[1]刘慧丽,王雪莹,姚莉芸,等.孕妇血清THBS-1，AT-Ⅲ和25(OH)D表达水平对产后出血的预测价值分析[J].现代检验医学杂志,2021,36(04):106-110.[doi:10.3969/j.issn.1671-7414.2021.04.022]
　LIU Hui-li,WANG Xue-ying,YAO Li-yun,et al.Predictive Value Analysis of Maternal Serum THBS-1, AT-Ⅲ and 25(OH)D Expression Levels for Postpartum Hemorrhage[J].Journal of Modern Laboratory Medicine,2021,36(04):106-110.[doi:10.3969/j.issn.1671-7414.2021.04.022]
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孕妇血清THBS-1，AT-Ⅲ和25(OH)D表达水平对产后出血的预测价值分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
106-110
栏目:
论　著
出版日期:
2021-07-31

文章信息/Info

Title:
Predictive Value Analysis of Maternal Serum THBS-1, AT-Ⅲ and 25(OH)D Expression Levels for Postpartum Hemorrhage
文章编号:
1671-7414（2021）04-106-05
作者:
刘慧丽; 王雪莹; 姚莉芸; 石国素; 唐连敏; 郝俊兰
（邢台市第三医院产一科, 河北邢台 054000）
Author(s):
LIU Hui-li;  WANG Xue-ying;  YAO Li-yun;  SHI Guo-su;  TANG Lian-min;  HAO Jun-lan
（the First Department of Obstetrics and Gynecology, Xingtai Third Hospital, Hebei Xingtai 054000, China）
关键词:
血小板反应蛋白1; 抗凝血酶-Ⅲ; 25羟维生素D; 产后出血
分类号:
R714.461；R446.112
DOI:
10.3969/j.issn.1671-7414.2021.04.022
文献标志码:
A
摘要:
目的　分析孕妇血清血小板反应蛋白1(THBS-1)、抗凝血酶-Ⅲ(AT-Ⅲ)和25羟维生素D[25(OH)D]表达水平对产后出血(PPH)的预测价值。方法　选取邢台市第三医院产科2018年1月~2019年1月收治的118例住院分娩孕产妇，根据分娩后是否PPH分为PPH组(n=40)和无PPH组(n=78)，对比两组产妇基本资料和血清THBS-1，AT-Ⅲ和25(OH)D水平，多因素Logistics回归分析产妇PPH危险因素，ROC曲线分析血清THBS-1，AT-Ⅲ和25(OH)D水平对产妇PPH的预测价值。结果　PPH组流产史比例、剖宫产比例、宫缩乏力比例、软产道损伤比例、产程延长比例和血清THBS-1水平明显高于无PPH组，AT-Ⅲ和25(OH)D水平明显低于无PPH组，差异均有统计学意义(均P＜0.05)。多因素Logistics回归分析显示，宫缩乏力(OR=2.853，95%CI 1.118~4.972)、软产道损伤(OR=1.429，95%CI 1.004~1.936)、产程延长(OR=1.090，95%CI 0.524~1.183)和THBS-1(OR=1.020，95%CI 1.006~1.033)为产妇PPH独立危险因素，AT-Ⅲ(OR=0.879，95%CI 0.829~0.932)和25(OH)D(OR=0.701，95%CI 0.574~0.856)为独立保护因素(P＜0.05)。ROC曲线显示，THBS-1+AT-Ⅲ+25(OH)D联合检测(OR=0.917，95%CI 0.852~0.960)预测产妇PPH的敏感度和特异度高于THBS-1(OR=0.696，95%CI：0.605~0.777)，AT-Ⅲ(OR=0.819，95%CI 0.738~0.884)，25(OH)D(OR=0.741，95%CI 0.652~0.817)预测。结论　PPH产妇血清THBS-1水平明显提升，AT-Ⅲ和25(OH)D水平明显降低，为PPH独立影响因素，联合检测可提升PPH预测价值。

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备注/Memo

备注/Memo:
基金项目：邢台市科技计划项目：EENC联合产后穴位按摩对自然分娩产后出血的影响研究，项目编号：2019ZC216。
作者简介：刘慧丽（1980-），女，本科/学士，副主任医师，研究方向：产科，E-mail：lhli588@126.com。
更新日期/Last Update: 1900-01-01