[1]文 艳,刘爱胜,张 勇,等.ICU危重病患者深部真菌感染血清中降钙素原和（1,3)-β-D葡聚糖联合检测的临床意义[J].现代检验医学杂志,2015,30(02):120-122.[doi:10.3969/j.issn.1671-7414.2015.02.037]
　WEN Yan,LIU Ai-sheng,ZHANG Yong,et al.Diagnosis Value of Joint Detection of Critical Patients Procalcitonin and(1,3)-beta-D Glucan with Deep Fungus Infection in ICU[J].Journal of Modern Laboratory Medicine,2015,30(02):120-122.[doi:10.3969/j.issn.1671-7414.2015.02.037]
点击复制

ICU危重病患者深部真菌感染血清中降钙素原和（1,3)-β-D葡聚糖联合检测的临床意义()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
120-122
栏目:
检验与临床
出版日期:
2015-03-20

文章信息/Info

Title:
Diagnosis Value of Joint Detection of Critical Patients Procalcitonin and(1,3)-beta-D Glucan with Deep Fungus Infection in ICU
作者:
文 艳1; 刘爱胜2; 张 勇3; 李 伟3
1.深圳市光明新区人民医院ICU,广东深圳 518106; 2.深圳市龙华新区人民医院检验科,广东深圳 518109; 3.深圳市龙华新区中心医院检验科,广东深圳 518110
Author(s):
WEN Yan1; LIU Ai-sheng2; ZHANG Yong3; LI Wei3
1.ICU,Shenzhen Guangming New District People's Hospital,Guangdong Shenzhen518106,China; 2.Department of Clinical Laboratory,Shenzhen Longhua New District People's Hospital,Guangdong Shenzhen 518109,China; 3.Department of Clinical Laboratory,Shenzhen Longhua New District Center Hospital,Guangdong Shenzhen 518110,China
关键词:
降钙素原; (1; 3)-β-D葡聚糖;  重症监护室;  深部真菌感染;  价值
分类号:
R379; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.02.037
文献标志码:
A
摘要:
目的 探讨降钙素原(PCT)和(1,3)-β-D葡聚糖(G试验)联合检测在ICU危重病患者深部真菌感染诊断中的临床应用价值。方法 对2012年11月～2014年8月确诊为深部真菌感染的ICU危重病患者106例进行血清PCT和(1,3)-β-D葡聚糖含量检测,并与ICU非深部真菌感染的危重患者519例进行对比分析,以配对t检验来比较结果之间的差异性。结果 106例深部真菌感染的ICU危重病患者血清中PCT为0.701±0.22 pg/ml及(1,3)-β-D葡聚糖为37.82±18.43pg/ml,明显高于519例ICU非深部真菌感染的危重患者血清中的PCT(0.238±0.12 pg/ml)及(1,3)-β-D葡聚糖(14.96±4.37 pg/ml),两者结果比较差异有统计学意义(t=7.426,8.179,P均<0.05); 106例深部真菌感染的ICU危重病患者血清中PCT阳性检出率为57.5%(61/106),明显低于(1,3)-β-D葡聚糖阳性检出率89.6%(95/106),差异有统计学意义(χ2=13.645,P<0.05)。结论 ICU深部真菌感染危重病患者血清中的PCT和(1,3)-β-D葡聚糖含量明显高于ICU非深部真菌感染的危重患者,PCT和(1,3)-β-D葡聚糖联合检测对ICU危重病患者深部真菌感染诊断有重要的临床意义。
Abstract:
Objective To explore the clinical application of jiont detection of critical patients procalcitomin(PCT)and(1,3)-beta D-glucan with deep fungus infection in ICU.Methods From November 2012 to August 2014 diagnosed with deep fungal infection of ICU critical patients,106 cases of patients with serum PCT and(1,3)-beta-D glucan contentdetection,and ICU of deep fungal infection in critically ill patients,519 cases were analyzed,with differencesbetween the paired t test to compare the results.Results 106 patients with deep fungal infection of ICU critical patients serum PCT for 0.701±0.22 pg/ml and(1,3)-beta-D glucan for 37.82±18.43 pg/ml,significantly higher than the 519 cases of ICU ofdeep fungal infection in critically ill patients in the serum PCT for 0.238±0.12 pg/ml and(1,3)-beta-D glucan for 14.96±4.37 pg/ml,comparing differences between both results was statistically significant(t=7.426,8.179,P<0.05).106 patients with deep fungal infection of ICU critical patients serumPCT positive detection rate was 57.5%(61/106),significantly lower than the(1,3)-beta-D glucan positive detection rate 89.6%(95/106),difference was statistically significant(χ2=13.645,P<0.05).Conclusion Deep fungal infection in critical care patients in the ICU in the serum PCT and(1,3)-beta-D glucan content of deep fungus infection in critically illpatients was significantly higher than the ICU,PCT and(1,3)-beta-D glucanjoint detection of deep fungal infection in patients with ICU critical patientsdiagnosis has important clinical significance.

