[1]高 旋,杨丰钒,刘 薇,等.系统性红斑狼疮患者血清 IgG水平正常及升高与相关免疫学实验室指标的相关分析[J].现代检验医学杂志,2021,36(01):68-71.[doi:10.3969/j.issn.1671-7414.2021.01.018]
 GAO Xuan,YANG Feng-fan,LIU Wei,et al.Correlation Analysis between Normal and Elevated Serum IgG Levels and Related Immunological Laboratory Indexes in Patients with Systemic Lupus Erythematosus[J].Journal of Modern Laboratory Medicine,2021,36(01):68-71.[doi:10.3969/j.issn.1671-7414.2021.01.018]
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系统性红斑狼疮患者血清 IgG水平正常及升高与相关免疫学实验室指标的相关分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
68-71
栏目:
论 著
出版日期:
2021-02-05

文章信息/Info

Title:
Correlation Analysis between Normal and Elevated Serum IgG Levels and Related Immunological Laboratory Indexes in Patients with Systemic Lupus Erythematosus
文章编号:
1671-7414(2021)01-068-04
作者:
高 旋杨丰钒刘 薇
(空军军医大学第一附属医院临床免疫科 , 西安 710032)
Author(s):
GAO Xuan YANG Feng-fan LIU Wei et al
(Department of Clinical Immunology, the First Affiliated Hospital of Air Force Medical University, Xi’an 710032, China)
关键词:
系统性红斑狼疮免疫球蛋白补体抗核抗体抗双链 DNA抗体抗可溶性抗原抗体谱
分类号:
R593.241;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.01.018
文献标志码:
A
摘要:
目的 探讨系统性红斑狼疮患者( systemic lupus erythematosus,SLE)中免疫球蛋白 G (immunoglobulin G,IgG)正常与 IgG升高的患者,其抗核抗体 (antinuclear antibody, ANA)滴度、抗双链 DNA(double-strand DNA,ds-DNA)抗体及抗可溶性抗原抗体谱( extractable nuclear antigen,ENA),以便深入对 SLE的认识。方法 选择 2019年 6~12月在空军军医大学第一附属医院就诊的初诊 SLE患者 150例,其中狼疮性肾炎患者 62例,采用速率散射比浊法分别检测 SLE患者血清中免疫球蛋白 IgA,IgG,IgM及补体 C3,C4的水平。采用间接免疫荧光法和欧蒙印迹法检测抗核抗体 ANA,抗 ds-DNA抗体及 ENA。比较 IgG正常组与 IgG升高组患者间实验室指标的差异。结果 IgG正常组 SLE患者血清中免疫球蛋白 IgA,IgM水平低于 IgG升高组,补体 C3,C4水平高于 IgG升高组,其中 IgA差异具有统计学意义 (z=-3.64, P<0.05)。IgG正常组 SLE患者抗 ds-DNA抗体、抗舍格伦综合征 A(SSA)抗体、抗 Ro-52抗体、抗核小体抗体(AnuA)阳性率均低于 IgG升高组 (χ2=4.985,7.479,8.974和 5.637,均 P<0.05);而抗核糖核蛋白 /史密斯( nRNP/ Sm)抗体、抗 Sm抗体、抗舍格伦综合征 B(SSB)抗体、抗组蛋白抗体( AHA)、抗核糖体 P蛋白抗体 (ARPA)在两组之间差异无统计学意义 (χ2=0.005~2.050,均 P>0.05)。两组患者的狼疮性肾炎患病率相似,差异无统计学意义( χ2=1.129, P>0.05)。结论 IgG正常 SLE患者与 IgG升高患者相比,其自身抗体阳性率降低,而狼疮肾炎发病率与 IgG升高组无差异,提示临床 IgG正常和 IgG升高的 SLE患者实验室指标之间存在差异,以便加深对 SLE的认识。

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备注/Memo

备注/Memo:
作者简介:高旋(1987-),女,学士,主管技师,主要研究方向:自身免疫疾病的实验室诊断, E-mail:237543548@qq.com。
通讯作者:丁进(1978-),女,博士,副主任医师,主要研究方向:自身免疫疾病的研究, E-mail:dingjin@fmmy.edu.cn。
更新日期/Last Update: 2021-02-05