[1]周 珂,苏嘉彧,张 影,等.糖尿病肾病患者血清FGL1表达水平与代谢及肾功能指标的相关性研究[J].现代检验医学杂志,2025,40(04):127-130.[doi:10.3969/j.issn.1671-7414.2025.04.022]
　ZHOU Ke,SU Jiayu,ZHANG Ying,et al.Study on the Correlation between Serum FGL1 Expression Level and Metabolic and Renal Function Indexes in Patients with Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2025,40(04):127-130.[doi:10.3969/j.issn.1671-7414.2025.04.022]
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糖尿病肾病患者血清FGL1表达水平与代谢及肾功能指标的相关性研究()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年04期
页码:
127-130
栏目:
论著
出版日期:
2025-07-15

文章信息/Info

Title:
Study on the Correlation between Serum FGL1 Expression Level and Metabolic and Renal Function Indexes in Patients with Diabetic Nephropathy
文章编号:
1671-7414（2025）04-127-04
作者:
周 珂1a,2，苏嘉彧3，张 影3，朱慧敏2，王 璇3，胡小超3，朱 琳1c，顾万建1b，刘史佳1a,2,3
（1. 南京中医药大学附属医院/ 江苏省中医院a. 药学部；b. 检验科；c. 内分泌科，南京 210029；2. 中国药科大学中药学院，南京211199；3. 南京中医药大学第一临床医学院，南京 210023)
Author(s):
ZHOU Ke1a,2，SU Jiayu3，ZHANG Ying3，ZHU Huimin2，WANG Xuan3，HU Xiaochao3，ZHU Lin1c，GU Wanjian1b，LIU Shijia1a,2,3
(1a. Department of Pharmacy；1b. Department of Inspection；1c. Department of Endocrinology， Affiliated Hospital of Nanjing University of Chinese Medicine /Jiangsu Province Hospital of Chinese Medicine，Nanjing 210029，China；2. School of Traditional Chinese Me
关键词:
糖尿病肾病; 糖尿病; 血清纤维蛋白原样蛋白1; 肾功能指标
分类号:
R587.2；R446.11
DOI:
10.3969/j.issn.1671-7414.2025.04.022
文献标志码:
A
摘要:
目的 探究糖尿病肾病（DN）和糖尿病(DM) 患者血清纤维蛋白原样蛋白1（FGL1）表达水平与代谢及肾功能指标的相关性及预后关系，为临床诊治提供参考。方法 选取2017 年1 月～ 2023 年4 月在江苏省中医院诊治的30 例DM 患者为DM 组，68 例DN 患者为DN 组和36 例健康体检者为对照组，并根据是否含有大量蛋白尿以及严重程度进一步将DN 组分为DN 早期（DN-E）组（n=38）和DN 晚期（DN-A）组（n=30）。收集受试者白蛋白（ALB）、患者肾小球滤过率（eGFR）、尿微量白蛋白/ 肌酐（ACR）等临床资料；酶联免疫吸附（ELISA）法检测血清FGL1 水平；相关性采用Pearson 线性相关；诊断价值分析采用受试者工作特征（ROC）曲线。结果 与对照组相比，DM 组患者的ACR 和FGL1 水平升高，eGFR 水平降低，差异具有统计学意义（t=5.686，4.336，-4.683，均P<0.05）；与DM 组相比，DN-E 组患者ACR，FGL1 水平升高，eGFR 水平降低，差异具有统计学意义（t=5.275，3.454，-4.969，均P<0.05）。与DN-E 组相比，DN-A 组患者的ACR 和FGL1 水平升高，eGFR 水平降低，差异具有统计学意义（t=7.881，7.051，-5.596，均P<0.05）。血清FGL1 水平与ALB 和eGFR 呈负相关（r=-0.638，-0.574，均P ＜ 0.05），与ACR 呈正相关（r=0.691，P ＜ 0.05）。血清FGL1 水平诊断DN 患者的AUC(95%CI)，特异度和敏感度分别为0.947(0.908 ～ 0.987)，100% 和82.4%。结论 DN 和DM 患者血清FGL1 水平呈高水平，且其血清FGL1 水平与ALB，eGFR，ACR 等常见的诊断DN 的代谢指标紧密相关，可能具有一定的临床诊断价值。
Abstract:
Objective To explore the correlation between the expression level of serum fibrinogen-like protein 1 (FGL1) and the indexes of metabolism and renal function in patients with diabetic nephropathy(DN) and diabetes mellitus（DM）, and provide reference for clinical diagnosis and treatment. Methods From January 2017 to April 2023，30 patients with DM and treated in Jiangsu Province Hospital of Chinese Medicine were selected as the DM group, 68 patients with DN were selected as the DN group, and 36 healthy subjects were selected as the control group. The DN group was further divided into the early DN(DN-E) group (n=38) and the late DN(DN-A) group (n=30) according to whether there was a large amount of proteinuria and the severity. Clinical data such as serum albumin (ALB), estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR) were collected. Serum FGL1 level was detected by enzyme-linked immunosorbent assay(ELISA). Pearson linear correlation was used for correlation, the diagnostic value was analyzed by ROC curve. Results Compared with the control group, the levels of ACR, FGL1 in patients with DM group increased, the levels of eGFR decreased, and the differences were statistically significant (t=5.686, 4.336, -4.683, all P < 0.05）. Compated with the DM group, the levels of ACR, FGL1 in patients with DN-E group was increased, and the level of eGFR was decreased, and the differences were statistically significant（t=5.275, 3.454, -4.969, all P<0.05）.Compared with the DN-E group, the levels of ACR, FGL1 in the DN-A group were increased, the levels of eGFR were decreased, and the differences were statistically significant (t=7.881, 7.051, -5.596, all P < 0.05). Serum FGL1 level was negatively correlated with ALB and eGFR (r=-0.638, -0.547, all P < 0.05), and positively correlated with ACR (r= 0.691, P< 0.05). The AUC(95%CI)，specificity and sensitivity of serum FGL1 level in the diagnosis of DN were 0.947 (0.908 ～ 0.987), 100 % and 82.4 %, respectively. Conclusion The level of serum FGL1 in DN and DM patients is high, and the level of serum FGL1 is closely related to the common metabolic indexes such as ALB, eGFR and ACR in the diagnosis of DN, which may have certain clinical diagnostic value.

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备注/Memo

备注/Memo:
基金项目： 中国药学会医院药学专委会人才专项资助项目（CPA-Z05-ZC-2023-003）；2023 年江苏省科技计划专项资金(重点研发计划社会发展) （BE2023607）；2022 年度江苏省中医院科主任学术提升专项课题（Y2022ZR13）。
作者简介：周珂（1999-），男，硕士研究生在读，主要从事中药学专业，E-mail:zhouy0222@163.com。
通讯作者：刘史佳（1983-），男，研究员，主要从事中药临床药理研究，E-mail:liushijia2011@ 16
更新日期/Last Update: 2025-07-15