[1]彭　钧,李小月,王万俊,等.安徽省安庆地区健康体检人群幽门螺旋杆菌感染调查及免疫学分型研究[J].现代检验医学杂志,2021,36(01):18-21.[doi:10.3969/j.issn.1671-7414.2021.01.005]
　PENG Jun,LI Xiao-yue,WANG Wang-jun,et al.Investigation of Helicobacter Pylori Infection in Health Examination Population in Anqing Area[J].Journal of Modern Laboratory Medicine,2021,36(01):18-21.[doi:10.3969/j.issn.1671-7414.2021.01.005]
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安徽省安庆地区健康体检人群幽门螺旋杆菌感染调查及免疫学分型研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
18-21
栏目:
论　著
出版日期:
2021-02-05

文章信息/Info

Title:
Investigation of Helicobacter Pylori Infection in Health Examination Population in Anqing Area
文章编号:
1671-7414（2021）01-018-04
作者:
彭　钧; 李小月; 王万俊; 等
（1.安庆市市立医院病理科，安徽安庆 241000；2.安庆市第一人民医院，安徽安庆 241000）
Author(s):
PENG Jun;  LI Xiao-yue;  WANG Wang-jun;  et al
（1. Department of Pathology, Anqing Municipal Hospital, Anhui Anqing 241000, China; 2. the First People’s Hospital of Anqing, Anhui Anqing 241000, China）
关键词:
幽门螺旋杆菌; 免疫分型; 体检人群; 感染率
分类号:
R378.2；R446.5
DOI:
10.3969/j.issn.1671-7414.2021.01.005
文献标志码:
A
摘要:
目的　研究安徽省安庆地区健康体检人群幽门螺旋杆菌（ Helicobacter pylori, HP）的感染及免疫分型情况。方法　选取安庆市第一人民医院 2019年 4~8月健康体检人群 2 725例为研究对象，采用免疫印迹方法检测幽门螺旋杆菌抗体并进行分型，比较不同性别、年龄组的感染情况及免疫分型结果。结果　安庆地区 HP I，II型阳性率分别为 35.52%（968/2 725）和 16.81%（458/2 725）。其中 HP I型在男性和女性中阳性率分别为 20.22%（551/2 725）和 15.30%（417/2 725），差异有统计学意义（ χ2=8.108，P=0.004）。HP II型在男性和女性中阳性率分别为 9.72%(265/2 725）和 7.08%（193/2 725），差异无统计学意义（ χ2=1.622，P=0.203）。幽门螺旋杆菌阳性率随年龄增加而增加， 50~69岁最高， 70岁后有所降低，差异无统计学意义。结论　安庆地区健康体检人群幽门螺旋杆菌的感染率偏低，以 I型为主，男性多于女性，且随着年龄增长感染率增加。临床应把易感人群作为防治重点，针对性监测和治疗。

参考文献/References:

