[1]符征高,陈 钰,梁 勇,等.重症肺炎患者血清Fn,Copeptin及sTREM-1水平变化及临床意义[J].现代检验医学杂志,2021,36(04):111-115.[doi:10.3969/j.issn.1671-7414.2021.04.023]
 FU Zheng-gao,CHEN Yu,LIANG Yong,et al.Changes and Clinical Significance of Serum Levels of Fn, Copeptin andsTREM-1 in Patients with Severe Pneumonia[J].Journal of Modern Laboratory Medicine,2021,36(04):111-115.[doi:10.3969/j.issn.1671-7414.2021.04.023]
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重症肺炎患者血清Fn,Copeptin及sTREM-1水平变化及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
111-115
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Changes and Clinical Significance of Serum Levels of Fn, Copeptin andsTREM-1 in Patients with Severe Pneumonia
文章编号:
1671-7414(2021)04-111-05
作者:
符征高陈 钰梁 勇许俊旭吴挺实郝金香
(海口市第三人民医院,海口 571100)
Author(s):
FU Zheng-gao CHEN Yu LIANG Yong XU Jun-xu WU Ting-shi YU Jin-xiang
(the Third People’s Hospital of Haikou City, Haikou 571100,China)
关键词:
重症肺炎纤维结合蛋白和肽素可溶性髓样细胞触发受体1
分类号:
R563.1;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.04.023
文献标志码:
A
摘要:
目的 观察重症肺炎患者血清纤维结合蛋白(Fn)、和肽素(Copeptin)、可溶性髓样细胞触发受体1(sTREM-1)水平变化,分析其与病情严重程度以及预后的关系。方法 选择122 例社区获得性重症肺炎患者(肺炎组),根据APACHE Ⅱ将患者分为低危组(< 10 分,45 例),中危组(10~20 分,43 例)和高危组(> 20分,34 例),根据28 天内生存情况分为死亡组(31 例)和存活组(91 例),另选择92 例健康志愿者为对照组。检测血清Fn,Copeptin 和sTREM-1 水平,分析其与重症肺炎患者病情和预后的关系。结果 肺炎组血清Fn 水平为177.26±31.94mg/L,低于对照组231.26±21.54mg/L(t=8.751,P < 0.001),血清Copeptin 和sTREM-1 水平分别为70.45±0.47pmol/L,169.26±31.94pg/ml, 高于对照组的55.45±7.06pmol/L 和34.18±9.54pg/ml(t=12.637,39.235,P < 0.001)。血清Copeptin 和sTREM-1 水平在低危组、中危组、高危组依次升高,Fn 水平依次降低,各组间差异均有统计学意义(均P < 0.05)。治疗后肺炎患者血清Fn 水平升高(t=8.977,P < 0.05),Copeptin 和sTREM-1 水平降低(t=20.941,31.982,均P < 0.05)。死亡组血清Fn 和sTREM-1 水平低于存活组(t=6.377,8.285,均P < 0.001),血清Copeptin 水平高于存活组(t=7.845,P < 0.001)。血清Fn 水平与CPIS 评分,APACHE Ⅱ评分呈负相关(rs=-0.569,-0.632,均P < 0.001),与OI 指数呈正相关(r=0.496,P < 0.01)。血清Copeptin,sTREM-1 水平与CPIS 评分,APACHE Ⅱ评分呈正相关(rs=0.573,0.603,0.517 和0.529,均P < 0.001),与OI 指数呈负相关(r=-0.437,-0.506,均P < 0.01)。低水平Fn(OR=0.768,95%CI:0.617~0.806),高水平Copeptin(OR=1.650,95%CI:1.523~1.769),高水平sTREM-1(OR=1.602,95%CI:1.543 ~ 1.732)是重症肺炎患者死亡的危险因素(P< 0.01)。结论 重症肺炎患者血清Fn 水平降低,Copeptin,sTREM-1 水平升高,低水平Fn,高水平Copeptin 和sTREM-1 与患者病情加重和不良预后有关。

参考文献/References:

