[1]张鹏飞,杨小飞,许怀利,等.慢性萎缩性胃炎患者血清ADAM17和CXCL16表达水平与临床价值研究[J].现代检验医学杂志,2024,39(01):73-77.[doi:10.3969/j.issn.1671-7414.2024.01.013]
　ZHANG Pengfei,YANG Xiaofei,XU Huaili,et al.Study on the Expression and Clinical Value of Serum ADAM17 and CXCL16 Levels in Patients with Chronic Atrophic Gastritis[J].Journal of Modern Laboratory Medicine,2024,39(01):73-77.[doi:10.3969/j.issn.1671-7414.2024.01.013]
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慢性萎缩性胃炎患者血清ADAM17和CXCL16表达水平与临床价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年01期
页码:
73-77
栏目:
论著
出版日期:
2024-01-15

文章信息/Info

Title:
Study on the Expression and Clinical Value of Serum ADAM17 and CXCL16 Levels in Patients with Chronic Atrophic Gastritis
文章编号:
1671-7414（2024）01-073-05
作者:
张鹏飞; 杨小飞; 许怀利; 张 萌
（陕西中医药大学附属西电集团医院消化内科，西安 710077）
Author(s):
ZHANG Pengfei; YANG Xiaofei; XU Huaili; ZHANG Meng
（Department of Gastroenterology, Xidian Group Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine, Xi’an 710077, China）
关键词:
慢性萎缩性胃炎; 解整合素样金属蛋白酶17; C-X-C 趋化因子配体16
分类号:
R573.32；R392.11
DOI:
10.3969/j.issn.1671-7414.2024.01.013
文献标志码:
A
摘要:
目的　研究慢性萎缩性胃炎（chronic atrophic gastritis，CAG）患者血清解整合素金属蛋白酶17(adisintegrinand metalloproteinase-17，ADAM-17) 和C-X-C 趋化因子配体16（C-X-C chemokine ligand 16，CXCL16）水平及临床价值。方法　选取2018 年1 月～ 2020 年1 月陕西中医药大学附属西电集团医院因腹部不适等症状收治的174 例患者，根据病理活检结果分为CAG 组（n=94）和非CAG 组（n=80）。CAG 组根据严重程度分为轻度组（n=27）、中度组（n=30）和重度组（n=37）。以50 例健康体检者为对照组。采用酶联免疫吸附试验（ELISA）检测血清ADAM17 和CXCL16 水平。多因素Logistic 回归分析CAG发生的影响因素，受试者工作特征曲线分析血清ADAM17和CXCL16 对CAG的诊断价值。结果　CAG组血清ADAM17（79.25 ± 9.34ng/L），CXCL16（4.66 ± 0.58μg/L）水平高于非CAG组（73.94 ± 8.26ng/L，4.03± 0.55μg/L）和对照组（53.04 ± 7.20ng/L，1.02 ± 0.35μg/L），差异具有统计学意义（t=5.794，24.854；11.053，55.497，均P<0.05）。重度组CAG 患者血清ADAM17（87.17 ± 9.30ng/L），CXCL16（5.14 ± 0.51μg/L）水平高于轻度组（79.12 ± 9.52ng/L，4.65 ± 0.57μg/L）和中度组（68.54 ± 7.89ng/L，4.02 ± 0.63μg/L），差异具有统计学意义（t=11.574，5.152；11.065，4.987，均P<0.05）。血清ADAM17（OR=1.851，95%CI：1.350 ～ 2.522），CXCL16（OR=1.682，95%CI：1.233 ～ 2.296）是影响CAG 发生的独立危险因素。血清ADAM17，CXCL16 联合诊断CAG 的曲线下面积为0.912（95%CI:0.858 ～ 0.949），大于单一指标0.843（95%CI:0.801 ～ 0.907），0.785（95%CI:0.722 ～ 0.834），差异具有统计学意义（Z=9.357，12.894，均P<0.05）。结论　CAG 患者血清ADAM17，CXCL16 升高，两者与CAG 疾病程度有关，联合检测对CAG 有较高的预测价值。
Abstract:
Objective　To study the serum levels of adisintegrin and metalloproteases 17 (ADAM17) and C-X-C chemokine ligand 16 (CXCL16) in patients with chronic atrophic gastritis (CAG) and their clinical value. Methods　A total of 174 patients admitted to Xidian Group Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine from January 2018 to January 2020 due to abdominal discomfort and other symptoms were selected. Based on pathological biopsy results, they were divided into CAG group (n=94) and non CAG group(n=80). The CAG group was divided into mild group (n=27 ), moderate group (n=30), and severe group (n=37) based on the severity. Meanwhile, 50 healthy examinees were used as the control group. Enzyme-linked immunosorbent assay was used to detect serum ADAM17 and CXCL16 levels. Multivariate logistic regression analysis was used to investigate the influencing factors of CAG occurrence, and the diagnostic values of serum ADAM17 and CXCL16 for CAG were analyzed using receiver operating characteristic curves. Results　The serum levels of ADAM17 (79.25 ± 9.34ng/L) and CXCL16 (4.66 ± 0.58μg/L) in CAG group were higher than those in non-CAG group（73.94 ± 8.26ng/L， 4.03 ± 0.55μg/L） and control group（53.04 ± 7.20ng/L，1.02 ± 0.35μg/L）, and the differences were statistically significant （t=5.794，24.854；11.053，55.497，all P<0.05). The serum levels of ADAM17 (87.17 ± 9.30ng/L) and CXCL16 (5.14 ± 0.51μg/L) in severe CAG patients were higher than those in mild CAG group (79.12 ± 9.52ng/L, 4.65 ± 0.57μg/L) and moderate groups (68.54 ± 7.89ng/L, 4.02 ± 0.63μg/L) , and the differences were statistically significant (t=11.574, 5.152； 11.065，4.987，all P<0.05). Serum ADAM17 (OR=1.851, 95%CI: 1.350 ～ 2.522) and CXCL16 (OR=1.682, 95%CI: 1.233 ～ 2.296) were independent risk factors for CAG. The area under the curve of serum ADAM17 and CXCL16 combined diagnosis of CAG was 0.912 (95%CI: 0.858 ～ 0.949), which was larger than the single indicator of 0.843 (95%CI: 0.801 ～ 0.907) and 0.785 (95%CI: 0.722 ～ 0.834), and the differences were statistically significant (Z= 9.357, 12.894, all P<0.05). Conclusion　The serum levels of ADAM17 and CXCL16 were increased in CAG patients, indicating they may be related to the severity of CAG. The combined detection of ADAM17 and CXCL16 has a high predictive value for CAG.

