[1]桂 秀,陶璃娜,乔 娟,等.精神分裂症患者血清P2X7R和CTGF水平表达与临床症状评分及认知功能的相关性研究[J].现代检验医学杂志,2024,39(01):61-66.[doi:10.3969/j.issn.1671-7414.2024.01.011]
　GUI Xiu,TAO Lina,QIAO Juan,et al.Correlation between the Expression of Serum P2X7R and CTGF Levels and Clinical Symptom Scores and Cognitive Function in Patients with Schizophrenia[J].Journal of Modern Laboratory Medicine,2024,39(01):61-66.[doi:10.3969/j.issn.1671-7414.2024.01.011]
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精神分裂症患者血清P2X7R和CTGF水平表达与临床症状评分及认知功能的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年01期
页码:
61-66
栏目:
论著
出版日期:
2024-01-15

文章信息/Info

Title:
Correlation between the Expression of Serum P2X7R and CTGF Levels and Clinical Symptom Scores and Cognitive Function in Patients with Schizophrenia
文章编号:
1671-7414（2024）01-061-06
作者:
桂 秀1; 陶璃娜1; 乔 娟1; 陈 芬2; 3; 4
（1. 武汉市武东医院精神重症一科，武汉 430000；2. 华中科技大学同济医学院附属协和医院心内科，武汉 430022；3. 生物靶向治疗研究湖北省重点实验室，武汉 430022；4. 心血管疾病免疫诊疗湖北省工程研究中心，武汉 430022）
Author(s):
GUI Xiu1;  TAO Lina1;  QIAO Juan1;  CHEN Fen 2; 3; 4
（1. Department of Mental Intensive Care, Wuhan Wudong Hospital, Wuhan 430000，China；2. Department of Cardiology, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; 3. Hubei Provincial Key Laboratory of Biotargeted Therapy Research, Wuhan 430022, China；4. Cardiovascular Disease Immunodiagnosis and Treatment Hubei Engineering Research Center, Wuhan 430022, China）
关键词:
精神分裂症; 嘌呤能离子通道型受体7; 结缔组织生长因子; 认知功能
分类号:
R749.3；R392.11
DOI:
10.3969/j.issn.1671-7414.2024.01.011
文献标志码:
A
摘要:
目的　探究血清嘌呤能离子通道型受体7(purinergic ligand-gated ion channel 7 receptor，P2X7R)、结缔组织生长因子(connective tissue growth factor，CTGF) 表达与精神分裂症患者认知功能、临床症状的相关性。方法　选取2021 年1 月～ 2023 年1 月在武汉市武东医院精神重症一科诊治的160 例精神分裂症患者作为观察组，及同期160 例健康体检志愿者作为对照组进行研究。根据阳性和阴性症状量表（positive and negative syndrome scale，PANSS）对患者精神临床症状（阳性和阴性症状、一般病理症状、附加症状）进行评估，将患者分为高分组（PANSS 总分≥ 70 分，n=72）和低分组（PANSS 总分<70 分，n=88）。利用精神分裂症认知功能成套测验共识版(MATRICS consensus cognitive battery，MCCB) 评估患者认知能力；采用酶联免疫吸附测定（ELISA）法检测血清P2X7R 和CTGF 水平；Spearman 法分析精神分裂症患者血清P2X7R 和CTGF 水平与PANSS 各项评分、MCCB 各项评分的相关性。结果　与对照组相比，观察组血清P2X7R（610.71±107.83ng/L vs 384.78±80.62ng/L），CTGF 水平（1.85±0.36μg/L vs 1.40±0.21μg/L）升高，差异有统计学意义（t=21.226，13.658，P<0.05）；观察组精神分裂症患者MCBB 各项评分均低于对照组，差异有统计学意义（t=14.845 ～ 24.862，均P<0.05）；高分组精神分裂症患者阳性症状评分（21.10±3.42 分）、阴性症状评分（23.37±5.03分）、一般病理症状评分（39.48±8.11 分）、附加症状评分（8.26±1.22 分）和PANSS 总分（92.21±12.50 分）均高于低分组（13.65±3.04 分，15.62±3.91 分，30.14±6.15 分，5.20±0.94 分，64.61±5.30 分），差异有统计学意义（t=14.576，10.964，8.280，17.915，18.764，均P<0.05）；高分组精神分裂症患者血清P2X7R，CTGF 水平高于低分组，差异有统计学意义（t=12.233，5.923，均P<0.05）；精神分裂症患者血清P2X7R，CTGF 水平与PANSS 各项评分均呈正相关（r=0.464 ～ 0.580，均P<0.05），与MCCB 各项评分均呈负相关（r=-0.603 ～ -0.439，均P<0.05）。结论　精神分裂症患者血清P2X7R 和CTGF 水平升高，与患者临床症状和认知功能密切相关。
Abstract:
