[1]李 敏,陈 霞,何 偲,等.缺血性心力衰竭患者血清miR-34 表达水平与心室重构和预后的相关性分析[J].现代检验医学杂志,2023,38(04):67-71.[doi:10.3969/j.issn.1671-7414.2023.04.012]
　LI Min,CHEN Xia,HE Si,et al.Correlation between Serum miR-34 Expression and Ventricular Remodeling and Prognosis in Patients with Ischemic Heart Failure[J].Journal of Modern Laboratory Medicine,2023,38(04):67-71.[doi:10.3969/j.issn.1671-7414.2023.04.012]
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缺血性心力衰竭患者血清miR-34 表达水平与心室重构和预后的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年04期
页码:
67-71
栏目:
论著
出版日期:
2023-07-15

文章信息/Info

Title:
Correlation between Serum miR-34 Expression and Ventricular Remodeling and Prognosis in Patients with Ischemic Heart Failure
文章编号:
1671-7414（2023）04-067-05
作者:
李 敏1; 陈 霞1; 何 偲1; 李华华2
（1. 武汉亚洲心脏病医院，武汉 430022；2. 广西壮族自治区贺州市人民医院，广西贺州 542899）
Author(s):
LI Min1;  CHEN Xia1;  HE Si1;  LI Huahua2
（1.Wuhan Asian Heart Hospital, Wuhan 430022, China; 2.Guangxi Hezhou People’s Hospital, Guangxi Hezhou 542899, China）
关键词:
缺血性心力衰竭; 心室重构; 微小核糖核酸-34
分类号:
R541.6；R392.11
DOI:
10.3969/j.issn.1671-7414.2023.04.012
文献标志码:
A
摘要:
目的　检测缺血性心力衰竭（ischemic heart failure, IHF）患者血清微小核糖核酸（miR）-34 水平，分析其与IHF 患者心室重构（VR）及预后的相关性。方法　选择2019 年8 月～ 2021 年8 月武汉亚洲心脏病医院收治的80 例IHF 患者，入院时采用实时定量PCR 法测定血清miR-34 表达，对比不同临床特征的IHF 患者血清miR-34 表达状况。并分析血清miR-34 与IHF 患者VR 及预后的相关性。结果　80 例IHF 患者血清miR-34 水平为3.64±1.13；发生VR，预后不良的IHF 患者血清miR-34 水平高于未发生VR，预后良好的患者，差异均有统计学意义（t=7.630，4.492，均P＜ 0.05）；经点二列相关性分析结果显示，IHF 患者血清miR-34 与发生VR，预后不良呈正相关（r=33.967，16.193，均P ＜ 0.05）；经Logisitic 回归分析，结果显示，高血清miR-34 水平是IHF 患者发生VR，预后不良的危险因素（OR=4.437，3.526，均P ＜ 0.05）。结论　血清miR-34 水平与IHF 患者发生VR 密切相关，miR-34 高表达可增加患者不良预后风险。
Abstract:
Objective　To detect the serum micro ribonucleic acid (miR) -34 level in patients with ischemic heart failure (IHF) and analyze its correlation with ventricular remodeling (VR) and prognosis in patients with IHF. Methods　A total of 80 patients with IHF who were admitted to Wuhan Asian Heart Hospital from August 2019 to August 2021 were selected. Serum miR- 34 expression was measured by real-time quantitative PCR at the time of admission. According to whether the patients had VR after 6 months’follow-up, they were divided into VR group and non-VR group. According to the prognosis of patients, they were divided into a good prognosis group and a bad prognosis group. The baseline data of each subgroup were compared with the serum miR-34 expression, and the correlation between serum miR-34 and VR and prognosis of patients with IHF was analyzed by binary logistic regression and COX regression models, respectively. Results　The serum level of miR-34 in 80 patients with IHF was 3.64±1.13. The serum miR-34 level of IHF patients with VR and poor prognosis was higher than that of patients without VR and with good prognosis (t=7.630，4.492，all P<0.05). The results of point-two-column correlation analysis show that, serum miR-34 in IHF patients was positively correlated with VR and poor prognosis (r=33.967, 16.193, all P< 0.05). Logisitic regression analysis showed that high serum miR-34 level was a risk factor for VR and poor prognosis in IHF patients (OR=4.437, 3.526, all P < 0.05). Conclusion　Serum miR-34 levels were closely related to the occurrence of VR in patients with IHF, and high expression of miR-34 may increase the risk of poor prognosis in patients.

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备注/Memo

备注/Memo:
作者简介：李敏（1988-），女，本科，主治医师，主研方向：冠心病、心血管危重症。
通讯作者：李华华（1989-），男，主治医师，E-mail：yufeiqun919@163.com。
更新日期/Last Update: 2023-07-15