[1]赵大龙,田金灵.创伤性颅脑损伤患者血清 miR-422a，miR-212-5p表达水平与病情和预后的相关性研究[J].现代检验医学杂志,2022,37(01):67-71.[doi:10.3969/j.issn.1671-7414.2022.01.014]
　ZHAO Da-long,TIAN Jin-ling.Correlation of miR-422a and miR-212-5p Expression Levels with Disease and Prognosis in Patients with Traumatic Brain Injury[J].Journal of Modern Laboratory Medicine,2022,37(01):67-71.[doi:10.3969/j.issn.1671-7414.2022.01.014]
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创伤性颅脑损伤患者血清 miR-422a，miR-212-5p表达水平与病情和预后的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年01期
页码:
67-71
栏目:
论　著
出版日期:
2022-01-15

文章信息/Info

Title:
Correlation of miR-422a and miR-212-5p Expression Levels with Disease and Prognosis in Patients with Traumatic Brain Injury
文章编号:
1671-7414（2022）01-067-05
作者:
赵大龙; 田金灵
（菏泽市中医医院医学检验科，山东菏泽 274000）
Author(s):
ZHAO Da-long; TIAN Jin-ling
（Department of Laboratory Medicine, Hospital of Traditional Chinese Medicine of Heze City, Shandong Heze 274000，China）
关键词:
微小核糖核酸 -422a; 微小核糖核酸 -212-5p; 创伤性脑损伤
分类号:
R651.15；R392.11
DOI:
10.3969/j.issn.1671-7414.2022.01.014
文献标志码:
A
摘要:
目的　探讨创伤性颅脑损伤患者血清 miR-422a，miR-212-5p表达与病情和预后的相关性，分析 miR-422a，miR-212-5p诊断创伤性脑损伤患者预后的价值。方法　连续性选择 2018年 4月～ 2020年 6月山东省菏泽市中医院收治的 173例创伤性颅脑损伤患者（创伤组）和同期 125例志愿者（对照组）。根据格拉斯哥昏迷量表（ GCS）评分将创伤组患者分为轻度组（ GCS评分 13~15分，57例），中度组（ GCS评分 9~12分，63例）和重度组（ GCS评分 3~8分，53例），追踪临床结局，根据格拉斯哥预后量表（ GOS）评分将患者分为预后不良组（ GOS评分 1~3分，62例）和预后良好组（ GOS评分 4~5分，111例）。检测所有受试者血清 miR-422a，miR-212-5p表达，比较组间差异，分析 miR-422a，miR-212-5p与创伤性颅脑损伤患者预后的关系以及 miR-422a，miR-212-5p预测患者预后的价值。结果　创伤组血清 miR-422a表达高于对照组（3.02±1.02 vs 0.95±0.21），miR-212-5p表达低于对照组（ 1.03±0.28 vs 2.85±0.61），差异均有统计学意义（ t=22.340，
Abstract:
Objective　To investigate the correlation between the expression of serum miR-422a and miR-212-5p in patientswith traumatic brain injury with the condition and prognosis, and analyze the diagnostic value of miR-422a and miR-212-5p inthe prognosis of patients with traumatic brain injury. Methods　A total of 173 patients with traumatic craniocerebral injury(trauma group) and 125 volunteers (control group) admitted to Heze Hospital of Traditional Chinese Medicine of ShandongProvince from April 2018 to June 2020 were successively selected. According to the Glasgow Coma Scale (GCS) score, thepatients in the trauma group were divided into mild group (GCS score 13~15, 57 cases), moderate group (GCS score 9~12, 63cases) and severe group (GCS score 3~8, 53 cases). The clinical outcome was tracked，according to Glasgow Outcome Scale(GOS), the patients were divided into poor prognosis group (GOS score 1~3, 62 cases) and good prognosis group (GOS score4~5, 111 cases). The expression of serum miR-422a and miR-212-5p of all subjects was detected, and the differences betweengroups were compared to analyze the relationship between miR-422a and miR-212-5p and the prognosis of patients withtraumatic brain injury, as well as the value of miR-422a and miR-212-5p in predicting the prognosis of patients. Results　Theexpression of miR-422a in the trauma group was higher than that in the control group (3.02±1.02 vs 0.95±0.21), and theexpression of miR-212-5p in the trauma group was lower than that in the control group (1.03±0.28 vs 2.85±0.61）, thedifference sentences were statistically significant（t =22.340,34.544, all P< 0.05). The expression of miR-422a in the severegroup was higher than that in the moderate and mild groups (4.01±0.13 vs 2.92±0.66, 2.21±0.12; t =11.824，75.516，all P< 0.05),and the expression of miR-212-5p was lower than that in the moderate and mild groups (0.84±0.06 vs 0.97±0.25, 1.27±0.04; t=3.695，44.512，P < 0.05). The expression of miR-422a in the poor prognosis group was higher than that in the good prognosisgroup (4.05±0.11 vs 2.44±0.31, t =22.340, P < 0.05), and the expression of miR-212-5p was lower than that in the goodprognosis group (0.83±0.06 vs 1.14±0.21，t =22.340, P < 0.05)， the difference sentences were statistically significant ,respectively. Low GCS score (OR=0.825, 95%CI: 0.721~0.945), high miR-422a expression (OR=1.394, 95%CI: 1.194~1.627),low miR-212-5p expression (OR=0.744, 95%CI: 0.667~0.831) was risk factors for poor prognosis in patients with traumaticbrain injury (P < 0.05). The area under the curve of combined miR-422a and miR-212-5p for predicting poor prognosis inpatients with traumatic brain injury was 0.907, which was higher than 0.797 and 0.775 of miR-422a and miR-212-5p alone(Z=2.412, 2.561，all P < 0.05). Conclusion　Overexpression of miR-422a and deletion of miR-212-5p were associated withseverity and poor prognosis of traumatic brain injury, and can be used as a potential biological indicator for prognosis prediction.

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备注/Memo

备注/Memo:
作者简介：赵大龙（1987-），男，本科，主管检验师，研究方向：医学检验，E-mail:5634148@qq.com。
更新日期/Last Update: 1900-01-01