Reference Change Factor of Blood Glucose and Glycated Hemoglobin[J].Journal of Modern Laboratory Medicine,2020,35(03):110-111.[doi:10.3969/j.issn.1671-7414.2020.03.029]
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血糖、糖化血红蛋白的参考变化值和参考变化因子的应用研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年03期
页码:
110-111
栏目:
研究简报·实验技术
出版日期:
2020-07-20

文章信息/Info

Title:
Application Study of Reference Change Value and Reference Change Factor of Blood Glucose and Glycated Hemoglobin
文章编号:
1671-7414（2020）03-110-03
作者:
孔丽蕊; 黄　英; 张　艳; 徐晓华; 罗　宇; 潘跃承; 刘　翔
（成都市郫都区中医医院检验科，成都　611730）
Author(s):
KONG Li-rui;  HUANG Ying;  ZHANG Yan;  XU Xiao-hua;  LUO Yu;  PAN Yue-cheng;  LIU Xiang
（Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of Pidu District, Chengdu 611730, China）
关键词:
参考变化值; 参考变化因子; 血糖; 糖化血红蛋白
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2020.03.029
摘要:
目的　探讨血糖(GLU)、糖化血红蛋白（HbA1c）的参考变化值（reference change value， RCV） 和参考变化 因子(reference change factor, RCF）在临床的应用。方法　根据RCV 计算公式：RCV=Z×21/2×( CV2 A + CVI 2 )1/2 和RCF 上、下限计算公式：RCFup=exp（Z×21/2×( CV2 A + CVI 2 )1/2/100）以及RCFdown=1/RCFup，分别计算GLU，HbA1c 的RCV 和RCF 在不同概率P<0.05，P<0.01 时单双侧值。结果　RCV 在P<0.05 时单双侧值分别为GLU（13.50%，16.04%）和 HbA1c (6.03%，7.16%)；在P<0.01 时单双侧值分别为GLU(19.07%，21.12%) 和HbA1c(8.51%，9.42%)。RCF 在P<0.05 时单双侧的RCFup 和RCFdown 分别为GLU(1.14，0.87；1.17，0.85) 和HbA1c(1.06，0.94；1.07，0.93)；P<0.01 时，RCF 单双侧的RCFup 和RCFdown 分别为GLU(1.21，0.83；1.24，0.81) 和HbA1c(1.09，0.92；1.10，0.91)。结论　RCV 在相同 概率下双侧值大于单侧值；P<0.05 的RCV 值小于P<0.01 的RCV 值。RCF 在相同概率下，单侧和双侧RCF 的上、下 限值变化不大；P<0.05 的RCF 上、下限值大于P<0.01 的RCF 上、下限值。建议临床实验室在监测糖尿病患者GLU， HbA1c 指标时，结合RCV 和RCF 判读检测结果。
Abstract:
Objective　To investigate the clinical application of reference change value (RCV) and reference change factor (RCF) for blood glucose (GLU) and glycated hemoglobin (HbA1c). Methods　According to RCV calculation formula: RCV = Z×21/2×( CV2 A + CVI 2 )1/2 and RCF upper and lower limit calculation formula: RCFup = exp (Z×21/2×( CV2 A + CVI 2 )1/2/100) and RCFdown = 1 / RCFup. Single and double-sided values of RCV and RCF of GLU and HbA1c were calculated respectively at different probability P <0.05, P <0.01. Results　When P <0.05, the unilateral and bilateral values of RCV were GLU (13.50%, 16.04%) and HbAIc (6.03%, 7.16%). When P <0.01, the unilateral and bilateral values of RCV were GLU (19.07%, 21.12%) and HbA1c (8.51%, 9.42%).When P<0.05, the RCFup and RCFdown values of unilateral and bilateral RCF were GLU(1.14, 0.87 and 1.17, 0.85), HbAIc(1.06, 0.94 and 1.07, 0.93). When P<0.01, the RCFup and RCFdown values of unilateral and bilateral RCF were GLU(1.21, 0.83;1.24, 0.81), HbA1c(1.09, 0.92 and 1.10, 0.91). Conclusion　The bilateral value of RCV was greater than the unilateral value under the same probability. The value of RCV at P<0.05 was less than its value at P <0.05.Under the same probability, the upper and lower limits of one and two sides of RCF dose not change much. The upper and lower limits of RCF with P<0.05 were greater than those with P<0.01. It was suggested that the clinical laboratory should combine RCV and RCF to interpret the test results when monitoring GLU and HBA1C indicators in diabetic patients.

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备注/Memo

备注/Memo:
收稿日期：2019-08-10 修回日期：2020-02-13作者简介：孔丽蕊(1972-)，女，本科，副主任技师，研究方向：临床生物化学和免疫学，E-mail:524392472@qq.com
更新日期/Last Update: 2020-07-20