[1]潘良明,沈菲菲,马晓英,等.血清前列腺健康指数对 tPSA灰区前列腺癌患者的诊断价值探讨[J].现代检验医学杂志,2021,36(01):72-76.[doi:10.3969/j.issn.1671-7414.2021.01.019]
 PAN Liang-ming,SHEN Fei-fei,MA Xiao-ying,et al.Diagnostic Value of Serum Prostate Health Index in Prostate Cancer Patients with PSA Gray Area[J].Journal of Modern Laboratory Medicine,2021,36(01):72-76.[doi:10.3969/j.issn.1671-7414.2021.01.019]
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血清前列腺健康指数对 tPSA灰区前列腺癌患者的诊断价值探讨()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
72-76
栏目:
论 著
出版日期:
2021-02-05

文章信息/Info

Title:
Diagnostic Value of Serum Prostate Health Index in Prostate Cancer Patients with PSA Gray Area
文章编号:
1671-7414(2021)01-072-06
作者:
潘良明沈菲菲马晓英
(上海市金山区亭林医院 a.泌尿外科;b.康复科;c.急诊科 ,上海 201505)
Author(s):
PAN Liang-ming SHEN Fei-fei MA Xiao-ying et al
(a.Department of Urology; b. Department of Rehabilitation; c. Department of Emergency,Shanghai Jinshan District Tinglin Hospital,Shanghai 201505,China)
关键词:
前列腺健康指数前列腺癌前列腺特应性抗原诊断
分类号:
R737.25;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.01.019
文献标志码:
A
摘要:
目的 探讨前列腺健康指数(PHI)在血清总前列腺特应性抗原(tPSA)灰区(4~10 ng/ml)前列腺癌(PCa)患者中的诊断价值。方法 选择 2018年 3月~ 2019年 10月上海市金山区亭林医院泌尿外科收治的 94例血清 tPSA在 4~ 10 ng/ml的老年男性患者临床资料。其中 PCa组 21例,前列腺良性增生( BPH)73例。检测两组患者血清中 tPSA、游离 PSA(fPSA)以及前列腺特异性抗原前体 2型(p2PSA)的指标水平,从而计算得出 fPSA/tPSA比值和 PHI,并绘制 tPSA, fPSA/tPSA, p2PSA以及 PHI的受试者工作特征( ROC)曲线,得出曲线下面积( AUC)、95%CI以及截断值( cut off value),分析 tPSA, fPSA/tPSA, p2PSA以及 PHI的检测对 PCa患者的早期诊断价值。结果 两组患者的血清 tPSA,fPSA和p2PSA水平差异均无统计学意义(U=899,450和 261.5,均 P >0.05);两组患者 fPSA/tPSA(U=261.5, P =0.023)与 PHI(t=1275.5,P<0.001)指标的差异有统计学意义(均 P <0.05)。tPSA, fPSA/tPSA, p2PSA以及 PHI的 ROC曲线下面积分别为 0.586,0.676,0.613和 0.832,其中 tPSA, fPSA/tPSA和 p2PSA(AUC值均 <0.7)的诊断效能较低,而 PHI的诊断效能较高。血清 PHI的准确度( 81.9%)明显高于 tPSA, fPSA/tPSA和 p2PSA,差异有统计学意义( χ2=6.975, 4.145和 6.211, 均 P <0.05)。tPSA及 p2PSA指标对提高 PCa的诊断效率无明显助益(均 P >0.05),fPSA/tPSA和 PHI明显提高 Pca的诊断效力( P<0.05),其中 PHI的诊断效果最佳( P<0.001),PHI的 AUC值 0.832(95% CI: 0.733~ 0.931)高于 fPSA/tPSA的 AUC值 0.676(95% CI: 0.539~ 0.812),差异有统计学意义(Z=2.758,P<0.01)。结论 PHI诊断 tPSA灰区 PCa患者的诊断效能与准确性均较高,具有比 tPSA, fPSA/tPSA和 p2PSA更高的诊断价值。

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备注/Memo

备注/Memo:
基金项目:上海市金山区科委课题(课题编号:2016-3-25)。
作者简介:潘良明(1981-),男,本科,主治医师,研究方向:泌尿系结石,泌尿系肿瘤, E-mail:plm_8750@163.com。
通讯作者:沈建良,副主任医师,E-mail:shenjl76@163.com。
更新日期/Last Update: 2021-02-05