[1]孟 俊a,顾志冬a,陈呢喃b,等.视黄醇结合蛋白4检测在营养性疾病 及肝肾损害检测中的临床应用[J].现代检验医学杂志,2015,30(01):1-3.[doi:10.3969/j.issn.1671-7414.2015.01.001]
　MENG Juna,GU Zhi-donga,CHEN Ninanb,et al.Assessment of Retinol Binding Protein 4 in Nutritional Diseases and Liver or Kidney Diseases[J].Journal of Modern Laboratory Medicine,2015,30(01):1-3.[doi:10.3969/j.issn.1671-7414.2015.01.001]
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视黄醇结合蛋白4检测在营养性疾病 及肝肾损害检测中的临床应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
1-3
栏目:
述评
出版日期:
2015-01-30

文章信息/Info

Title:
Assessment of Retinol Binding Protein 4 in Nutritional Diseases and Liver or Kidney Diseases
文章编号:
1671-7414(2015)01-001-04
作者:
孟 俊a; 顾志冬a; 陈呢喃b; 张冬青b
上海交通大学医学院a.附属瑞金医院检验科;
b.上海市免疫学研究所,上海 200025
Author(s):
MENG Juna; GU Zhi-donga; CHEN Ninanb; ZHANG Dong-qingb
a.Department of Clinical Laboratory,Ruijin Hospital;
b.Shanghai Institute of Immunology, Medical School of Shanghai Jiaotong University,Shanghai 200025,China
关键词:
视黄醇结合蛋白4;  营养性疾病;  肝肾损害
分类号:
R531.3; R381
DOI:
10.3969/j.issn.1671-7414.2015.01.001
文献标志码:
A
摘要:
视黄醇结合蛋白(retinol binding protein,RBP)是一种分泌型视黄醇结合蛋白,主要合成于肝脏,广泛分布于人体血液、尿液等体液中的视黄醇(VitA)运载蛋白,在协助VitA发挥生理功能中起到关键作用
[1]。最新研究表明:RBP4是一种新的脂肪细胞因子,参与胰岛素抵抗和2型糖尿病的发生,与糖尿病肾病、营养性疾病等的发展存在着一定的相关性。这一发现使得RBP4更加受到人们的重视。该文就RBP4的生理功能,在肝肾疾病、糖尿病等各类疾病方面的应用以及新型临床检测方法作一综述。
Abstract:
Retinol binding protein 4(RBP4)was a class ofsecreting protein,mainly synthesized by the liver,widely distributed in the human body blood,urine and other body fluids.It plays an important role in assisting the physiological function of vitamin A
[1].Recent research shows that RBP4 was a new kind of adipocytokine,participated in insulin resistance andoccurrence of type 2 diabetes,and had a closed relationship with diabetic nephropathy,nutritional disease.This article describes the function of RBP4,review the relationship between RBP4 and nutritional or other type of diseases,and new clinical detection method with RBP4.

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备注/Memo

备注/Memo:
基金项目:本课题系国家自然科学基金面上项目(31270963); 上海市科委重点连续资助项目(10JC1408500); 上海市科委生物医药领域科技支撑项目2014年度“科技创新行动计划”项目(14431903700); 上海交通大学医学院附属瑞金医院优青项目(8003)。
作者简介:孟 俊(1982-),男,在读硕士,主管技师,研究方向:免疫学相关检测,E-mail:mjun2004@126.com。
通讯作者:张冬青,E-mail:dqzhang1333@163.com。
更新日期/Last Update: 2015-01-30