[1]朱旭阳,叶寒青,陈文亥,等.新型冠状病毒肺炎患者血清SARS-CoV-2 抗体的检测分析[J].现代检验医学杂志,2020,35(04):106-108,164.[doi:10.3969/j.issn.1671-7414.2020.04.026]
 ZHU Xu-yang,YE Han-qing,CHEN Wen-hai,et al.Preliminary Analysis of Serum Antibodies Against SARS-CoV-2 in Patient with Coronavirus Disease 2019[J].Journal of Modern Laboratory Medicine,2020,35(04):106-108,164.[doi:10.3969/j.issn.1671-7414.2020.04.026]
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新型冠状病毒肺炎患者血清SARS-CoV-2 抗体的检测分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年04期
页码:
106-108,164
栏目:
新型冠状病毒肺炎检验专题
出版日期:
2020-09-05

文章信息/Info

Title:
Preliminary Analysis of Serum Antibodies Against SARS-CoV-2 in Patient with Coronavirus Disease 2019
文章编号:
1671-7414(2020)04-106-04
作者:
朱旭阳叶寒青陈文亥赵 行翁吉仁张艳敏
(温州医科大学附属乐清医院检验科,浙江乐清 325600)
Author(s):
ZHU Xu-yang YE Han-qing CHEN Wen-hai ZHAO Hang WENG Ji-ren ZHANG Yan-ming
(Department of Clinical Laboratory, Yueqing Hospital Affiliated to Wenzhou Medical University ,Zhejiang Yueqing 325600,China)
关键词:
新型冠状病毒肺炎新型冠状病毒免疫球蛋白M免疫球蛋白G
分类号:
R373.19;R446.62
DOI:
10.3969/j.issn.1671-7414.2020.04.026
文献标志码:
A
摘要:
目的 分析新型冠状病毒肺炎(corona virus disease 2019,COVID-19) 患者血清新型冠状病毒(severeacute respiratory syndrome coronavirus 2,SARS-CoV-2)IgM 和IgG 抗体的变化规律及临床应用。方法 收集2020 年1 ~ 2 月初温州医科大学附属乐清医院收治的28 例SARS-CoV-2 核酸检测阳性的COVID-19 患者作为病例组,排除COVID-19 的30 例其他疾病患者作为对照组。利用全自动化学发光免疫分析技术检测所有研究对象的血清SARS-CoV-2IgM 和IgG,分析SARS-CoV-2 抗体的变化规律。结果 SARS-CoV-2 IgM,发病第1 ~ 6 天均阴性,发病第7 ~ 10 天,2 例患者阳性,发病第18 天后均转阳性,一个月左右达峰值,2 例患者分别在第49 天和第55 天出现9.80AU/ml(阴性)和10.79AU/ml(弱阳性)。SARS-CoV-2 IgG,发病第1 ~ 6 天均阴性,发病第8 天后均阳性。结论 发病10 天内SARS-CoV-2 IgM 阴性的患者不能排除SARS-CoV-2 感染,发病超过一周或多次核酸检测阴性的疑似患者检测SARSCoV-2 IgM 和IgG 具有重要意义。

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备注/Memo

备注/Memo:
收稿日期:2020-05-29 修回日期:2020-06-21作者简介:朱旭阳(1973-),女,本科,副主任技师,专业:临床免疫学和分子生物学检验,E-mail:zhuxuyang007@163.com。
更新日期/Last Update: 2020-10-08