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相似文献/References:

[1]肖蓉蓉,孙建斌.粪便Hp抗原检测对慢性萎缩性胃炎辅助诊断及病情评估的价值[J].现代检验医学杂志,2019,34(05):64.[doi:10.3969/j.issn.1671-7414.2019.05.016]
　XIAO Rong-rong,SUN Jian-bin.Value of Fecal Hp Antigen Detection in Diagnosis and Assessment of Chronic Atrophic Gastritis[J].Journal of Modern Laboratory Medicine,2019,34(01):64.[doi:10.3969/j.issn.1671-7414.2019.05.016]
[2]史秋霞,李 瑞,邸亚星.慢性萎缩性胃炎患者血清LTB4 和CX3CL1 表达水平及其诊断价值研究[J].现代检验医学杂志,2023,38(03):149.[doi:10.3969/j.issn.1671-7414.2023.03.027]
　SHI Qiu-xia,LI Rui,DI Ya-xing.Serum LTB4 and CX3CL1 Expression Levels and Their Diagnostic Value in Patients with Chronic Atrophic Gastritis[J].Journal of Modern Laboratory Medicine,2023,38(01):149.[doi:10.3969/j.issn.1671-7414.2023.03.027]

备注/Memo

备注/Memo:
基金项目：陕西省科技厅项目（2021SF-318）：内镜检查联合血清指标检测对慢性萎缩性胃炎的价值。
作者简介：张鹏飞（1989-），女，硕士研究生，主治医师，研究方向：消化肝病，E-mail：zhangpengfei202303@126.com。
通讯作者：张萌（1989-），女，硕士研究生，主治医师，研究方向：消化肝病，E-mail：449072206@qq.com。
更新日期/Last Update: 2024-01-15