[1]王 君,黄长明,吴 瑕,等.慢性阻塞性肺疾病患者血清内皮发育调节基因-1表达水平与炎症反应及疾病严重程度的相关性研究[J].现代检验医学杂志,2025,40(02):160.[doi:10.3969/j.issn.1671-7414.2025.02.030]
　WANG Jun,HUANG Changming,WU Xia,et al.Study on the Correlation between the Expression Level of Serum Developmental Endothelial Locus-1 and Inflammatory Response and Disease Severity in Patients with Chronic Obstructive Pulmonary Disease[J].Journal of Modern Laboratory Medicine,2025,40(02):160.[doi:10.3969/j.issn.1671-7414.2025.02.030]
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慢性阻塞性肺疾病患者血清内皮发育调节基因-1表达水平与炎症反应及疾病严重程度的相关性研究()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年02期
页码:
160
栏目:
论著
出版日期:
2025-03-15

文章信息/Info

Title:
Study on the Correlation between the Expression Level of Serum Developmental Endothelial Locus-1 and Inflammatory Response and Disease Severity in Patients with Chronic Obstructive Pulmonary Disease
文章编号:
1671-7414（2025）02-160-05
作者:
王 君，黄长明，吴 瑕，张 冉
（淮安市第五人民医院呼吸与危重症医学科，江苏淮安 223300）
Author(s):
WANG Jun，HUANG Changming，WU Xia，ZHANG Ran
（Respiratory and Critical Care Medicine，Huai’an Fifth People’s Hospital，Jiangsu Huai’an 223300，China）
关键词:
慢性阻塞性肺疾病; 内皮发育调节基因-1; 炎症反应
分类号:
R563；R392.11
DOI:
10.3969/j.issn.1671-7414.2025.02.030
文献标志码:
A
摘要:
目的 探讨内皮发育调节基因-1（Del-1）与慢性阻塞性肺疾病（COPD）患者炎症反应以及疾病严重程度的关系。方法 选取淮安市第五人民医院在2023 年1 ～ 7 月收治的82 例COPD 患者作为COPD 组，并将其中40 例处于急性加重的患者纳入到急性加重组，将42 例处于稳定期的患者纳入到稳定组；另选取同期体检的健康志愿者40 例作为对照组。检测所有研究对象血清Del-1，C 反应蛋白（CRP）、白细胞介素-1β（IL-1β）以及中性粒细胞与淋巴细胞比值（NLR）的水平。采用Pearson 法分析血清Del-1 与炎症指标的相关性；采用受试者工作特征（ROC）曲线分析血清Del-1 对COPD 患者急性加重的预测价值。结果 COPD 组的血清CRP，IL-1β 以及NLR 水平均高于对照组（t=12.047，13.107，9.404），COPD 组血清Del-1 水平为386.87±42.34pg/ml，低于对照组的512.63±60.21pg/ml（t=13.343），差异具有统计学意义（均P<0.05）；急性加重组的血清CRP，IL-1β 及NLR 水平均高于稳定组（t=4.170，5.292，5.919），急性加重组的血清Del-1 水平为347.64±40.69 pg/ml，低于稳定组（424.23±48.31 pg/ml）（t=7.746），差异具有统计学意义（均P<0.05）。经Pearson 分析显示，COPD 患者的血清Del-1 水平与血清CRP，IL-1β，NLR 水平均呈负相关（r=-0.534，-0.587，-0.612，均P<0.05）；经ROC 分析显示，血清Del-1 对COPD 患者急性加重的预测价值较高，曲线下面积（95%CI）为0.886（0.812 ～ 0.960），取最佳截断值380.65 pg/ml 时，敏感度和特异度分别为82.50%，85.00%。结论 血清Del-1 在COPD 患者中呈现低表达，与患者的炎症反应及疾病严重程度呈负相关，有望成为预测COPD 急性加重风险的新型生物标志物。
Abstract:
Objective To explore the relationship between developmental endothelial locus-1 (Del-1) and inflammatory response and disease severity in patients with chronic obstructive pulmonary disease (COPD). Method 82 COPD patients admitted to Huai’an Fifth People’s Hospital from January 2023 to July 2023 were selected as the COPD group. Among them, 40 patients with acute exacerbation were included in the acute exacerbation group, and 42 patients in the stable phase were included in the stable group. Another 40 healthy volunteers who underwent physical examinations during the same period were selected as the control group. The levels of serum Del-1, C-reactive protein (CRP),interleukin-1β (IL-1β) and neutrophil to lymphocyte ratio (NLR) in all study subjects were detected. Pearson’s method was used to analyze the correlation between serum Del-1 and inflammatory markers. The predictive value of serum Del-1 for acute exacerbation in COPD patients was analyzed using receiver operating characteristic (ROC) curves. Result The serum CRP, IL-1β and NLR levels in the COPD group were higher than those in the control group (t=12.047，13.107，9.404), the serum Del-1 level in the COPD group was 386.87±42.34 pg/ml, lower than that in the control group 512.63±60.21 pg/ml (t=13.343)，and the differences were statistically significant (all P<0.05). The serum CRP, IL-1β and NLR levels in the acute exacerbation group were higher than those in the stable group (t=4.170，5.292，5.919), the serum Del-1 level in the acute exacerbation group was 347.64±40.69 pg/ml, lower than that in the stable group 424.23±48.31 pg/ml (t=7.746)，and the differences were statistically significant (all P<0.05). Pearson analysis showed that the serum Del-1 level in COPD patients were negatively correlated with serum CRP, IL-1β and NLR levels (r=-0.534，-0.587，-0.612，all P <0.05). ROC analysis showed that serum Del-1 had a high predictive value for acute exacerbation in COPD patients, with an AUC(95% CI) of 0.886 (0.812 ～ 0.960). When the optimal cutoff value was 380.65 pg/ml, the sensitivity and specificity were 82.50% and 85.00%, respectively. Conclusion Serum Del-1 is low expression in COPD patients and is ngeatively correlated with their inflammatory response and disease severity, it is expected to become a new biomarker for predicting the risk of acute exacerbation of COPD.

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备注/Memo

备注/Memo:
基金项目：江苏省卫生健康委科研项目（ZD2021023）。
作者简介：王君（1989-），女，本科，主治医师，研究方向：呼吸与危重症，E-mail：wangjun562314@126.com。
通讯作者：张冉（1990-），男，本科，主治医师，研究方向：呼吸与危重症医学科慢性阻塞性肺疾病，E-mail：1029900751@qq.com。
更新日期/Last Update: 2025-03-15