[1]胡小燕,郑 晓,嵇华夏,等.血清 PCT 与 BNP 水平联合检测对慢性阻塞性肺疾病急性加重期并发心力衰竭的临床诊断价值[J].现代检验医学杂志,2021,36(03):128-131.[doi:10.3969/j.issn.1671-7414.2021.03.029]
 HU Xiao-yan,ZHENG Xiao,JI Hua-xia,et al.Clinical Diagnostic Value of Combined Detection of Serum PCT and BNPLevels in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Heart Failure[J].Journal of Modern Laboratory Medicine,2021,36(03):128-131.[doi:10.3969/j.issn.1671-7414.2021.03.029]
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血清 PCT 与 BNP 水平联合检测对慢性阻塞性肺疾病急性加重期并发心力衰竭的临床诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
128-131
栏目:
检验与临床
出版日期:
2021-05-31

文章信息/Info

Title:
Clinical Diagnostic Value of Combined Detection of Serum PCT and BNPLevels in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Heart Failure
文章编号:
1671-7414(2021)03-128-05
作者:
胡小燕郑 晓嵇华夏
(上海市金山区亭林医院呼吸内科 , 上海 201505)
Author(s):
HU Xiao-yan ZHENG Xiao JI Hua-xia QIAN Bao WU Yan-hong ZHENG Yong-hua
(Department of Respiratory Medicine, Tinglin Hospital of Jinshan District, Shanghai 201505,China)
关键词:
降钙素原B 型脑利钠肽慢性阻塞性肺疾病心力衰竭
分类号:
R563;R446.11
DOI:
10.3969/j.issn.1671-7414.2021.03.029
文献标志码:
A
摘要:
目的 探讨血清降钙素原(PCT)、B 型脑利钠肽(BNP)以及二指标联合检测对慢性阻塞性肺疾病急性加重期(AECOPD)并发心力衰竭(HF)的临床诊断价值。方法 选取 2018 年 6 月 ~2019 年 12 月期间就诊于上海市金山区亭林医院呼吸内科且确诊为 AECOPD 的患者 199 例,根据是否并发 HF 症状分为 AECOPD 并发 HF 组(87 例)和单 AECOPD 组(112 例)。并对比分析 PCT 与 NBP 指标以及二者联合检测 AECOPD 并发 HF 患者的诊断价值。结果 AECOPD 并发 HF 组患者的 PCT 和 NBP 指标相比单 AECOPD 组患者明显增高,差异有统计学意义(Z=-3.283 和-4.518, 均 P <0.05)。ROC 曲线分析表明,联合检测的 AUC 值(0.908)高于 PCT (0.710) 和 NBP(0.843) 单独检测,差异有统计学意义(Z=4.183 和 2.358,P<0.05)。联合检测诊断灵敏度与特异度最佳,分别为 86.2% 与 84.8%。联合检测的诊断准确度(85.0%)高于 PCT (69.0%) 和 BNP (78.3%) 单独检测,差异有统计学意义(χ2=3.112 和 2.587, 均 P<0.05)。结论 AECOPD 并发 HF 组患者的血清 PCT 和 BNP 指标明显增高,二者联合检测相比血清 PCT 和 NBP 单独检测具有更高的诊断效能与临床价值。

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备注/Memo

备注/Memo:
基金项目:上海市卫生健康委员会科研课题计划,项目批号:201940280。
作者简介:胡小燕(1982-),女,本科,主治医师,研究方向 : 呼吸内科,E-mail:83996798@qq.com。
通讯作者:郑永华,E-mail:zhengyonghua0118@hotmail.com。
更新日期/Last Update: 1900-01-01