[1] 董欣红 ,胡伏莲 ,高文 ,等 .免疫印迹法检测幽门螺杆菌分型的多中心研究 [J].中华医学杂志， 2016,96(4): 265-269. DONG Xinhong, HU Fulian,GAO Wen, et al. Detection of Helicobacter pylori by immunoblot:a multiple-center study [J].National Medical Journal of China , 2016,96(4):265-269.
[2] 阚秉辉 ,孙丽红 ,吴春华 .健康体检者幽门螺旋杆菌感染检测结果分析 [J].国际检验医学杂志 ,2015,36(21):3164-3165. KAN Binghui, SUN Lihong,WU Chunhua. Analysis of detection results of Helicobacter pylori infection in healthy subjects[J] .International Journal of Laboratory Medicine,2015,36(21): 3164-3165.
[3] 于凌琪 .幽门螺旋杆菌的研究进展 [J].中国慢性病预防与控制，2010 ,18(2):218-219. YU Lingqi. Advances in research on Helicobacter pylori[J]. Chinese Journal of Prevention and Control of Chronic Diseases，2010,18(2) :218-219.
[4] BURKITT M D, DUCKWORTH C A, WILLIAMS J M, et al. Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models[J]. The Company of Biologists, 2017, 10(2):89-104.
[5] AMIEVA M R， EL-OMAR E M. Host-bacterial interactions in Helicobacter pylori infection[J]. Gastroenterology, 2008, 134(1):306-323.
[6] 杨舒 ,张雷 .幽门螺旋杆菌致病与免疫机制的研究进展 [J].中国病原生物学杂志 ,2017,12(3):283-285，后插 1. YANG Shu, ZHANG Lei. Advances in the study of pathogenic and immunologic mechanisms of Helicobacter pylori infection[J]. Journal of Parasitic Biology, 2017,12(3):283-285，After 1.
[7] 周雪亮 ,周渊 ,朱强 .幽门螺旋杆菌的研究进展 [J].中国继续医学教育 ,2018,10(33):101-104. ZHOU Xueliang, ZHOU Yuan, ZHU Qiang. Recent advance on Helicobacter pylori [J].China Continuing Medical Education,2018,10(33):101-104.
[8] 魏华，张蕾蕾，李艳，等． PG Ⅰ ,PG Ⅱ ,G-17和Hp Ig G抗体筛查慢性萎缩性胃炎和胃癌的价值 [J].中国免疫学杂志 , 2016, 32(9):1360-1363. WEI Hua, ZHANG Leilei, LI Yan, et al. Value of PGⅠ,P-G Ⅱ ,G-17 and Hp IgG in screening of chronic atrophic gastritis and gastric cancer[J]. Chinese Journal of Immu-nology, 2016, 32 (9) :1360-1363.
[9] 刘栋 ,翟笑枫 .幽门螺旋杆菌与肝癌相关性的研究进展 [J].现代肿瘤医学 , 2011, 19(5):1011-1013. LIU Dong，ZHAI Xiaofeng. The research advancement on the relevance between Helicobacter pylori and hepatic carcinoma[J].Journal of Modern Oncology, 2011,19(5):1011-1013.
[10] NAGY P，JOHANSSON S，MOLLOY -BLAND M. Systematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA [J]. Gut Pathogens, 2016, 8: 8.
[11] 刘青 ,黄婷婷 ,曹朝鹏 ,等 .体检人群幽门螺杆菌感染者血清葡萄糖、脂类及同型半胱氨酸水平与 HP抗体分型的相关分析 [J].现代检验医学杂志 , 2019,34(4):49-52, 57. LIU Qing, HUANG Tingting, CAO Zhaopeng, et al. Correlation analysis of serum Glucose, Lipid and Homocysteine levels in Helicobacter pylori infection patients with Hp antibody typing[J]. Journal of Modern Laboratory Medicine, 2019,34(4):49-52, 57.
[12] 张万岱 ,胡伏莲 ,萧树东 .中国自然人群幽门螺杆菌感染的流行病学调查 [J].现代消化及介入诊疗 ,2010,15(5):265-270. ZHANG Wandai, HU Fulian, XIAO Shudong, et al. Prevalence of Helicobacter pylori infection in China [J].Modern Digestion & Intervention，2010,15(5):265-270.
[13] 孙慧响，邹珍，黄跃平，等 .上海市某郊区社区人群幽门螺杆菌感染的流行病学调查 [J].上海预防医学 ,2018,30(4):295-298. SUN Huixiang, ZOU Zhen, HUANG Yueping, et al. Epidemiological survey on Helicobacter pylori infection among Shanghai suburb residents[J]. Shanghai Journal of Preventive Medicine,2018,30(4):295-298.