Objective　To investigate the correlation between the expression of purinergic ligand-gated ion channel 7 receptor (P2X7R) and connective tissue growth factor (CTGF) in serum and cognitive function and clinical symptoms in patients with schizophrenia. Methods　A total of 160 patients with schizophrenia who were diagnosed and treated in Department of Mental Intensive Care of Wuhan Wudong Hospital from January 2021 to January 2023 were collected as the observation group, and 160 healthy volunteers who underwent physical examinations were collected as the control group for the study. According to the Positive and Negative Symptom Scale (PANSS), patients were evaluated for their clinical and psychiatric symptoms (positive and negative symptoms, general pathological symptoms, and additional symptoms). The patients were grouped into a high score group (PANSS total score≥ 70 points, n=72) and a low score group (PANSS total score < 70 points, n=88). MATRICS consensus cognitive battery (MCCB) was applied to evaluate the cognitive abilities of patients; enzyme-linked immunosorbent assay (ELISA) was applied to detect serum P2X7R and CTGF levels. Spearman method was applied to analyze the correlation between serum P2X7R, CTGF levels and PANSS scores, and MCCB scores in patients with schizophrenia. Results　Compared with the control group, the serum levels of P2X7R (610.71±107.83ng/L vs 384.78±80.62 ng/L) and CTGF (1.85±0.36μg/L vs 1.40±0.21μg/L) in the observation group were increased, with differences of statistical significance (t=21.226, 13.658, all P<0.05). The scores of variety items of MCBB of patients with schizophrenia in the observation group were lower than those in the control group ，with differences of statistical significance (t=14.845 ～ 24.862, all P<0.05)，the positive symptom score (21.10±3.42score), negative symptom score (23.37±5.03 score), general pathological symptom score (39.48±8.11score), additional symptom score (8.26±1.22 score), and PANSS total score (92.21±12.50score) of schizophrenia patients in the high group were higher than those in the low group (13.65±3.04, 15.62±3.91 score, 30.14±6.15 score, 5.20±0.94score, 64.61±5.30score)， with differences of statistical significance (t=14.576, 10.964, 8.280, 17.915, 18.764, all P<0.05). The serum levels of P2X7R and CTGF in patients with schizophrenia in the high group were higher than those in the low group，with differences of statistical significance (t=12.233, 5.923, all P<0.05). The levels of serum P2X7R and CTGF in patients with schizophrenia were positively correlated with PANSS score (r=0.464 ～ 0.580, all P<0.05), and negatively correlated with MCCB score [r=-0.603 ～ -0.439, all P<0.05]. Conclusion　The serum levels of P2X7R and CTGF in patients with schizophrenia are elevated, they are closely related to the clinical symptoms and cognitive function of patients.

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备注/Memo

备注/Memo:
基金项目： 国家自然科学基金项目（81300196）：α1A 肾上腺素能受体短肽降压疫苗研究；湖北省科技厅基金项目（2020CFB765）：Alpha1B- 肾上腺素能受体拮抗性短肽表位筛选。
作者简介：桂秀（1983-）女，本科，主治医师，研究方向：精神及其相关方面，E-mail：g6jwo6@163.com。
通讯作者：乔娟（1979-）女，本科，主治医师，研究方向：老年精神障碍患者的认知问题，E-mail：qrmnou@163.com。
更新日期/Last Update: 2024-01-15