[1]符征高,陈 钰,梁 勇,等.重症肺炎患者血清Fn,Copeptin及sTREM-1水平变化及临床意义[J].现代检验医学杂志,2021,36(04):111-115.[doi:10.3969/j.issn.1671-7414.2021.04.023]
 FU Zheng-gao,CHEN Yu,LIANG Yong,et al.Changes and Clinical Significance of Serum Levels of Fn, Copeptin andsTREM-1 in Patients with Severe Pneumonia[J].Journal of Modern Laboratory Medicine,2021,36(04):111-115.[doi:10.3969/j.issn.1671-7414.2021.04.023]
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重症肺炎患者血清Fn,Copeptin及sTREM-1水平变化及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
111-115
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Changes and Clinical Significance of Serum Levels of Fn, Copeptin andsTREM-1 in Patients with Severe Pneumonia
文章编号:
1671-7414(2021)04-111-05
作者:
符征高陈 钰梁 勇许俊旭吴挺实郝金香
(海口市第三人民医院,海口 571100)
Author(s):
FU Zheng-gao CHEN Yu LIANG Yong XU Jun-xu WU Ting-shi YU Jin-xiang
(the Third People’s Hospital of Haikou City, Haikou 571100,China)
关键词:
重症肺炎纤维结合蛋白和肽素可溶性髓样细胞触发受体1
分类号:
R563.1;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.04.023
文献标志码:
A
摘要:
目的 观察重症肺炎患者血清纤维结合蛋白(Fn)、和肽素(Copeptin)、可溶性髓样细胞触发受体1(sTREM-1)水平变化,分析其与病情严重程度以及预后的关系。方法 选择122 例社区获得性重症肺炎患者(肺炎组),根据APACHE Ⅱ将患者分为低危组(< 10 分,45 例),中危组(10~20 分,43 例)和高危组(> 20分,34 例),根据28 天内生存情况分为死亡组(31 例)和存活组(91 例),另选择92 例健康志愿者为对照组。检测血清Fn,Copeptin 和sTREM-1 水平,分析其与重症肺炎患者病情和预后的关系。结果 肺炎组血清Fn 水平为177.26±31.94mg/L,低于对照组231.26±21.54mg/L(t=8.751,P < 0.001),血清Copeptin 和sTREM-1 水平分别为70.45±0.47pmol/L,169.26±31.94pg/ml, 高于对照组的55.45±7.06pmol/L 和34.18±9.54pg/ml(t=12.637,39.235,P < 0.001)。血清Copeptin 和sTREM-1 水平在低危组、中危组、高危组依次升高,Fn 水平依次降低,各组间差异均有统计学意义(均P < 0.05)。治疗后肺炎患者血清Fn 水平升高(t=8.977,P < 0.05),Copeptin 和sTREM-1 水平降低(t=20.941,31.982,均P < 0.05)。死亡组血清Fn 和sTREM-1 水平低于存活组(t=6.377,8.285,均P < 0.001),血清Copeptin 水平高于存活组(t=7.845,P < 0.001)。血清Fn 水平与CPIS 评分,APACHE Ⅱ评分呈负相关(rs=-0.569,-0.632,均P < 0.001),与OI 指数呈正相关(r=0.496,P < 0.01)。血清Copeptin,sTREM-1 水平与CPIS 评分,APACHE Ⅱ评分呈正相关(rs=0.573,0.603,0.517 和0.529,均P < 0.001),与OI 指数呈负相关(r=-0.437,-0.506,均P < 0.01)。低水平Fn(OR=0.768,95%CI:0.617~0.806),高水平Copeptin(OR=1.650,95%CI:1.523~1.769),高水平sTREM-1(OR=1.602,95%CI:1.543 ~ 1.732)是重症肺炎患者死亡的危险因素(P< 0.01)。结论 重症肺炎患者血清Fn 水平降低,Copeptin,sTREM-1 水平升高,低水平Fn,高水平Copeptin 和sTREM-1 与患者病情加重和不良预后有关。

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备注/Memo

备注/Memo:
基金项目:海南省自然科学基金(818QN318)。
作者简介:符征高(1987-),男,本科,主治医师,研究方向:呼吸疾病的诊断和治疗,E-mail:3535119126@qq .com。
更新日期/Last Update: 1900-01-01