[1]刘运双.血清降钙素原水平预示革兰阴性菌血症的价值评估[J].现代检验医学杂志,2015,30(02):77-79,83.[doi:10.3969/j.issn.1671-7414.2015.02.024]
　LIU Yun-shuang.Values of Procalcitonin Level in Serum for Predicting Gram-negative Bacteremia[J].Journal of Modern Laboratory Medicine,2015,30(02):77-79,83.[doi:10.3969/j.issn.1671-7414.2015.02.024]
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血清降钙素原水平预示革兰阴性菌血症的价值评估()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
77-79,83
栏目:
论著
出版日期:
2015-03-20

文章信息/Info

Title:
Values of Procalcitonin Level in Serum for Predicting Gram-negative Bacteremia
作者:
刘运双
绵阳市中心医院检验科,四川绵阳 621000
Author(s):
LIU Yun-shuang
Department of Clinical Laboratory, Mianyang Central Hospital,Sichuan Miangyang 621000,China
关键词:
降钙素原;  革兰阴性菌;  菌血症
分类号:
R515.3; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.02.024
文献标志码:
A
摘要:
目的 评估血清降钙素原(PCT)水平预示革兰阴性(GN)菌血症的价值。方法 选取2013年1月～12月同时进行了血液培养和PCT测定的病例,排除污染生长情况,纳入研究的血液培养阳性499例,依据培养鉴定结果将血液培养阳性病例分组:GN菌血症组314例,其中,男性159例,女性155例; 革兰阳性(GP)菌血症组185例,男性107例,女性78例。对研究对象的血清PCT结果进行统计学处理。结果 GN菌血症组PCT水平(中位数=5.16,0.02～450.10 ng/ml)明显高于GP菌血症组(中位数=0.38,0.02～44.70 ng/ml)(P=0.000); 随着PCT水平的升高,GN菌血症所占比例越来越高,当PCT≥45.0 ng/ml,GN菌血症的比例占到100%; 以6.00 ng/ml为判断值,PCT诊断GN菌血症的灵敏度、特异度、阳性预示值和阴性预示值分别为49.4%,85.2%,85.6%和50.0%,ROC曲线下面积(AUC)为0.714,95%可信区间(CI)为0.672～0.753,SE=0.0229,P<0.000 1。结论 PCT是预示GN菌血症早期的和可靠的标记物,可以早期地指导抗生素治疗的药物选择。
Abstract:
Objective To evaluate the values of procalcitonin(PCT)level in serum for predicting Gram-negative bacteremia(GNB).Methods Among 499 candidates for study entry,314 were GN bacteraemia,and 185 were Gram-positive bacteraemia(GPB).The serum PCT level were measured in 499 candidates.Results PCT levels were foundto be markedly higher in patients with GNB(median=5.16, 0.02～450.10 ng/ml)than in those with GPB(median=0.38, 0.02～44.70ng/ml)(P=0.000).The percentage of GNB were increased along with PCT level.The proportion of GNB was100% when PCT ≥45.0 ng/ml.For prediction of GNB a PCT level of 6.00 ng/ml had a sensitivity of 49.4% and specificity of 85.2% and positive predictive value of 85.6% and negative predictive value of 50.0%,respectively.The area under the receiver operating characteristic curve for discriminating GNB and GPB was0.714,confidence interval of 95% was 0.672～0.753,SE=0.0229,P<0.0001.Conclusion PCT is an early and reliable indicator forpredicting GNB.

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备注/Memo

备注/Memo:
作者简介:刘运双(1964-),男,大学专科,副主任检验师,从事临床化学专业,Tel:13980125739,E-mail:yunshuang1964@sina.cn。
更新日期/Last Update: 2015-03-20