[1]姚伟莉,袁 静,耿 彪,等.慢性牙周炎患者唾液中 miR-1246的表达及其临床意义[J].现代检验医学杂志,2021,36(01):65-67.[doi:10.3969/j.issn.1671-7414.2021.01.017]
 YAO Wei-li,YUAN Jing,GENG Biao,et al.Expression of miR-1246 in Saliva of Patients with Chronic Periodontitis and Its Clinical Significance[J].Journal of Modern Laboratory Medicine,2021,36(01):65-67.[doi:10.3969/j.issn.1671-7414.2021.01.017]
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慢性牙周炎患者唾液中 miR-1246的表达及其临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
65-67
栏目:
论 著
出版日期:
2021-02-05

文章信息/Info

Title:
Expression of miR-1246 in Saliva of Patients with Chronic Periodontitis and Its Clinical Significance
文章编号:
1671-7414(2021)01-065-03
作者:
姚伟莉 袁 静耿 彪
(保定市第二中心医院检验科,河北涿州 072750)
Author(s):
YAO Wei-li YUAN Jing GENG Biao et al
(Department of Clinical Laboratory,the Second Central Hospital of Baoding, Hebei Zhuozhou 072750,China)
关键词:
慢性牙周炎miR-1246
分类号:
R781.42;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.01.017
文献标志码:
A
摘要:
目的 探讨慢性牙周炎( CP)患者唾液中 miR-1246的表达及其临床意义。方法 选取 2017年 1月 ~2019年 5月保定市第二中心医院收治的 94例 CP患者作为 CP组和 50例体检正常者作为对照组。 CP患者分为轻度牙周炎组(n=23),中度牙周炎组( n=37)和重度牙周炎组( n=35),检测各组唾液中 miR-1246的表达水平。对 CP患者进行牙周基础治疗,分别检测治疗前和治疗 6周后患者唾液中 miR-1246的表达水平,并检查牙周探诊深度 (PD),附着丧失 (AL),菌斑指数 (PLI) 和出血指数( BI)各项牙周临床指标。采用 Pearson相关分析 CP患者 miR-1246表达水平与 PD,AL, PLI及 BI的相关性。结果 CP组唾液中 miR-1246表达水平明显高于对照组( 7.28±2.56 vs 3.52±1.14),差异有统计学意义( t=16.294,均 P<0.01)。重度组唾液中 miR-1246表达水平均明显高于中度组和轻度组( 10.47±3.38 vs 7.38±2.70, 4.24±1.30),差异有统计学意义( t=13.516,21.482,P<0.01)。CP患者治疗后唾液中 miR-1246表达水平明显低于治疗前( 4.75±1.61 vs 7.28±2.56),差异有统计学意义(t=10.490,P<0.01)。CP患者治疗后 PD(2.84±0.72mm vs 5.16±1.30 mm),AL(3.08±0.64mm vs 5.62±1.15 mm),PLI(1.13±0.28 vs 2.62±0.41)及 BI(2.95±0.58 vs 1.64±0.47)均明显低于治疗前,差异均有统计学意义( t=8.742~10.873,均 P<0.01)。相关分析显示,治疗前后 CP患者 miR-1246表达水平与 PD,AL,PLI及 BI均呈正相关( r=0.592~0.874,均 P<0.01)。结论 CP患者唾液中 miR-1246表达水平明显升高,治疗后明显下降,其表达水平与 CP严重程度和牙周炎临床指标密切相关,有望为 CP的防治提供新的思路。

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:姚伟莉(1982-) ,女,本科,主管检验师,主要从事临床检验诊断研究,E-mail: zpj920@163.com。
更新日期/Last Update: 2021-02-05