[1]陈静非,徐志昊,高媛雪,等.MTHFR基因多态性与脊髓亚急性联合变性的相关性分析[J].现代检验医学杂志,2021,36(04):64-67.[doi:10.3969/j.issn.1671-7414.2021.04.014]
 CHEN Jing-fei,XU Zhi-hao,GAO Yuan-xue,et al.Correlation between 5,10-Methylenetetrahydrofolate Reductase GenePolymorphism and Subacute Combined Degeneration[J].Journal of Modern Laboratory Medicine,2021,36(04):64-67.[doi:10.3969/j.issn.1671-7414.2021.04.014]
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MTHFR基因多态性与脊髓亚急性联合变性的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
64-67
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Correlation between 5,10-Methylenetetrahydrofolate Reductase GenePolymorphism and Subacute Combined Degeneration
文章编号:
1671-7414(2021)04-064-05
作者:
陈静非徐志昊高媛雪李建刚鱼 海张建军侯瑞华
( 宝鸡市中心医院神经内科,陕西宝鸡 721000)
Author(s):
CHEN Jing-fei XU Zhi-hao GAO Yuan-xue LI Jian-gang YU Hai ZHANG Jian-junHOU Rui-hua
(Department of Neurology, Baoji Central Hospital ,Shaanxi Baoji 721000, China)
关键词:
脊髓亚急性联合变性510- 亚甲基四氢叶酸还原酶基因多态性
分类号:
R744.6;Q786
DOI:
10.3969/j.issn.1671-7414.2021.04.014
文献标志码:
A
摘要:
目的 探讨5,10- 亚甲基四氢叶酸还原酶(MTHFR)基因C677T 位点和A1298C 位点多态性与脊髓亚急性联合变性(SCD)的关系。方法 选择2017 年1 月~ 2020 年7 月于宝鸡市中心医院神经内科诊治的85 例SCD 患者作为病例组,另外募集100 例健康体检者作为对照组。采用荧光定量PCR 法检测MTHFR 基因C677T和A1298C 位点多态性,比较各组两位点基因型和等位基因频率,分析两位点多态性与SCD 发病的相关性。结果 病例组C677T 位点TT 基因型和T 等位基因频率均高于对照组(χ2=10.527,11.144,均P < 0.05),A1298C 位点CC 基因型和C 等位基因频率均高于对照组(χ2=6.575,6.076,均P < 0.05),差异均有统计学意义。C677T位点和A1298C 位点基因多态性均与同型半胱氨酸水平增高密切相关(χ2=19.625,10.786,均P < 0.05);与血清VitB12 和叶酸水平均无明确相关性(χ2=1.827~5.549,均P > 0.05)。多因素分析示携带C677T 位点TT 基因型是SCD 发病的独立危险因素(OR=2.768,95% CI:1.487~5.516,P=0.005),A1298C 位点基因多态性与SCD发病无明确相关性(OR=2.190,95% CI:0.958~5.004,P=0.067)。结论 MTHFR 基因C677T 位点突变与SCD发病密切相关。

参考文献/References:

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相似文献/References:

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 ZHANG Xin,LIU Xi-ling,LIU Yue.Diagnostic Value of Detecting Plasma Vitamin B12 and Homocysteine Subacute Combined Degeneration of the Spinal Cord[J].Journal of Modern Laboratory Medicine,2017,32(04):43.[doi:10.3969/j.issn.1671-7414.2017.04.012]
[2]罗晓琴,江 平,程时磊.青海地区育龄女性MTHFR基因C677位点的多态性研究[J].现代检验医学杂志,2021,36(02):89.[doi:doi:10.3969/j.issn.1671-7414.2021.02.021]
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备注/Memo

备注/Memo:
作者简介:陈静非(1987-),女,硕士,主治医师,研究方向:脑血管病,E-mail:baijichenjf87@163.com。
通讯作者:徐志昊(1988-),男,硕士,主治医师,研究方向:神经病学,E-mail:baojixuzhihao88@163.com。
更新日期/Last Update: 1900-01-01