[1]吴晓康a,张 妮a,尹佳锋a,等.西安地区健康体检女性HPV 感染状况及基因型别分析[J].现代检验医学杂志,2022,37(04):139-142.[doi:10.3969/j.issn.1671-7414.2022.04.027]
　WU Xiao-kanga,ZHANG Nia,YIN Jia-fenga,et al.Analysis of HPV Infection Status and Genotype in Women Undergoing Physical Examination in Xi’an[J].Journal of Modern Laboratory Medicine,2022,37(04):139-142.[doi:10.3969/j.issn.1671-7414.2022.04.027]
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西安地区健康体检女性HPV 感染状况及基因型别分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年04期
页码:
139-142
栏目:
论著
出版日期:
2022-07-15

文章信息/Info

Title:
Analysis of HPV Infection Status and Genotype in Women Undergoing Physical Examination in Xi’an
文章编号:
1671-7414（2022）04-139-04
作者:
吴晓康a; 张 妮a; 尹佳锋a; 刘海龙a; 靳 莉a; 吴晓玲b; 李妙羡a; 耿 燕a
西安交通大学第二附属医院a. 检验科；b. 妇产科，西安710004
Author(s):
WU Xiao-kanga;  ZHANG Nia;  YIN Jia-fenga; LIU Hai-longa;  JIN Lia;  WU Xiao-lingb;  LI Miao-xiana;  GENG Yana
a.Department of Clinical Laboratory；b.Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
关键词:
人乳头瘤病毒（HPV）; 感染率; 基因分型
分类号:
R373.9；R446.7
DOI:
10.3969/j.issn.1671-7414.2022.04.027
文献标志码:
A
摘要:
目的 分析西安地区女性人乳头瘤病毒（human papilloma virus，HPV）感染状况及基因型的分布情况，为其防治提供依据。方法 选择2019 年4 月～ 2021 年12 月在西安交通大学第二附属医院健康体检的10 772 例女性人群为研究对象，应用PCR-反向杂交法对受检者宫颈脱落细胞样本进行28 种HPV 亚型检测，并将该研究结果与省内及国内其他地区报道结果进行比较分析。结果 检测的10 772 例样本中，有952 例HPV 阳性，感染率为8.84%；共检出27 种HPV 亚型，感染例次前四位的基因型别依次为HPV52，HPV53，HPV16 和HPV42；在HPV 感染类型中，单一型感染最多，共769 例，占比80.78%；各年龄段中，<25 岁和54 ～ <64 岁年龄段女性 HPV 感染率较高，各年龄组HPV 基因型别以高危型别为主，除<25 岁组（χ2=5.17，P=0.075）外，其他5 个年龄组高危型别感染例次与中危型、低危型别感染例次的差异均有统计学意义（χ2=88.60， 98.41，77.01，37.71，8.76，均P<0.05）；该研究结果与省内及国内其他地区报道的结果比较发现，国内女性HPV 感染均以单一型感染、高危基因型别为主，而在HPV 感染率、主要基因型别及高发年龄段上，结果有所不同。结论 西安地区女性人群以高危型HPV 感染为主，其中单一感染最多，青年和中老年女性群体HPV 感染率相对较高。及时了解该地区HPV 感染流行状况，做好HPV 筛查工作，对于女性宫颈癌的预防和治疗具有重要意义。
Abstract:
Objective To analyze the infection status and genotype distribution of female human papillomavirus (HPV) in Xi’an, and to provide evidence for its prevention and treatment. Methods A total of 10 772 women undergoing physical examination in the Second Affiliated Hospital of Xi’an Jiaotong University from April 2019 to December 2021 were selected as the subjects, PCR-reverse hybridization was used to detect 28 kinds of HPV subtypes in cervical exfoliated cells,and the results of this study were compared and analyzed with those reported whithin the province and other areas in China. Results Of 10 772 samples tested, 952 were HPV-positive, with an infection rate of 8.84%. A total of 27 types of HPV subtypes were detected. The top four genotypes were HPV52, HPV53,HPV16 and HPV42，single type infection was the most common among the types of HPV infection , with 769 cases, accounting for 80.78% of the total number of infections; among all age groups, HPV infection rate was higher in patients younger than 25 years and patients aged 54 to 64 years or younger than 64 years.HPV genotypes were mainly high-risk,except for the group younger than 25 years old(χ2=5.17, P=0.075), there were significant differences in the number of high-risk cases and that of medium-risk and low-risk cases in the other five age groups (χ2=88.60, 98.41, 77.01, 37.71, 8.76，all P<0.05). The results of this study were compared with those reported whithin the province and other regions of China, and it was found that HPV infection of domestic women was dominated by single infection and high-risk genotypes. However, the results of this study were different in HPV infection rate, main genotypes and age groups of high incidence. Conclusion The women in Xi’an were mainly infected with high-risk HPV, and single infection was the most common. HPV infection rate was relatively high in young and middle-aged women. It is of great significance for the prevention and treatment of cervical cancer to timely understand the epidemic situation of HPV infection in this area and to do well in HPV screening.

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备注/Memo

备注/Memo:
基金项目：中央高校基本科研业务费专项资金资助（xjj2015151）。
作者简介：吴晓康（1977-），男，研究生，副主任技师，主要从事感染性疾病分子诊断，E-mail：wxk111506@sohu.com。
通讯作者：耿燕（1967-），女，硕士生导师，主任技师，主要从事感染性疾病诊断。
更新日期/Last Update: 1900-01-01