[1]谭　雍,严　敏,程　珍,等.433例肺血栓栓塞症患者血液 C-反应蛋白、抗凝血酶和纤维蛋白原及血液学变化特点分析[J].现代检验医学杂志,2022,37(01):203-206.[doi:10.3969/j.issn.1671-7414.2022.01.042]
　TAN Yong,YAN Min,CHENG Zhen,et al.Analysis of Change Feature of CRP ,Antithrombin, Fibrinogen and Hematological Indexs in 433 Patients with PulmonaryThromboembolism[J].Journal of Modern Laboratory Medicine,2022,37(01):203-206.[doi:10.3969/j.issn.1671-7414.2022.01.042]
点击复制

433例肺血栓栓塞症患者血液 C-反应蛋白、抗凝血酶和纤维蛋白原及血液学变化特点分析()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年01期
页码:
203-206
栏目:
检验与临床
出版日期:
2022-01-15

文章信息/Info

Title:
Analysis of Change Feature of CRP ,Antithrombin, Fibrinogen and Hematological Indexs in 433 Patients with PulmonaryThromboembolism
文章编号:
1671-7414（2022）01-203-04
作者:
谭　雍; 严　敏; 程　珍; 潘湘涛
（苏州大学附属太仓医院，江苏太仓 215400）
Author(s):
TAN Yong;  YAN Min;  CHENG Zhen;  PAN Xiang-tao
（Taicang Hospital of Suzhou University，Jiangsu Taicang 215400，China）
关键词:
肺血栓栓塞症; C-反应蛋白; 抗凝血酶; 纤维蛋白原; D-二聚体; 血小板
分类号:
R563.5；R446.11
DOI:
10.3969/j.issn.1671-7414.2022.01.042
文献标志码:
A
摘要:
目的　研究肺血栓栓塞症（ pulmonary thromboembolism, PTE）患者的 C反应蛋白（ CRP）、抗凝血酶（ AT）和纤维蛋白原（ FB）等凝血指标和血液学变化特点及其与 PTE发生的关系。方法　选取 433例经螺旋 CT肺动脉造影（computed tomography pulmonary angiogrophy, CTPA）确诊的 PTE患者，对患者的临床特点、 CRP，AT，FB，血浆 D二聚体（ D-D）和血小板（ PLT）计数以及凝血指标进行综合分析，并探讨其相关的临床意义。结果　① PTE总发生率
Abstract:
Objective　To study the characteristics of coagulation indexes and hematological, changes such as C-reactiveprotein(CRP), antithrombin(AT) and fibrinogen(FB) in patients with pulmonary thromboembolism (PTE) and their relationshipwith PTE. Methods　The clinical characteristics, D-D, PLT counts, CRP, AT, and FB of 433 patients with PTE confirmed byCTPA were analyzed comprehensively, and the clinical significance was discussed. Results　① The total incidence of PTE was1.60‰(433/27 083), over 60 years old was the age of high incidence. ② D-D elevation was found in 412 cases(95.15%).PLTwere normal in 331 cases (76.44%), decreased in 53 cases (12.24%) and increased in 49 cases (11.31%); ③ CRP was increasedin 288 cases(75.99%) and normal in 91 cases(24.01%). ④ AT was decreased in 109 cases (25.17%) and FB was increased in102 cases (23.56%). There were no abnormal changes in other coagulation indexes. ⑤ CRP was positively correlated with PLTand FB (r=0.1026, t=2.0118, P<0.05 and r=0.0.536 0,t=12.296 3, P<0.01, respectively). ⑥ CRP was negatively correlatedwith AT(r=-0.200 5, t=4.010 0, P<0.01). Conclusion　Most patients with PTE had high expression of CRP and FB, and lowexpression of AT and CRP. AT and FB may be related to the occurrence of PTE.

参考文献/References:

