[1]周　勃.天津铁路健康体检员工血清胃蛋白酶原水平调查研究[J].现代检验医学杂志,2020,35(03):138-140.[doi:10.3969/j.issn.1671-7414.2020.03.037]
　ZHOU Bo.Investigation and Study on Serum Pepsinogen Levels in Physical Examination Staff of Tianjin Railway[J].Journal of Modern Laboratory Medicine,2020,35(03):138-140.[doi:10.3969/j.issn.1671-7414.2020.03.037]
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天津铁路健康体检员工血清胃蛋白酶原水平调查研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年03期
页码:
138-140
栏目:
检验与临床
出版日期:
2020-07-20

文章信息/Info

Title:
Investigation and Study on Serum Pepsinogen Levels in Physical Examination Staff of Tianjin Railway
文章编号:
1671-7414（2020）03-138-04
作者:
周　勃
（中国铁路北京局集团有限公司天津铁路疾病预防控制中心，天津　300140）
Author(s):
ZHOU Bo
(Tianjin Railway Centers for Disease Control and Prevention of Beijing Railway Bureau，Tianjin 300140,China)
关键词:
健康体检; 铁路员工; 胃蛋白酶原; 酶联免疫吸附试验
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2020.03.037
摘要:
目的　调查天津铁路健康体检员工的血清胃蛋白酶原（PG）水平, 探讨其变化规律。方法　选取2019 年3 月~11 月于天津铁路疾病预防控制中心进行健康体检的铁路员工49 523 例，采用酶联免疫吸附法检测其血清胃蛋白酶 原Ⅰ（PG Ⅰ），胃蛋白酶原Ⅱ（PG Ⅱ）的水平并计算PG Ⅰ /PG Ⅱ比值（PGR），应用spss19.0 统计软件分析比较 不同性别、不同年龄（＜ 31 岁，31 ～ 40 岁，41 ～ 50 岁和＞ 50 岁），不同工种间铁路员工PG 的差异。结果　铁路 员工血清PG Ⅰ，PG Ⅱ和PGR 水平M（P25，P75）分别为 81.72（67.31,97.08）ng/ml，7.6（4.98,11.82）ng/ml 和 10.55 （7.05,15.52）。男性组PG Ⅰ，PG Ⅱ和PGR 水平M（P25，P75）分别为82.66（68.24,97.95）ng/ml，7.82（5.19,12.01） ng/ml 和10.36（6.97,15.14），女性组分别为74.19（60.94,88.96）ng/ml，5.64（3.70,9.82）ng/ml 和12.71（7.96,18.45）， 差异均有统计学意义（U=90 670 471.00 ~139 064 629.00，P=0.000）。不同年龄组间血清 PG 的水平差异均有统计学意 义（H=1 269.02～ 3 779.45，P=0.000）。随着年龄的增高，血清 PG Ⅰ，PG Ⅱ水平升高和PGR 降低。比较不同工种间 血清 PG 的水平差异，一线员工PG Ⅰ水平要高于附属员工，差异有统计学意义（U=65 095 021.50，P=0.000）；PG Ⅱ 和PGR 水平的差异无统计学意义（U=68 566 462.50，67 380 108.50，P=0.731，0.055）。相关性分析结果显示，PG Ⅰ 和PG Ⅱ水平与年龄呈正相关（rs ＝ 0.161，0.284，P ＜ 0.05）；PGR 与年龄呈负相关（rs ＝－ 0.234，P ＜ 0.05）。结 论　天津铁路疾病预防控制中心健康体检员工血清PG Ⅰ，PG Ⅱ和PGR 水平呈明显的偏态分布，在不同性别、不同年 龄组间其差异有统计学意义，而不同工种间的差异需进一步研究。
Abstract:
Objective　To investigate the serum pepsinogen(PG) levels in Tianjin Railway staff for physical examination and study the variable rules. Methods　4 9523 railway staff were selected from March to November 2019 for physical examination in Center for Disease Control and Prevention of Tianjin Railway. The levels of serum pepsinogen Ⅰ (PGⅠ) and pepsinogen Ⅱ (PG Ⅱ )were detected by enzyme-linked immunosorbent assay (ELISA), and the ratio of PG Ⅰ to PG Ⅱ (PGR) was calculated. The differences were compared between different genders, among different age groups(< 31,31~40,41~50 and ＞ 50) and different types of worker groups by SPSS19.0 statistical software. Results　The M（P25，P75）of serum PG Ⅰ , PG Ⅱ and PGR among railway staff were 81.72(67.31,97.08)ng/ml, 7.6(4.98,11.82) ng/ml and 10.55 (7.05,15.52) respectively. The levels of PG Ⅰ , PG Ⅱ and PGR in male group were 82.66 (68.24,97.95)ng/ml,7.82(5.19,12.01)ng/ml and 10.36(6.97,15.14) respectively,which in female group were 74.19(60.94, 88.96)ng/ml,5.64(3.70,9.82)ng/ml and 12.71(7.96,18.45).There were significant differences between two gender groups（U=90 670 471.00 ～ 139 064 629.00，P=0.000）and among different age groups（H=1 269.02 ～ 3 779.45，P=0.000）. With the ages increasing, the levels of serum PG Ⅰ and PG Ⅱ increased, while PGR decreased. The level of serum PG Ⅰ in the front-line workers was higher than that in the affiliated workers（U=65095021.50， P=0.000）, while there were no significant differences in the levels of PG Ⅱ and PGR（U=68 566 462.50，67 380 108.50， P=0.731，0.055). The results of correlation analysis showed that the PG Ⅰ and PG Ⅱ were positively correlated with age (rs=0.161, 0.284, P< 0.05), and PGR was negatively correlated with age (rs=-0.234, P< 0.05). Conclusion　The levels of serum PG Ⅰ ,PG Ⅱ and PGR in Railway staff for physical examination of Tianjin Railway Centers for Disease Control and Prevention showed obviously skewed distribution with significant differences between genders, among age groups.The differences between two types of work groups need further research .

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备注/Memo

备注/Memo:
收稿日期：2020-01-15 修回日期：2020-03-11作者简介：周勃(1982-)，男，硕士，副主任技师，主要从事临床免疫和健康管理工作，E-mail:110199249@qq.com
更新日期/Last Update: 2020-07-20