[1]汪学耀,张涛,荆成宝.血清总胆汁酸与甘胆酸水平诊断妊娠期肝内胆汁淤积症能力的Meta 分析[J].现代检验医学杂志,2020,35(05):73-76.[doi:10.3969/j.issn.1671-7414.2020.05.019]
　WANG Xue-yao,ZHANG Tao,JING Cheng-bao.Meta Analysis of the Ability of Total Bile Acid and Cholyglycine to Diagnose Intrahepatic Cholestasis of Pregnancy[J].Journal of Modern Laboratory Medicine,2020,35(05):73-76.[doi:10.3969/j.issn.1671-7414.2020.05.019]
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血清总胆汁酸与甘胆酸水平诊断妊娠期肝内胆汁淤积症能力的Meta 分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
73-76
栏目:
论著
出版日期:
2020-11-01

文章信息/Info

Title:
Meta Analysis of the Ability of Total Bile Acid and Cholyglycine to Diagnose Intrahepatic Cholestasis of Pregnancy
文章编号:
1671-7414（2020）05-073-04
作者:
汪学耀1; 张涛2; 荆成宝2
1. 安康市汉滨区第三人民医院，陕西安康 725000；2. 安康市中心医院，陕西安康 725000
Author(s):
WANG Xue-yao1;  ZHANG Tao2;  JING Cheng-bao2
1.the Third People’s Hospital of Hanbin District,Shaanxi Ankang 725018, China; 2. Ankang Central Hospital, Shaanxi Ankang 725000,China
关键词:
总胆汁酸; 甘胆酸; 妊娠期肝内胆汁淤积症
分类号:
R714.255；R446.112
DOI:
10.3969/j.issn.1671-7414.2020.05.019
文献标志码:
A
摘要:
目的　评估总胆汁酸（total bile acid，TBA）与甘胆酸（cholylglycine，CG）对妊娠期肝内胆汁淤积症（intrahepatic cholestasia of pregnany, ICP）的诊断能力。方法　检索PubMed，Embase，Cochrane，CNKI，维普和万方数据库自 建库至2020 年2 月的相关文献，纳入符合标准的文献；运用诊断精确性研究的质量鉴定标准（quality assessment of diagnostic accuracy studies-2, QUADAS-2）进行文献质量评价；计算灵敏度、特异度及受试者工作特征曲线下面积（area under the cure，AUC），判断总胆汁酸与甘胆酸的诊断能力。结果　共纳入8 项研究总胆汁酸、甘胆酸诊断妊娠期肝内 胆汁淤积症的灵敏度分别为 0.81(95%CI：0.72~0.88) 和0.93(95%CI：0.9~0.95)；特异度依次为0.93(95%CI：0.87~0.97) 和0.97(95%CI：0.91~0.99)；AUC 分别为0.93（95%CI：0.90~0.95) 和0.96（95%CI：0.94~0.98)。结论　总胆汁酸和甘 胆酸均是诊断妊娠期肝内胆汁淤积症的有效指标，且甘胆酸的诊断能力高于总胆汁酸。
Abstract:
Objective　To evaluate the diagnostic ability of total bile acid(TBA) and cholyglycine(CG) in intrahepatic cholestasis of pregnancy(ICP). Methods　PubMed, Embase, Cochrane, CNKI, VIP and Wanfang databases were searched until February 2020 for relevant literatures, and literatures meeting the criteria were included. Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used for literature quality evaluation. The sensitivity, specificity and Area Under the Cure (AUC) were calculated to determine the diagnostic ability of TBA and CG. Results　A total of eight studies were included in this analysis. The sensitivity of TBA and CG in the diagnosis of ICP were 0.81 (95% CI: 0.72 ~ 0.88) and 0.93 (95% CI: 0.9 ~ 0.95), the specificity were 0.93 (95% CI: 0.87 ~ 0.97) and 0.97 (95% CI: 0.91 ~ 0.99), and the AUC were 0.93 (95% CI: 0.90 ~ 0.95) and 0.96 (95% CI: 0.94 ~ 0.98), respectively. Conclusion 　Both TBA and CG are effective indicators for the diagnosis of ICP and the diagnostic ability of CG is higher than that of TBA.

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备注/Memo

备注/Memo:
作者简介：汪学耀（1980-），男，在读研究生，副主任检验技师，主要从事细胞形态学研究。
通讯作者：荆成宝，E-mail：jykjcb@126.com。
更新日期/Last Update: 2020-10-30