参考文献/References:

[1] Martin GS,Mannino DM,Eaton S,et al.The epide-miology of sepsis in the united states from 1979 through 2000[J].N Engl J Med,2003,348(16):1546-1554.
[2] 陈凌玉,沈跃飞.ICU患者深部真菌感染的高危因素分析[J].浙江实用医学,2006,11(5):359-360. Chen LY,Shen YF.Risk factors analysis of deep fungal infection inICU patients[J].Zhejiang Practical Medicine,2006,11(5):359-360.
[3] 张圣岸,王盛标,黄 强,等.ICU深部真菌感染的现状和对策[J].中国医药导报,2008,5(3):98-100. Zhang SA,Wang SB,Huang Q,et al.The current situation issues andcountermeasures of deep fungal infection in ICU[J].China Medical Herald,2008,5(3):98-100.
[4] Ostrosky-Zeichner L,Alexander BD,Kett DH,et al.Multicenter clinicalevaluation of the(1,3)beta-D-glucan assay as an aid to diagnosis of fungal infections in humans[J].Clin Infect Dis,2005,41(5):654-659.
[5] 张晓艳,董 方,赵顺英,等.血浆(1-3)-β-D葡聚糖检测对儿童侵袭性真菌感染诊断价值[J].中国循证儿科杂志,2012,7(3):192-195. Zhang XY,Dong F,Zhao SY,et al.The diagnostic value of plasma-1,3-β-D glucan to invasive fungal infection in children[J].Chinese Journalof Evidence-Based Pediatric,2012,7(3):192-195.
[6] White PL,Linton CJ,Perry MD,et al.The evolution and evaluation of a whole blood polymerase chain reaction assay for the diection of invasive aspergillosis in hematology patients in a routine clinical setting[J].Clin Infect Dis,2006,42(4):479-486.
[7] Miyazaki T,Kohno S,Mitsutake K,et al.Plasma(1-3)-beta-D-glucan and fungal antigenemia in patients with candidemia,aspergillosis and cryptococcosis[J].J Clin Microbiol,1995,33(12):3115-3118.
[8] 陈 峰,陶晓勤,刁文晶,等.国产血浆(1-3)-β-D葡聚糖检测试剂对侵袭性真菌病诊断价值评估[J].上海交通大学(医学版),2012,32(3):348-351. Chen F,Tao XQ,Diao WJ,et al.Evaluation of domestic plasma(1-3)β-D-glucan detection reagent in diagnosis of invasive fungal disease[J].Journal of Shanghai Jiaotong University(Medical Sciences),2012,32(3):348-351.
[9] 杨洁琼.深部真菌感染患者血浆(1-3)-β-D葡聚糖检测的临床价值[J].现代检验医学杂志,2009,24(2):12-13. Yang JQ.Deep fungal infection in patients with plasma(1-3)-the clinical value of beta glucan D detection[J].J Mod Lab Med,2009,24(2):12-13.
[10] Bedirli A,Kerem M,Pasaoglu H,et al.Beta-glucan attenuates inflammatory cytokine release and prevents acute lung injury in an experimental model of sepsis[J].Shock,2007,27(4):397-401.

相似文献/References:

