[1]韩 岳,左积文,陈丽丽,等.蛛网膜下腔出血患者不同神经功能恢复结局之间microRNAs 表达差异的meta 分析[J].现代检验医学杂志,2023,38(04):131-138.[doi:10.3969/j.issn.1671-7414.2023.04.024]
　HAN Yue,ZUO Jiwen,CHEN Lili,et al.Meta-analysis of Differential microRNA Expression between Different Neurological Recovery Outcomes in Patients with Subarachnoid Hemorrhage[J].Journal of Modern Laboratory Medicine,2023,38(04):131-138.[doi:10.3969/j.issn.1671-7414.2023.04.024]
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蛛网膜下腔出血患者不同神经功能恢复结局之间microRNAs 表达差异的meta 分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年04期
页码:
131-138
栏目:
论著
出版日期:
2023-07-15

文章信息/Info

Title:
Meta-analysis of Differential microRNA Expression between Different Neurological Recovery Outcomes in Patients with Subarachnoid Hemorrhage
文章编号:
1671-7414（2023）04-131-08
作者:
韩 岳1; 左积文1; 陈丽丽1; 王 静2
（1. 正定县人民医院外三科，石家庄 050800；2. 石家庄市第四医院产二科，石家庄 050011）
Author(s):
HAN Yue1;  ZUO Jiwen1;  CHEN Lili1;  WANG Jing2
（1. the Third Department of Surgery，Zhengdingxian People’s Hospital, Shijiazhuang 050800, China;2. the Second Department of Obstetrics, the Fourth Hospital of Shijiazhuang, Shijiazhuang 050011, China）
关键词:
蛛网膜下腔出血; 微小核糖核酸; 神经功能; meta 分析
分类号:
R743.35；R446
DOI:
10.3969/j.issn.1671-7414.2023.04.024
文献标志码:
A
摘要:
目的　评价蛛网膜下腔出血（subarachnoid hemorrhage，SAH）患者不同神经功能恢复结局之间的微小核糖核酸（micro-ribonucleic acid，microRNA）表达差异，根据microRNA 的表达差异探讨影响神经功能恢复的潜在机制。方法　计算机检索英文数据库PubMed，EmBase，Cochrane library，以及中文数据库中国知网（China national knowledgeinfrastructure，CNKI）、万方数据知识服务平台、重庆维普中文科技期刊数据库（China Science and TechnologyJournal Database，CSTJ）、中国生物医学文献服务系统，并检索了基因表达数据库包括高通量基因表达数据库（GeneExpression Omnibus，GEO）以及芯片表达谱数据库（Array Express）。搜集SAH 患者中关于microRNA 表达水平与不同神经功能恢复结局相关的病例对照研究。检索时间为建库至2022 年8 月。采用均数差值（mean difference，MD）及其95% 置信区间（confidence interval，CI）对microRNA 表达结果进行合并。对差异表达microRNA 的靶基因进行富集分析。结果　最终纳入发表于2017 ～ 2022 年的6 项研究。纳入研究均采用改良Rankin 量表（modified Rankin Scale，mRS）对神经功能恢复结局进行评估。Meta 分析结果认为，miR-152-3p [MD=-0.31，95%CI（-0.50，-0.13），矫正后P =0.006]，miR-221-3p [MD=-0.26，95%CI（-0.40，-0.11），矫正后P=0.005]，miR-34a-5p [MD=-0.28，95%CI（-0.46，-0.11），矫正后P= 0.009] 在神经功能恢复良好患者的脑脊液中表达水平低于神经功能恢复不良患者，差异具有统计学意义。而miR-210-3p [MD=0.23，95%CI（0.10，0.37），矫正后P = 0.006] 和miR-193b-3p [MD=0.16，95%CI（0.12，0.20），矫正后P= 0.002] 在神经功能恢复良好患者的脑脊液或外周血中表达水平高于神经功能恢复不良患者，差异具有统计学意义。靶基因富集分析显示PI3K-AKT 信号通路与SAH 患者神经功能恢复结局相关。结论　SAH 患者不同神经功能恢复结局之间microRNA 表达差异具有统计学意义，microRNA 有望成为判定神经功能恢复结局的生物标志物。靶基因富集分析证实了PI3K-AKT 信号通路在SAH 患者神经功能恢复中的关键作用。
Abstract:
Objective　To evaluate differential micro-ribonucleic acid (microRNA) expression between different neurological function recovery outcomes in patients with subarachnoid hemorrhage (SAH) and to explore the potential mechanisms affecting neurological function recovery according to the differential microRNA expression. Methods　Literature databases including PubMed，EmBase，Cochrane library, China national knowledge infrastructure (CNKI), Wanfang data knowledge service platform, China Science and Technology Journal Database (CSTJ), SinoMed, and the gene expression databases, including Gene Expression Omnibus (GEO) and Arrary Express, were searched from inception to August 2022. Study reported the microRNA expression in SAH patients with different neurological outcome were included. The microRNA expression results were pooled using mean difference (MD) with its 95% confidence interval(CI), and the target genes of significantly expression microRNAs were selected for enrichment analysis. Results　Six studies published between 2017 and 2022 were finally included. The neurological outcomes were all assessed using the modified Rankin Scale (mRS). Meta-analysis showed miR-152-3p[MD=-0.31, 95%CI(-0.50, -0.13), adjusted P=0.006], miR-221-3p [MD= -0.26, 95%CI( -0.40, -0.11), adjusted P =0.005], and miR-34a- 5p[MD=-0.28, 95%CI( -0.46, -0.11), adjusted P = 0.009] were lower expressed in the cerebrospinal fluid of neurological good recovery patients than that of poor recovery patients with statistically significant. MiR-210-3p[MD=0.23, 95%CI(0.10, 0.37), adjusted P = 0.006] and miR-193b-3p[MD=0.16, 95%CI(0.12, 0.20), adjusted P = 0.002] were higher expressed in cerebrospinal fluid or serum of neurological good recovery patients than that of poor recovery patients with statistically significant. The enrichment analysis revealed that the PI3K-AKT signaling pathway was associated with neurological outcome after SAH. Conclusion　There were differences in microRNA expression between different neurological functional recovery outcomes in SAH patients and microRNA was expected to be a biomarker to determine the neurological recovery outcome. The enrichment analysis validated the key role of the PI3K-AKT signaling pathway in the neurological recovery of SAH patients.

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备注/Memo

备注/Memo:
作者简介：韩岳（1984-），男，本科，副主任医师，研究方向：神经外科学相关疾病，E-mail：hanyue8011@sohu.com。
更新日期/Last Update: 2023-07-15