[1]王巧祎,王宁宁,刘晴晴,等.EB 病毒BART miRNAs 在胃癌中的作用机制研究进展[J].现代检验医学杂志,2023,38(05):199-204.[doi:10.3969/j.issn.1671-7414.2023.05.038]
 WANG Qiaoyi,WANG Ningning,LIU Qingqing,et al.Research Progress on the Mechanism of Epstein-Barr Virus BART miRNAs in Gastric Cancer[J].Journal of Modern Laboratory Medicine,2023,38(05):199-204.[doi:10.3969/j.issn.1671-7414.2023.05.038]
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EB 病毒BART miRNAs 在胃癌中的作用机制研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年05期
页码:
199-204
栏目:
综述
出版日期:
2023-09-15

文章信息/Info

Title:
Research Progress on the Mechanism of Epstein-Barr Virus BART miRNAs in Gastric Cancer
文章编号:
1671-7414(2023)05-199-06
作者:
王巧祎1王宁宁12刘晴晴12成 军1
(1. 中国人民解放军联勤保障部队第九〇三医院检验科,杭州 310013;2. 蚌埠医学院检验医学院,安徽蚌埠 233000)
Author(s):
WANG Qiaoyi1 WANG Ningning12 LIU Qingqing12 CHENG Jun1
(1.Department of Clinical Laboratory, the 903rd Hospital of the People’s Liberation Army, Hangzhou 310013, China; 2 .School of Laboratory Medicine, Bengbu Medical College, Anhui Bengbu 233000, China)
关键词:
EB 病毒微小核糖核酸BamHI-A 右向转录本胃癌
分类号:
R735.2;R730.43
DOI:
10.3969/j.issn.1671-7414.2023.05.038
文献标志码:
A
摘要:
EB 病毒(Epstein-Barr virus,EBV)是一种普遍存在的人类疱疹病毒,与胃癌的发生发展密切相关。EBV也是第一个被发现编码微小核糖核酸(microRNAs,miRNAs)的人类病毒,编码25 种miRNA 前体,最终被加工成44 种成熟的miRNA。BamHI-A 右向转录本(BamHI-A region rightward transcript,BART) miRNA 包含其中的40 种miRNA,由BART 编码产生,主要通过靶向宿主基因和自身病毒基因,在胃癌的发生发展中发挥重要的调控作用。本文对BART miRNAs 在胃癌发生发展中的作用机制进行总结,为胃癌患者寻找潜在的治疗靶点提供新思路。
Abstract:
Epstein-Barr virus (EBV) is a universal human herpes virus, which is closely related to the occurrence and development of gastric cancer. EBV is also the first human virus found to encode microRNAs (miRNAs), encoding 25 miRNA precursors that are eventually processed into 44 mature miRNAs. BamHI-A region rightward transcript (BART) miRNA encoded by BART contains 40 miRNAs, which plays an important regulatory role in the occurrence and development of gastric cancer mainly by targeting host genes and its own viral genes. The purpose of this paper is to summarize the mechanism of BART miRNAs in the occurrence and development of gastric cancer, and to provide new ideas for seeking potential therapeutic targets for patients with gastric cancer.

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备注/Memo

备注/Memo:
作者简介:王巧祎(1997-),女,硕士,检验技师,研究方向:病毒致病机制,E-mail:wangqy9797@163.com。
通讯作者:成军(1967-),男,主任医师,研究方向:感染性疾病实验室诊断,E-mail:cj1171967@163.com。
更新日期/Last Update: 2023-09-15