[1]孟凡萍,郝 坡.新型冠状病毒肺炎患者外周血淋巴细胞亚群的分析研究[J].现代检验医学杂志,2021,36(02):114-117.[doi:doi:10.3969/j.issn.1671-7414.2021.02.027]
 MENG Fan-ping,HAO Po.Analysis of Peripheral Blood Lymphocyte Subsets in Patients with Novel Coronavirus Pneumonia[J].Journal of Modern Laboratory Medicine,2021,36(02):114-117.[doi:doi:10.3969/j.issn.1671-7414.2021.02.027]
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新型冠状病毒肺炎患者外周血淋巴细胞亚群的分析研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
114-117
栏目:
新型冠状病毒肺炎检验专题
出版日期:
2021-04-30

文章信息/Info

Title:
Analysis of Peripheral Blood Lymphocyte Subsets in Patients with Novel Coronavirus Pneumonia
文章编号:
1671-7414(2021)02-114-04
作者:
孟凡萍郝 坡
(1.重庆三峡中心医院,重庆404000;2.重庆三峡医药高等专科学校,重庆400020)
Author(s):
MENG Fan-pingHAO Po
(1.Chongqing Three Gorges Central Hospital, Chongqing 404000, China;2. Chongqing Three Gorges Medical College,Chongqing 404000, China)
关键词:
新型冠状病毒新型冠状病毒肺炎淋巴细胞亚群
分类号:
R373.19;R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.027
文献标志码:
A
摘要:
目的 研究新型冠状病毒肺炎患者的淋巴细胞亚群的变化。方法 选取2020年2月于重庆三峡中心医院就诊的轻型冠状病毒肺炎患者(轻型组)35例、重型冠状病毒肺炎患者(重型组)11例,以健康体检者(NC组)20例为对照组,通过流式细胞检测三组淋巴细胞总数、T淋巴细胞(CD4+T,CD8+T,CD4+/CD8+)、B淋巴细胞数及NK细胞数量的变化。结果 两组患者的淋巴细胞总数、T淋巴细胞数(比例)、CD4+T细胞数(比例)、CD8+T细胞数(比例)、B淋巴细胞数(比例)、NK细胞数(比例)的差异均有统计学意义(t=-0.774~0.121,P<0.05),且重症组比轻症组降低的更为显著,差异具有统计学意义(t=-0.852~1.208,均P<0.05);两组患者的CD8+T细胞数和CD4+/CD8+较对照组有所升高(t=-0.142~0.256,P<0.05),但轻症组与重症组组间差异不明显,差异无统计学意义(P>0.05);两组患者B淋巴细胞数及B淋巴细胞比例较对照组显著升高(t=0.065,-0.352,P<0.05),且重症组明显高于轻症组(t=-0.744,-0.114,P<0.05),差异均有统计学意义;NK细胞比例在重症组可见明显升高(t=0.011,P<0.05),而在轻症组和对照组差异则无统计学意义(t=0.059~0.201,P>0.05)。结论 新型冠状病毒肺炎患者存在免疫功能紊乱,患者机体细胞免疫水平降低,重症患者可见免疫监视水平升高。

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备注/Memo

备注/Memo:
作者简介:孟凡萍(1980-),女,医学博士,副主任检验师,研究方向:脂代谢和胰岛素抵抗,E-mail:63405353@qq.com。
通讯作者:郝坡(1979-),男,医学硕士,副教授,研究方向:分子生物学检验,E-mail:hpo1979@126.com。
更新日期/Last Update: 2021-04-10