[1] 林洁如,许梅,叶贤伟,等.重症肺炎患者血清可溶性细胞黏附因子的检测及意义[J]. 贵州医科大学学报,2019,44(11):1349-1353.LIN Jieru,XU Mei,YE Xianwei,et al. Serum levels ofsoluble vascular endothelial cell selectin in patientswith severe pneumonia [J]. Journal of Guizhou MedicalUniversity, 2019,44(11):1349-1353.
[2] SPEZIALE P, ARCIOLA C R, PIETROCOLA G.Fibronectin and its role in human infective diseases[J].Cells, 2019, 8(12):1516.
[3] MOHAMED G B, SAED M A, ABDELHAKEEM A A,et al. Predictive value of copeptin as a severity markerof community-acquired pneumonia[J]. ElectronicPhysician, 2017, 9(7): 4880-4885.
[4] CAO Changlin,GU Jingxian,ZHANG Jingyao.Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosisof infectious diseases[J]. Frontiers of Medicine, 2017,11(2):169-177.
[5] 中国医师协会急诊医师分会.中国急诊重症肺炎临床实践专家共识[J].中国急救医学,2016,36(2):97-107.Chinese College of Emergency Physicans. Expertconsensus on clinical practice of acute severepneumonia in China[J]. Chinese Journal of CriticalCare Medicine,2016,36(2):91-107.
[6] 马素霞,张红,张丽英,等.脓毒症患者血清脑钠肽水平与APACHE Ⅱ评分的研究[J]. 山西医科大学学报,2014,45(5):401-403.MA Suxia, ZHANG Hong, ZHANG Liying ,et al. Therelationship between brain natriuretic peptide and acutephysiology and chronic health evaluation Ⅱ (APACHEⅡ ) in patients with sepsis [J]. Journal of ShanxiMedical University,2014,45(5):401-403.
[7] LEONI D, RELLO J. Severe community-acquiredpneumonia: optimal management[J]. Current Opinionin Infectious Diseases, 2017, 30(2): 240-247.
[8] LI Yan ,MIAO Liyun ,YU Min ,et al. Alpha 1-antitrypsinpromotes lung adenocarcinoma metastasis throughupregulating fibronectin expression [J]. InternationalJournal of Oncology,2017,50(6):1955-1964.
[9] RAYMOND B B A, TURNBULL L, JENKINS C, etal. Mycoplasma hyopneumoniae resides intracellularlywithin porcine epithelial cells[J]. Scientific Reports,2018, 8(1): 17697.
[10] DIGIACOMO G, TUSA I, BACCI M, et al. Fibronectininduces macrophage migration through a SFK-FAK/CSF-1R pathway[J]. Cell Adhesion & Migration, 2017,11(4): 327-337.
[11] MONTI M, IOMMELLI F, DE ROSA V, et al. Integrindependentcell adhesion to neutrophil extracellular trapsthrough engagement of fibronectin in neutrophil-likecells[J]. PLoS One, 2017, 12(2): e0171362.
[12] JUN H K, JUNG Y J, CHOI B K. Inflammasomeactivators induce fibronectin expression and release inmacrophages[J]. Cellular Microbiology, 2017, 19(5):12695.
[13] MANNE K, NARAYANA S, CHATTOPADHYAYD. Crystal structure of the N-terminal domain of thefibronectin-binding protein PavA from Streptococcuspneumoniae[J]. Acta Crystallographica Section F:Structural Biology Communications, 2019, 75(10):657-662.
[14] 吴海荣,吴锡平,高树芹.早期监测血浆纤维结合蛋白水平对重症肺炎患者病情严重程度及预后的影响[J]. 中国急救医学,2018,38(2):149-151.WU Hairong,WU Xiping, GAO Shuqin. The value ofearly fibronectin on predicting the severity and prognosisin patients with severe pneumonia [J]. ChineseJournal of Critical Care Medicine,2018,38(2):149-151.
[15] ABDEL-FATTAH M, MELIGY B, EL-SAYED R, etal. Serum copeptin level as a predictor of outcome inpneumonia[J]. Indian Pediatrics, 2015, 52(9): 807-808.
[16] YILMAN M, ERENLER A K, BAYDIN A. Copeptin:a diagnostic factor for critical patients[J]. EuropeanReview for Medical and Pharmacological Sciences,2015, 19(16): 3030-3036.
[17] WINTHER J A, BRYNILDSEN J, H?ISETH A D, etal. Prognostic and diagnostic significance of copeptinin acute exacerbation of chronic obstructive pulmonarydisease and acute heart failure: data from the ACE 2study[J]. Respiratory Research, 2017, 18(1): 184.
[18] SU Longxiang, LIU Dan, CHAI Wenzhao, et al. Roleof sTREM-1 in predicting mortality of infection: asystematic review and meta-analysis[J]. BMJ Open,2016, 6(5): e010314.
[19] HU Chengping, JIANG Juan, LI Zhen, et al. Expressionpattern of soluble triggering receptor expressed onmyeloid cells-1 in mice with Acinetobacter baumanniicolonization and infection in the lung[J]. Journal ofThoracic Disease, 2018, 10(3): 1614-1621.
[20] LI Chunxiang, ZHU Limin, GONG Xiaolei , et al.Soluble triggering receptor expressed on myeloidcells-1 as a useful biomarker for diagnosing ventilatorassociatedpneumonia after congenital cardiac surgeryin children[J]. Experimental and Therapeutic Medicine,2019, 17(1): 147-152.
[21] 李瑞萍, 宋伟. 血浆sTREM-1,sFLT-1 及APACHEⅡ评分对重症肺炎患者预后评估价值[J]. 国际呼吸杂志,2018,38(13):968-971.LI Ruiping,SONG Wei. Prognostic evaluation valueof plasma sTREM-1, sFLT-1 and APACHE Ⅱ scorein patients with severe pneumonia [J]. InternationalJournal of Respiration,2018,38(13):968-971.
[22] 李明霞,洪智峰,陈伟健,等.可溶性髓样细胞触发受体1 与可溶性血红蛋白清道夫受体诊断呼吸机相关性肺炎的价值[J].实用临床医学,2018,19(2):19-21, 25.LI Mingxia,HONG Zhifeng,CHEN Weijian,et al. Valueof soluble myeloid cell triggering receptor 1 and solublehemoglobin scavenger receptor in the diagnosis ofventilator-associated pneumonia [J]. Practical ClinicalMedicine,2018,19(2):19-21,25.

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备注/Memo

备注/Memo:
基金项目:海南省自然科学基金(818QN318)。
作者简介:符征高(1987-),男,本科,主治医师,研究方向:呼吸疾病的诊断和治疗,E-mail:3535119126@qq .com。
更新日期/Last Update: 1900-01-01