[14] 张艳君，刘奕婷，于晓松．健康体检人群幽门螺杆菌感染情况与相关因素分析 [J]．临床军医杂志， 2015, 43(11): 1139-1142. ZHANG Yanjun, LIU Yiting, YU Xiaosong. Helicobacter pylori infection stations in health check-up population and correlation factors analysis[J]． Clinical Journal of Medical Officers, 2015, 43(11): 1139-1142.
[15] 郑冬图，张荷，斯银平 .2 220例健康体检人群幽门螺杆菌感染状况分析 [J]．中国疗养医学， 2015， 24( 2): 180-181． ZHENG Dongtu, ZHANG He, SI Yinping. Analysis of present status of Helicobacter pylori infection stations in 2220 physical examination population[J].Chinese Journal of Convalescent Medicine, 2015, 24( 2): 180-181．
[16] 邓学洁，屈小英，向林，等．重庆城市体检人群幽门螺杆菌感染 3年流行趋势分析 [J].中国实验诊断学 , 2011, 15(12):2055-2057. DENG Xuejie , QU Xiaoying , XIAO Lin , et al. Epidemiological survey on Helicobacter pylori infection in the residents undergoing physical examination in the three years[J].Chinese Journal of Laboratory Diagnosis, 2011, 15(12):2055-2057.
[17] 刘雄 ,李兵 ,任佳 ,等 .体检人群幽门螺旋杆菌感染的流行病学调查 [J].西南国防医药 ,2012, 22(8):925-926. LIU Xiong, LI Bing, REN Jia, et al. Epidemiological investigation of Helicobacter pylori infection in physical examination population[J].Medical Journal of National Defending Forces in Southwest China,2012, 22(8):925-926.
[18] 于晓辉 ,赵红珍 ,李晓云 ,等 .兰州市健康体检人群幽门螺杆菌感染情况调查 [J].胃肠病学 ,2016,21(11):687-689. YU Xiaohui, ZHAO Hongzhen, LI Xiaoyun, et al. Survey of Helicobacter pylori infection in physical examination population in Lanzhou,Gansu Province[J]. Chinese Journal of Gastroenterolo gy,2016,21(11):687-689.
[19] JANG S H, LEE H, KIM J S, et al. Association between Helicobacter pylori infection and cerebral small vessel disease[J]. Korean Journal of Family Medicine, 2015, 36(5): 227-232.
[20] 李兴川，王海东，张妮，等．中国儿童及青少年幽门螺杆菌感染流行病学调查的系统评价和 meta 分析 [J].临床儿科杂志 , 2017, 35(10):10782-10787. LI Xingchuan ,WANG Haidong ,ZHANG Ni .Systematic review and meta-analysis of epidemiological investigation of Helicobacter pylori infection in children and adolescents in China[J].J Clin Pediatr, 2017, 35(10):10782-10787.
[21] SERVETAS S L, BRIDGE D R, MERRELL D S. Molecular mechanisms of gastric cancer initiation and progression by Helicobacter pylori[J]. Current Opinion in Infectious Diseases, 2016, 29(3): 304-310.
[22] FORD A C, FORMAN D, HUNT R H, et al. Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials[J]. BMJ，2014, 348:g3174.
[23] 邓兆享，林文浩，常东 .免疫印迹法检测幽门螺旋杆菌及其分型与上消化道疾病的关系 [J].现代医药卫生 ,2017,33(24):3723-3725，3729. DENG Zhaoxiang, LIN Wenhao, CHANG Dong. Western blot for detecting Helicobacter pylori and relationship between its typing and upper digestive tract diseases[J]. Journal of Modern Medicine & Health, 2017,33(24):3723-3725,3729.

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备注/Memo

备注/Memo:
基金项目：安徽省重点研究和开发计划项目（编号：201904a07020016）。
作者简介：彭钧（1973-），男，副主任医师，从事肿瘤病理研究， E-mail：741092503@qq.com。
通讯作者：李小月（1974-），女，博士，副高职称，从事分子诊断及流行病学研究， E-mail：18496701@qq.com。
更新日期/Last Update: 2021-02-05