[1] AHMED A B, KOSTER A, LANCE M, et al. Europeanguidelines on perioperative venous thromboembolismprophylaxis: Cardiovascular and thoracic surgery[J].European Journal of Anaesthesiology, 2018, 35(2): 84-89.
[2] AFSHARI A, AGENO W, AHMED A, et al. Europeanguidelines on perioperative venous thromboembolismprophylaxis: executive summary[J]. European Journalof Anaesthesiology, 2018, 35(2): 77-83.
[3] 恽佶例, 李小鹰. 静脉血栓栓塞症的病理流行病学研究状况[J]. 中华老年心脑血管病杂志, 2017,19(3):322-324.YUN Jil i,LI Xiaoying. Resear c h s t a t u s o fpathoepidemiology of venous thromboembolism[J].Chinese Journal of Geriatric Heart Brain and VesselDiseases,2017,19(7):322-324.
[4] 张伟, 王丁一, 崔娣, 等.2 型糖尿病合并肺栓塞12例尸检分析[J]．中国临床医生杂志，2015，43（6）：42-44.ZHANG Wei,WANG Dingyi,CUI Di,et al. Analysisof 12 case autopsy of type 2 diabetes mellituswith pulmonary embolism [J]. Chinese Journal forClinicians,2015,43(6):42-44.
[5] SHIMI M, ALLOUCHE M, BEN AHMED H, et al.Sudden death due to pulmonary embolism in northTunisia: 37 cases study[J]. Tunisie Medicale, 2014,92(10): 610-614.
[6] KARSY M， AZAB M A，HARPER J，et al.Evaluation of a D-Dimer protocol for detection ofvenous thromboembolism[J]. World Neurosurgery,2020, 133 : e774-e783.
[7] LIPPI G, FAVALORO E J, MONTAGNANA M, etal. C-reactive protein and venous thromboembolism:causal or casual association[J]. Clinical Chemistry andLaboratory Medicine, 2010, 48(12): 1693-1701.
[8] TAMAKI H, KHASNIS A. Venous thromboembolismin systemic autoimmune diseases: A narrative reviewwith emphasis on primary systemic vasculitides[J].Vascular Medicine (London, England), 2015, 20(4):369-376.
[9] FALANGA A, MARCHETTI M . Thrombosis inmyeloproliferative neoplasms[J]. Semin ThrombHemost, 2014,40(3):348-358.
[10] MUKUBO Y, KAWAMATA M. Perioperativehypercoagulability in patients with rheumatoid arthritis:Sonoclot study[J]. Journal of Anesthesia, 2004, 18(1): 62-64.
[11] ESMON C T. Inflammation and thrombosis[J].Journalof Thrombosis and Haomostasis.2003,1（7）:1343-1348.
[12] ZHENG Nengneng, SHI Xinping, CHEN Xiongwei,et al. Associations between inflammatory markers,hemostatic markers, and microvascular complicationsin 182 Chinese patients with type 2 diabetes mellitus[J].Laboratory Medicine, 2015, 46(3) : 214-220.
[13] 张之南, 郝玉书, 赵永强, 等. 血液病学 [M].2 版. 北京: 人民卫生出版社,2013:1440-1445.ZHANG Zhinan, HE Yushu, ZHAO Yongqiang, et al.Hematology[M]. 2th Ed.Beijing: People’s MedicalPublishing House,2013:1440-1445.
[14] 严敏，程旭，陆晔，等．肿瘤患者不同C 反应蛋白水平与IL-6 及贫血的关系[J]. 中国继续医学教育，2018, 10(34):76-78．YAN Min,CHENG Xu,LU Ye,et al. The relationship ofexpression level of C-reactive protein with serum IL-6and anemia in tumor patients [J]. China ContinuingMedical Education,2018,10(34):76-78.
[15] CHENG Zhen, YAN Min, LU Ye, et al. Expression ofserum BMP6 and hepcidin in cancer-related anemia[J].Hematology (Amsterdam, Netherlands), 2020, 25(1):134-138.

相似文献/References:

[1]周玉宝a,陈芦斌b,刘芳a,等.腹腔镜与ERCP手术后血清CRP和PCT检测比较分析[J].现代检验医学杂志,2015,30(05):4.[doi:10.3969/j.issn.1671-7414.2015.05.002]
　ZHOU Yu-baoa,CHEN Lu-binb,LIU Fanga,et al.Comparative Analysis of Serum CRP and PCT Detection after ERCP and Laparoscopic Operation[J].Journal of Modern Laboratory Medicine,2015,30(01):4.[doi:10.3969/j.issn.1671-7414.2015.05.002]
[2]侯 毅,陈东博,陈花莲.血浆CRP,D-D水平检测对急性血栓性肺栓塞危险分层的预测价值[J].现代检验医学杂志,2018,33(06):107.[doi:10.3969/j.issn.1671-7414.2018.06.028]
　HOU Yi,CHEN Dong-bo,CHEN Hua-lian.Predictive Value in Risk Stratification of Plasma CRP and D-D Levels for Patients with Acute Pulmonary Embolism[J].Journal of Modern Laboratory Medicine,2018,33(01):107.[doi:10.3969/j.issn.1671-7414.2018.06.028]
[3]谢正媛,陈涓涓,祖维磊,等.日本积水公司血浆全程C-反应蛋白胶乳免疫比浊法最低检测限和功能灵敏度的确认[J].现代检验医学杂志,2019,34(03):118.[doi:10.3969/j.issn.1671-7414.2019.03.029]
　XIE Zheng-yuan,CHEN Juan-juan,ZU Wei-lei,et al.Confirmation of the Limit of Detection and Functional Sensitivityfor the Nanopia CRP Reagent of Sekisui Medical Technology[J].Journal of Modern Laboratory Medicine,2019,34(01):118.[doi:10.3969/j.issn.1671-7414.2019.03.029]
[4]高　伟,席　锐,李　涛.血清C-反应蛋白和内皮素水平检测与急性胆囊炎临床分级的相关性分析[J].现代检验医学杂志,2021,36(02):144.[doi:doi:10.3969/j.issn.1671-7414.2021.02.034]
　GAO Wei,XI Rui,LI Tao.Correlation Analysis of Serum C-reactive Protein and Endothelin Levels with Clinical Grade of Acute Cholecystitis[J].Journal of Modern Laboratory Medicine,2021,36(01):144.[doi:doi:10.3969/j.issn.1671-7414.2021.02.034]
[5]段 玮,刘兴晖,李廷俊,等.基于血液炎症相关指标建立儿童复杂性阑尾炎的预测模型及验证[J].现代检验医学杂志,2023,38(02):155.[doi:10.3969/j.issn.1671-7414.2023.02.029 ]
　DUAN Wei,LIU Xing-hui,LI Ting-jun,et al.Establishment of Predictive Models and Verification Based on Related Inflammatory Factors in Blood of Complex Appendicitis in Children[J].Journal of Modern Laboratory Medicine,2023,38(01):155.[doi:10.3969/j.issn.1671-7414.2023.02.029 ]

备注/Memo

备注/Memo:
作者简介：谭雍（1995-），女，苏州大学2019 级硕士研究生，主要从事血液病的基础与临床研究。
通讯作者：潘湘涛，男，主任医师，E-mail:panxiangtao@csco.ac.cn。
更新日期/Last Update: 1900-01-01