[1]师文涛,白 蓉,黄剑林,等.陕西省延安地区汉族与国内其他地区育龄妇女 MTHFR 基因 C677T 位点基因型和等位基因分布研究[J].现代检验医学杂志,2020,35(06):78-84.[doi:doi:10.3969/j.issn.1671-7414.2020.06.019]
 SHI Wen-tao,BAI Rong,HUANG Jian-lin,et al.Comparative Study on MTHFR Gene C677T Locus Genotype and AlleleDistribution between Han Nationality and Women of ChildbearingAge in Yan’an Area of Shaanxi Province[J].Journal of Modern Laboratory Medicine,2020,35(06):78-84.[doi:doi:10.3969/j.issn.1671-7414.2020.06.019]
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陕西省延安地区汉族与国内其他地区育龄妇女 MTHFR 基因 C677T 位点基因型和等位基因分布研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
78-84
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Comparative Study on MTHFR Gene C677T Locus Genotype and AlleleDistribution between Han Nationality and Women of ChildbearingAge in Yan’an Area of Shaanxi Province
文章编号:
1671-7414(2020)06-078-07
作者:
师文涛白 蓉黄剑林雷杰喻
(延安大学附属医院,陕西延安 716000)
Author(s):
SHI Wen-tao BAI Rong HUANG Jian-lin LEI Jie-yu
(the Affiliated Hospital of Yan’an University, Shaanxi Yan’an 716000,China)
关键词:
叶酸基因多态性亚甲基四氢叶酸还原酶出生缺陷
分类号:
R446.112;Q786
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.019
文献标志码:
A
摘要:
目的 调查并分析延安地区汉族育龄妇女亚甲基四氢叶酸还原酶(MTHFR)C677T 基因多态性的频率特征,指导育龄女性合理补充叶酸。方法 选取延安地区延安大学附属医院 12 557 例汉族育龄妇女进行 MTHFR C677T 基因分型检测,并和国内多地区相关报道进行比较分析。结果 延安地区 MTHFR C677T 位点基因的 CC,CT 和 TT 基因频率分别为 25.5%,50.4% 和 24.0%,与尚志、长春、辽源、延边、张家口、怀来、北京、廊坊、涞水、烟台、淄博、潍坊、新乡、济源、郑州、镇江、麻城、德阳、郫县、南充、武汉、遂宁、英山、荆州、松滋、眉山、绍兴、九江、长沙、湘潭、昆明、河源、广州、惠州、南宁、珠海和琼海比较差异均有统计学意义(χ 2 =8.01~1 167.916,P < 0.05),与乌鲁木齐比较差异无统计学意义(χ 2 =4.602,0.640,P > 0.05);MTHFR C677T 等位基因分布与基因型分布情况类似。结论 延安地区汉族育龄妇女 MTHFR C677T 基因多态性分布特征与其他地区相比,存在差异,且具有地域特异性。

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更新日期/Last Update: 2020-12-20