[1]白欢,沈玲,袁旭,等.新型冠状病毒肺炎患者早期外周血实验室检查结果分析[J].现代检验医学杂志,2020,35(05):93-98.[doi:10.3969/j.issn.1671-7414.2020.05.024]
　BAI Huan,SHEN Ling,YUAN Xu,et al.Analysis of the Characteristics of Hematological Parameters in the Early Stages of COVID-19[J].Journal of Modern Laboratory Medicine,2020,35(05):93-98.[doi:10.3969/j.issn.1671-7414.2020.05.024]
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新型冠状病毒肺炎患者早期外周血实验室检查结果分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
93-98
栏目:
新型冠状病毒肺炎检验专题
出版日期:
2020-11-01

文章信息/Info

Title:
Analysis of the Characteristics of Hematological Parameters in the Early Stages of COVID-19
文章编号:
1671-7414（2020）05-093-06
作者:
白欢; 沈玲; 袁旭; 王旭; 唐宁
华中科技大学同济医学院附属同济医院检验科，武汉 430030
Author(s):
BAI Huan; SHEN Ling ; YUAN Xu ;  WANG Xu; TANG Ning
Department of Clinical Laboratory, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
关键词:
新型冠状病毒肺炎; 早期诊断; 超敏C 反应蛋白; 低钙血症
分类号:
R373.19；R446.11
DOI:
10.3969/j.issn.1671-7414.2020.05.024
文献标志码:
A
摘要:
目的　分析新型冠状病毒肺炎（corona virus disease 2019,COVID-19）患者早期外周血实验室检查结果特征， 为临床早期识别提供参考。方法　选取2020 年1 月11 日至2020 年2 月18 日所有在华中科技大学同济医学院附属同 济医院发热门诊就诊且新型冠状病毒(SARS-CoV-2) 核酸检测阳性的626 例患者作为研究组，另选取同期就诊发热门诊且 SARS-CoV-2 核酸检测连续两次或两次以上阴性的254 例疑似患者作为对照组，分析两组患者首次就诊发热门诊时血细胞 检测、生化常规、炎症标志物等31 项血液学指标的特征。结果　较对照组相比，研究组白细胞(white blood cell,WBC)、 淋巴细胞(lymphocyte, LYMPH)、血小板(platelet,PLT)、血清钙(serum calcium,Ca) 显著降低，超敏C 反应蛋白(hypersensitive C-reactive protein,hsCRP) 显著升高， 差异具有统计学意义(U= 72 655，62 369.5，63 573，t=2.944，U=37 014.5， 均 P<0.05)，且在结果分布上差异亦具有统计学意义。研究组WBC 多正常或降低，WBC 正常者占比85.3%，降低者占比 9.4%，LYMPH 降低者占比43.1%，PLT 降低者占比12.8%，Ca 降低者占比61.8%，hsCRP 高于10mg/L 者占比66.2%( χ ２ =12.792，9.523，11.222，7.562 和36.316, 均P<0.01)。余26 项血液学指标(Cl，Na，K，HCO3，Urea，UA，Cr，TBA， CHE，ALB，ALT，ALP，LDH，TP，PCT，DBIL，GLB，IBIL，TBIL，γ-GGT，TCHOL，AST，Hb，RBC，NEUT， MON) 两组比较差异均无统计学意义( 均P>0.05)。结论　WBC，LYMPH，PLT，Ca 和hsCRP 在COVID-19 患者发病初期 即存在显著改变，联合检测并观察以上指标特征，可为临床早期识别提供重要参考。
Abstract:
Objective　To analyze the characteristics of hematological parameters in the early stages of COVID-19, for the purpose of providing some reference values for the early recognition of COVID-19. Methods　Retrospectively enrolled 626 outpatients admitted to the Fever Clinic of Tongji Hospital of Huazhong University of Science and Technology in Wuhan from January 11 to February 18, 2020, with the positive results of SARS-CoV-2 nucleic acid, were treated as reseach group. In addition, 254 outpatients admitted to the Fever Clinic at the same period, with at least two consecutive negative results of SARSCoV- 2 nucleic acid were enrolled, and treated as control group. The results of 31 hematological parameters, such as routine blood testing, routine biochemical testing and inflammatory biomarkers were collected and compared. Results　Compared with the results of control group, in reseach group, white blood cell(WBC), lymphocyte(LYMPH), platelet(PLT), serum calcium(Ca) were significantly reduced, however, hypersensitive C-reactive protein(hsCRP) was significantly increased(U= 72 655, 62 369.5，63 573，t=2.944，U=37 014.5，all P<0.05). Furthermore, the composition ratio of abnormal results among WBC, LYMPH, PLT, Ca, hsCRP also had significant differences, in reseach group, WBC most were normal or reduced, normal WBC accounted for 85.3% , decreased WBC for 9.4% ,and decreased LYMPH accounted for 43.1% , decreased PLT for 12.8%, decreased Ca accounted for 61.8% , and hsCRP , which was higher than 10mg/L, accounted for 66.2%(χ2= 12.792, 9.523, 11.222, 7.562, 36.316, all P<0.01). The other 26 hematological parameters, such as Cl, Na, K, HCO3, Urea, UA, Cr, TBA, CHE, ALB, ALT, ALP, LDH, TP, PCT, DBIL, GLB, IBIL, TBIL, γ-GGT, TCHOL, AST, Hb, RBC, NEUT and MON, had no significant differences between two groups(all P>0.05). Conclusion　WBC, LYMPH, PLT, Ca and hsCRP had significant alters in the early stages of COVID-19. Combined detection and observation of these hematological parameters may provide important reference values for the early recognition of COVID-19.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金青年科学基金项目（编号：31600666）。
作者简介：白欢（1987-），男，主管技师，研究方向：临床检验诊断学，E-mail:huanzi1987_hust@163.com。
通讯作者：沈玲，E-mail：baobeisling@163.com。
更新日期/Last Update: 2020-10-30