[1]林燕玲,王　瑛,张　敏,等.上皮性卵巢癌组织中miR-506-3p及miR-532-5p的表达与临床病理特征及预后的相关研究[J].现代检验医学杂志,2022,37(03):83-86.[doi:10.3969/j.issn.1671-7414.2022.03.017]
　LIN Yan-ling,WANG Ying,ZHANG Min,et al.Correlation between the Expression of miR-506-3p and miR-532-5p and Clinicopathological Features and Prognosis in Epithelial Ovarian Cancer[J].Journal of Modern Laboratory Medicine,2022,37(03):83-86.[doi:10.3969/j.issn.1671-7414.2022.03.017]
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上皮性卵巢癌组织中miR-506-3p及miR-532-5p的表达与临床病理特征及预后的相关研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年03期
页码:
83-86
栏目:
论　著
出版日期:
2022-05-15

文章信息/Info

Title:
Correlation between the Expression of miR-506-3p and miR-532-5p and Clinicopathological Features and Prognosis in Epithelial Ovarian Cancer
文章编号:
1671-7414（2022）03-083-04
作者:
林燕玲; 王　瑛; 张　敏; 康　灵; 邢维珍; 黎先萍
（上海儿童医学中心三亚市妇女儿童医院，海南三亚 572000）
Author(s):
LIN Yan-ling;  WANG Ying;  ZHANG Min;  KANG Ling;  XING Wei-zhen;  LI Xian-ping
（Sanya Women and Children’s Hospital Managed by Shanghai Children’s Medical Center, Hainan Sanya 572000，China）
关键词:
上皮性卵巢癌; 微小核糖核酸-506-3p; 微小核糖核酸-532-5p
分类号:
R737.31；R730.43
DOI:
10.3969/j.issn.1671-7414.2022.03.017
文献标志码:
A
摘要:
目的　探讨 miR-506-3p及 miR-532-5p在上皮性卵巢癌（ epithelial ovarian cancer，EOC）组织中的表达及其对预后预测的意义。方法　选取 2017年 1月～ 2019年 12月三亚市妇女儿童医院和三亚中心医院收治的 118例 EOC患者。检测 EOC组织及正常组织中 miR-506-3p及 miR-532-5p表达水平。应用单因素及多因素 COX回归模型分析 EOC患者预后不良的危险因素。结果　EOC组织 miR-506-3p（0.31±0.05）及 miR-532-5p（0.24±0.03）表达水平低于正常组织（ 1.16±0.42，1.48±0.51），差异有统计学意义（ t=13.582，16.217，均 P<0.001）。Kaplan-Meier生存分析显示， miR-506-3p及 miR-532-5p低表达与 EOC患者生存期短有关（ P<0.001）。多因素分析显示，淋巴结转移 [HR（95%CI） =1.840（1.137～ 4.105）]，腹膜转移 [HR（95%CI）=2.974（2.106～ 6.113）]，miR-506-3p＜ 0.45[HR（95%CI）=1.902（1.217～ 4.533）]及 miR-532-5p＜ 0.32[HR（95%CI）=2.506（1.582～ 4.905）]是影响 EOC患者预后不良的独立危险因素（均 P<0.05）。结论　 miR-506-3p及 miR-532-5p在 EOC组织中明显下调，其低表达的 EOC患者生存期较短，对 EOC患者预后预测具有较好的价值。
Abstract:
Objective　To investigate the expression of miR-506-3p and miR-532-5p in epithelial ovarian cancer (EOC) and its prognostic significance. Methods　The 118 patients with EOC admitted to Sanya Woman and Children’s Hospital and Sanya Central Hospital from January 2017 to December 2019 were selected. The expression levels of miR-506-3p and miR- 532-5p in EOC and normal tissues were detected. Univariate and multivariate COX regression models were used to analyze the risk factors of poor prognosis in EOC patients. Results　The expression level of miR-506-3p (0.31±0.05 ) and miR-532- 5p (0.24±0.03 ) in EOC were lower than that in normal tissues(1.16±0.42，1.48±0.51 )，the differences were statistically significant (t=13.582, 16.217, all P<0.001). Kaplan-Meier survival analysis showed that low expression of miR-506-3p and miR- 532-5p were associated with short survival of EOC patients (P<0.001). Multivariate Cox regression analysis showed that lymph node metastasis[HR（95%CI）=1.840（1.137 ～ 4.105）], peritoneal metastasis[HR（95%CI）=2.974（2.106 ～ 6.113）], miR-506-3p<0.45 [HR（95%CI）=1.902（1.217 ～ 4.533）]and miR-532-5p<0.32[HR（95%CI）=2.506（1.582 ～ 4.905）] were independent risk factors for poor prognosis of EOC patients (all P<0.05). Conclusion　miR-506-3p and miR-532-5p were significantly down-regulated in EOC tissues, and the survival time of EOC patients with low expression of miR-506-3p was shorter, which had a good value for predicting the prognosis of EOC patients.

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备注/Memo

备注/Memo:
基金项目：海南省临床医学中心建设资助。
作者简介：林燕玲（1984-）, 女，本科，主治医师，主要从事临床妇产科疾病研究，E-mail: lyl_841220@163.com。
更新日期/Last Update: 1900-01-01