[1]王 玲,王 健,赵寅生,等.甲状腺乳头状癌患者血清促甲状腺激素水平和组织促甲状腺激素受体检测的临床应用价值[J].现代检验医学杂志,2021,36(01):61-64.[doi:10.3969/j.issn.1671-7414.2021.01.016]
 WANG Ling,WANG Jian,ZHAO Yin-sheng,et al.Clinical Application Value of Serum Thyrotropin Level and Tissue Thyrotropin Receptor Detection in Patients with Thyroid Papillary Carcinoma[J].Journal of Modern Laboratory Medicine,2021,36(01):61-64.[doi:10.3969/j.issn.1671-7414.2021.01.016]
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甲状腺乳头状癌患者血清促甲状腺激素水平和组织促甲状腺激素受体检测的临床应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
61-64
栏目:
论 著
出版日期:
2021-02-05

文章信息/Info

Title:
Clinical Application Value of Serum Thyrotropin Level and Tissue Thyrotropin Receptor Detection in Patients with Thyroid Papillary Carcinoma
文章编号:
1671-7414(2021)01-061-04
作者:
王 玲王 健赵寅生
(中国人民解放军联勤保障部队第 901医院 a.检验科;b.病理科 ,合肥 230001)
Author(s):
WANG Ling WANG Jian ZHAO Yin-sheng et al
(a.Department of Clincal Laboratory; b. Department of Pathology,the 901th Hospital of People’s Liberation, Hefei 230001,China)
关键词:
甲状腺乳头状癌结节性甲状腺肿促甲状腺激素受体促甲状腺激素
分类号:
R736.1;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.01.016
文献标志码:
A
摘要:
目的 探讨血清中促甲状腺激素( thyroid stimulating hormone,TSH)和甲状腺组织中促甲状腺激素受体(thyroid stimulating hormone recepter,TSHR)在甲状腺乳头状癌( papillary thyroid carcinoma,PTC)中的应用价值。方法 收集甲状腺乳头状癌标本 55例,结节性甲状腺肿标本 32例,采用化学发光法检测血清中 TSH和免疫组化法检测甲状腺组织中 TSHR的表达。结果 PTC中血清 TSH水平明显高于结节性甲状腺肿,差异具有统计学意义( χ2=-2.163,P<0.05);且 PTC中,Ⅲ /Ⅳ期患者的血清 TSH水平明显高于Ⅰ /Ⅱ期,差异具有统计学意义( χ2=-2.037, P<0.05);血清 TSH的水平与患者年龄、性别、淋巴结转移与否和肿瘤大小,差异均无统计学意义( Z=-0.024~-1.262,均 P >0.05)。TSHR在 PTC中的表达阳性率明显低于结节性甲状腺肿,差异具有统计学意义( χ2=4.845,P<0.05);PTC中, Ⅰ /Ⅱ期的表达阳性率高于Ⅲ /Ⅳ期,淋巴结未转移组的表达阳性率明显高于淋巴结转移组,差异具有统计学意义(Z=-3.097,-2.423,均 P <0.05);TSHR的表达与患者年龄、性别和肿瘤大小,差异均无统计学意义( Z=-0.846~-1.73,均 P >0.05)。结论 血清 TSH水平与 PTC发病和 TNM分期有关; TSHR的表达与 PTC发病、 TNM分期和淋巴结转移与否有关,两者可以作为 PTC诊断和预后判断的一项参考指标。

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备注/Memo

备注/Memo:
作者简介:王玲(1985-),女,学士,主管技师,主要研究分子免疫学, E-mail: 278223498@qq.com。
通讯作者:吴黎黎,女,硕士,主管技师,主要研究分子免疫学,E-mail: 254332372@qq.com。
更新日期/Last Update: 2021-02-05