[1]周玉宝a,陈芦斌b,刘芳a,等.腹腔镜与ERCP手术后血清CRP和PCT检测比较分析[J].现代检验医学杂志,2015,30(05):4.[doi:10.3969/j.issn.1671-7414.2015.05.002]
　ZHOU Yu-baoa,CHEN Lu-binb,LIU Fanga,et al.Comparative Analysis of Serum CRP and PCT Detection after ERCP and Laparoscopic Operation[J].Journal of Modern Laboratory Medicine,2015,30(02):4.[doi:10.3969/j.issn.1671-7414.2015.05.002]
[2]刘运双.血清降钙素原水平预示革兰阴性菌血症的价值评估[J].现代检验医学杂志,2015,30(02):77.[doi:10.3969/j.issn.1671-7414.2015.02.024]
　LIU Yun-shuang.Values of Procalcitonin Level in Serum for Predicting Gram-negative Bacteremia[J].Journal of Modern Laboratory Medicine,2015,30(02):77.[doi:10.3969/j.issn.1671-7414.2015.02.024]
[3]马志超,黄白丽,阮和球,等.降钙素原联合呼吸道病原体抗体检测在小儿肺炎的诊断价值[J].现代检验医学杂志,2015,30(02):144.[doi:10.3969/j.issn.1671-7414.2015.02.046]
　MA Zhi-chao,HUANG Bai-li,RUAN He-qiu,et al.Diagnosis Value of PCT Combined with Respiratory Pathogen Detection in Pneumonia in Children[J].Journal of Modern Laboratory Medicine,2015,30(02):144.[doi:10.3969/j.issn.1671-7414.2015.02.046]
[4]尹良琼,余艾霞.降钙素原、胱抑素C联合检测对脓毒症患儿28天死亡率的预测价值研究[J].现代检验医学杂志,2017,32(02):153.[doi:10.3969/j.issn.1671-7414.2017.02.043]
　YIN Liang-qiong,Y Ai-xia.Predictive Value of the Combined Detection of Procalcitonin and Cystatin C in Children with Sepsis 28 Days Mortality[J].Journal of Modern Laboratory Medicine,2017,32(02):153.[doi:10.3969/j.issn.1671-7414.2017.02.043]
[5]严海忠,王伟佳,慕月晶,等.血液及尿液中降钙素原(PCT检测在泌尿系统感染定位中的诊断价值[J].现代检验医学杂志,2017,32(04):116.[doi:10.3969/j.issn.1671-7414.2017.04.033]
　YAN Hai-zhong,WANG Wei-jia,MU Yue-jing,et al.Diagnostic Value of Detecting the Serum and Urine Procalcitonin(PCT)for the Urinary System Infection[J].Journal of Modern Laboratory Medicine,2017,32(02):116.[doi:10.3969/j.issn.1671-7414.2017.04.033]
[6]王臣玉,杨丽萍,陈 磊,等.两种降钙素原检测系统比较实验研究[J].现代检验医学杂志,2017,32(04):143.[doi:10.3969/j.issn.1671-7414.2017.04.041]
　WANG Chen-yu,YANG Li-ping,CHEN Lei,et al.Methodology Comparison Study on Two Analysis Systems of Procalcitonin[J].Journal of Modern Laboratory Medicine,2017,32(02):143.[doi:10.3969/j.issn.1671-7414.2017.04.041]
[7]李军民,白 晓,孟 茜,等.COPD患者血清降钙素原水平与肺功能的关系研究[J].现代检验医学杂志,2018,33(01):148.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　LI Jun-min,BAI Xiao,MENG Xi,et al.Relationship Study on Serum Levels of Procalcitonin and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease[J].Journal of Modern Laboratory Medicine,2018,33(02):148.[doi:10.3969/j.issn.1671-7414.2018.01.001]
[8]王亚南.标本溶血对固相免疫层析法检测降钙素原结果影响的实验研究[J].现代检验医学杂志,2018,33(04):127.[doi:10.3969/j.issn.1671-7414.2018.04.035]
　WANG Ya-nan.Experimental Study on the Effect of Sample Hemolysis on the Detection of Procalcitonin by Solid Phase Immunochromatography Assay[J].Journal of Modern Laboratory Medicine,2018,33(02):127.[doi:10.3969/j.issn.1671-7414.2018.04.035]
[9]刘佳丽,王 薇,何法霖,等.全国566家临床实验室血清降钙素原室内质量控制不精密度调查与分析[J].现代检验医学杂志,2018,33(02):139.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　LIU Jia-li,WANG Wei,HE Fa-lin,et al.Investigation and Analysis of the Coefficient of Variation of Internal Quality Control of the Serum Procalcitonin in 566 Laboratories in China[J].Journal of Modern Laboratory Medicine,2018,33(02):139.[doi:10.3969/j.issn.1671-7414.2018.02.001]
[10]戴晓勇,陈永珍,华玮,等.血清淀粉样蛋白A,C反应蛋白和降钙素原在脓毒性休克中的应用价值与相关性分析[J].现代检验医学杂志,2019,34(01):47.[doi:10.3969/j.issn.1671-7414.2019.01.012]
　DAI Xiao-yong,CHEN Yong-zhen,HUA Wei,et al.Application and Correlation Analysis of Serum Amylase A， C-reactive Protein and Procalcitonin in Septic Shock[J].Journal of Modern Laboratory Medicine,2019,34(02):47.[doi:10.3969/j.issn.1671-7414.2019.01.012]

备注/Memo

备注/Memo:
基金项目:深圳市龙华新区科技创新资金项目,项目编号:20140917A1030045. 作者简介:文 艳(1979-),女,本科,学士,主管护师,主要从事ICU护理工作,E-mail:curious1997@163.com。
更新日期/Last Update: 2015-03-20