[1]张　劲,明　媚.增生性糖尿病视网膜病变患者玻璃体、房水和血浆中VEGF表达与IL-6，IL-8和TNF-α水平的相关性研究[J].现代检验医学杂志,2021,36(04):55-59.[doi:10.3969/j.issn.1671-7414.2021.04.012]
　ZHANG Jin,MING Mei.Correlation of VEGF Expression with IL-6, IL-8 and TNF-α Levels inVitreous Body, Aqueous Humor and Plasma of Patients with ProliferativeDiabetic Retinopathy[J].Journal of Modern Laboratory Medicine,2021,36(04):55-59.[doi:10.3969/j.issn.1671-7414.2021.04.012]
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增生性糖尿病视网膜病变患者玻璃体、房水和血浆中VEGF表达与IL-6，IL-8和TNF-α水平的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
55-59
栏目:
论　著
出版日期:
2021-07-31

文章信息/Info

Title:
Correlation of VEGF Expression with IL-6, IL-8 and TNF-α Levels inVitreous Body, Aqueous Humor and Plasma of Patients with ProliferativeDiabetic Retinopathy
文章编号:
1671-7414（2021）04-055-05
作者:
张　劲;  明　媚
(鄂东医疗集团中心医院, 湖北黄石 435000)
Author(s):
ZHANG Jin; MING Mei
(Central Hospital of Edong Healthcare，Hubei Huangshi 435000，China)
关键词:
增生性糖尿病视网膜病变（PDR）; 玻璃体; 房水; 血浆; 白细胞介素-6; 白细胞介素-8; 肿瘤坏死因子-α; 血管内皮生长因子
分类号:
R587.2；R392.11
DOI:
10.3969/j.issn.1671-7414.2021.04.012
文献标志码:
A
摘要:
目的　探讨增生性糖尿病视网膜病变（proliferative diabetic retinopathy，PDR）患者玻璃体、房水、血浆中血管内皮生长因子（VEGF）和白细胞介素6(IL-6)，白细胞介素8(IL-8)，肿瘤坏死因子-α（TNF-α）的相关性。方法　选择2016 年5 月~2019 年6 月鄂东医疗集团中心医院眼科收治的76 例行玻璃体切割治疗的PDR 患者（PDR 组）和42 例行超声乳化白内障吸除术治疗的白内障患者（对照组）。PDR 组采集血浆、房水和玻璃体标本，对照组采集血浆和房水，采用酶联免疫吸附法检测VEGF，IL-6，IL-8 和TNF-α 水平。比较PDR 组、对照组血浆、房水中VEGF，IL-6，IL-8 和TNF-α 水平差异以及PDR 组血浆、房水和玻璃体VEGF，IL-6，IL-8 和TNF-α 水平差异。Pearson 相关性分析PDR 组血浆、房水和玻璃体中VEGF 与IL-6，IL-8，TNF-α 相关性。结果　PDR 组血浆、房水中VEGF，IL-6，IL-8 和TNF-α 水平分别为53.51±10.62 pg/ml，125.64±15.34 pg/ml，102.35±11.35 pg/ml，12.65±3.26 ng/ml和332.16±26.35 pg/ml，295.25±21.43 pg/ml，261.35±25.49 pg/ml，21.26±4.26 ng/ml，均高于对照组，差异有统计学意义（t=22.418，37.409，42.754，15.959；71.433，54.329，41.620，5.435，均P ＜ 0.05）。PDR 患者玻璃体VEGF，IL-6，IL-8 和TNF-α 水平高于房水和血浆（F=46.359，58.265，47.265，39.562，P ＜ 0.05），房水VEGF，IL-6，IL-8和TNF-α 水平高于血浆（均P ＜ 0.05），差异均有统计学意义。Pearson 相关性分析结果显示PDR 患者玻璃体 VEGF水平与IL-6，IL-8，TNF-α 呈正相关（r=0.841，0.800，0.787，均P ＜ 0.05），血浆、房水中VEGF 水平与IL-6，IL-8和TNF-α 无相关性（r=0.461，0.565，0.439；0.218，0.131，0.210，均P ＞ 0.05）。结论　玻璃体是PDR 视网膜病理事件的主要场所，IL-6，IL-8，TNF-α 可能通过促使VEGF 表达参与PDR 视网膜新生血管形成过程。

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备注/Memo

备注/Memo:
基金项目：湖北省卫生厅科研项目：JX6B110。
作者简介：张劲（1970-），男，本科，副主任医师，研究方向：眼外伤、泪器疾病，E-mail：3121274260@qq.com。
通讯作者：明媚（1986-），女，硕士，主治医师， 研究方向：玻璃体视网膜疾病，E-mail：276949485@qq .com。
更新日期/Last Update: 1900-01-01